Neuromuscular Junction Disorders (Msq Drill 187)

1. What autoimmune disease leads to a loss of functional acetylocholine receptors at the neuromuscular junction due to autoantibodies against the acetycholine receptor?

SLE

Rheumatoid arthritis

Myasthenia gravis

Myositis

2. Can the weakness of MG become generalized?

Yes

No

3. 60% of patients with Lambert-Eaton syndrome have:

Breast cancer

Small cell carcinoma of the lung

Ovarian cancer

Prostate cancer

4. Can Lambert-Eaton syndrome occur in the absence of a malignancy?

Yes

No

5. How does clostridium botulinum cause paralysis of respiraroty and sekeletal muscles?

The clostridium botulinum blocks synaptic clefts

The clostridium botulinum generates a neurotoxin that inhibits glutamate

The clostridium botulinum generates a neurotoxin that inhibits the reuptake ot acetycholine

The clostridium botulinum generates a neurotoxin that inhibits the release of acetylcholine.

6. Is clostridium botulinum the same agent that is used to treat wrinkles, migraines and torticollis in the form of botox?

Yes

No

7. Do patients with MG have constant weakness or does the weakness fluctuate?

The weakness is constant

The weakness fluctuates

8. Mortality in MG is usually due to:

Falls

Respiratory compromise

Severe constipation

Cardiac failure

9. Symptoms of MG respond to the administration of what drugs?

Acetaminophen

Levadopa

Acetycholinesterase inhibitors

Simvastatin

10. What is the causative agent of botulism?

Clostridium difficile

Clostridium perfringens

Clostridium tetani

Clostridium botulinum

11. 65% of patients with myasthenia gravis have:

Thymoma

Thymic hyperplasia

15% have thymoma

Explanation

15% have thymoma

12. Patients with myasthenia gravis will initially have weakness of which muscles?

Deltoid muscles

Facial

Extraocular

Tongue

13. Will you find clostridium botulinum growing in adequately sterilized canned foods?

Yes

No

14. A 65 year old woman is found to have muscle weakness and antiacetylcholine receptor antibodies. What is the most likely diagnosis?

Botulism

Lambert-eaton syndrome

Parkinson's disease

Myasthenia gravis

Alzheimer's disease

15. Lambert-Eaton syndrome is typically a ____________ process.

Neoplastic

Malignant

Paraneoplastic

Benign

16. Clostridium botulinum is a gram _ bacillus that grown in __ conditions and produces spores.

Positive, aerobic

Negative aeorbic

Positive, anerobic

Negative, anerobic

17. What is the prevalence of myasthenia gravis?

1/1000 000 people

3/100 000 people

18. Which of the following are other uses of botox?

Blepharospasm

Hyperhydrosis

Migraine

Spasmodic torticollis

Achalasia

achalasia - esophageal aperilstalsis.

Explanation

achalasia - esophageal aperilstalsis.

Submit

19. Which of the following are other forms of treatment for MG?

Prednisone

Plasmapheresis

Resection of thymoma

Azothioprine and cyclophosphamide

Cyclosporine

Submit

20. Patients with myasthenia gravis (MG) will exhibit weakness of their extraocular muscles leading to the following symptoms:

Blindness

Blurred vision

Ptosis

Diplopia

Submit

21. Patients with Lambert-Eaton syndrome have abnormally low levels of acetylcholine in the neuromuscular junction synaptic vessels. True or false?

True

False

The acetylcholine content in the neuromuscular junction synaptic vessels is normal.

Explanation

The acetylcholine content in the neuromuscular junction synaptic vessels is normal.

22. What is the most common type of pituitary adenoma?

Prolactinoma

Null cell

Corticotropic

Somatotropic

23. Since there is adequate Acetylcholine in the vesicles why is there less acetylcholine in the synapse?

Fewer synaptic vessicles are released

Patients have autoimunity to the presynaptic calcium channels

Acetylcholine is degraded within the vessels

Submit

Neuromuscular Junction Disorders (Msq Drill 187)

1. What autoimmune disease leads to a loss of functional acetylocholine receptors at the neuromuscular junction due to autoantibodies against the acetycholine receptor?

2.

What first name or nickname would you like us to use?

2. Can the weakness of MG become generalized?

3. 60% of patients with Lambert-Eaton syndrome have:

4. Can Lambert-Eaton syndrome occur in the absence of a malignancy?

5. How does clostridium botulinum cause paralysis of respiraroty and sekeletal muscles?

6. Is clostridium botulinum the same agent that is used to treat wrinkles, migraines and torticollis in the form of botox?

7. Do patients with MG have constant weakness or does the weakness fluctuate?

8. Mortality in MG is usually due to:

9. Symptoms of MG respond to the administration of what drugs?

10. What is the causative agent of botulism?

11. 65% of patients with myasthenia gravis have:

12. Patients with myasthenia gravis will initially have weakness of which muscles?

13. Will you find clostridium botulinum growing in adequately sterilized canned foods?

14. A 65 year old woman is found to have muscle weakness and antiacetylcholine receptor antibodies. What is the most likely diagnosis?

15. Lambert-Eaton syndrome is typically a ____________ process.

16. Clostridium botulinum is a gram _____ bacillus that grown in ______ conditions and produces spores.

17. What is the prevalence of myasthenia gravis?

18. Which of the following are other uses of botox?

19. Which of the following are other forms of treatment for MG?

20. Patients with myasthenia gravis (MG) will exhibit weakness of their extraocular muscles leading to the following symptoms:

21. Patients with Lambert-Eaton syndrome have abnormally low levels of acetylcholine in the neuromuscular junction synaptic vessels. True or false?

22. What is the most common type of pituitary adenoma?

23. Since there is adequate Acetylcholine in the vesicles why is there less acetylcholine in the synapse?

16. Clostridium botulinum is a gram _ bacillus that grown in __ conditions and produces spores.