Neuromuscular Junction Disorders (Msq Drill 187)
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- 1.
What autoimmune disease leads to a loss of functional acetylocholine receptors at the neuromuscular junction due to autoantibodies against the acetycholine receptor?
- A.
SLE
- B.
Rheumatoid arthritis
- C.
Myasthenia gravis
- D.
Myositis
Correct Answer
C. Myasthenia gravis -
- 2.
65% of patients with myasthenia gravis have:
- A.
Thymoma
- B.
Thymic hyperplasia
Correct Answer
B. Thymic hyperplasiaExplanation
15% have thymomaRate this question:
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- 3.
What is the prevalence of myasthenia gravis?
- A.
1/1000 000 people
- B.
3/100 000 people
- C.
3/100 000 people
Correct Answer
C. 3/100 000 people -
- 4.
Patients with myasthenia gravis will initially have weakness of which muscles?
- A.
Deltoid muscles
- B.
Facial
- C.
Extraocular
- D.
Tongue
Correct Answer
C. Extraocular -
- 5.
Patients with myasthenia gravis (MG) will exhibit weakness of their extraocular muscles leading to the following symptoms:
- A.
Blindness
- B.
Blurred vision
- C.
Ptosis
- D.
Diplopia
Correct Answer(s)
C. Ptosis
D. Diplopia -
- 6.
Do patients with MG have constant weakness or does the weakness fluctuate?
- A.
The weakness is constant
- B.
The weakness fluctuates
Correct Answer
B. The weakness fluctuates -
- 7.
Can the weakness of MG become generalized?
- A.
Yes
- B.
No
Correct Answer
A. Yes -
- 8.
Symptoms of MG respond to the administration of what drugs?
- A.
Acetaminophen
- B.
Levadopa
- C.
Acetycholinesterase inhibitors
- D.
Simvastatin
Correct Answer
C. Acetycholinesterase inhibitors -
- 9.
Which of the following are other forms of treatment for MG?
- A.
Prednisone
- B.
Plasmapheresis
- C.
Resection of thymoma
- D.
Azothioprine and cyclophosphamide
- E.
Cyclosporine
Correct Answer(s)
A. Prednisone
B. PlasmapHeresis
C. Resection of thymoma
D. Azothioprine and cyclopHospHamide
E. Cyclosporine -
- 10.
Mortality in MG is usually due to:
- A.
Falls
- B.
Respiratory compromise
- C.
Severe constipation
- D.
Cardiac failure
Correct Answer
B. Respiratory compromise -
- 11.
What is the causative agent of botulism?
- A.
Clostridium difficile
- B.
Clostridium perfringens
- C.
Clostridium tetani
- D.
Clostridium botulinum
Correct Answer
D. Clostridium botulinum -
- 12.
Clostridium botulinum is a gram _____ bacillus that grown in ______ conditions and produces spores.
- A.
Positive, aerobic
- B.
Negative aeorbic
- C.
Positive, anerobic
- D.
Negative, anerobic
Correct Answer
D. Negative, anerobic -
- 13.
Will you find clostridium botulinum growing in adequately sterilized canned foods?
- A.
Yes
- B.
No
Correct Answer
B. No -
- 14.
How does clostridium botulinum cause paralysis of respiraroty and sekeletal muscles?
- A.
The clostridium botulinum blocks synaptic clefts
- B.
The clostridium botulinum generates a neurotoxin that inhibits glutamate
- C.
The clostridium botulinum generates a neurotoxin that inhibits the reuptake ot acetycholine
- D.
The clostridium botulinum generates a neurotoxin that inhibits the release of acetylcholine.
Correct Answer
D. The clostridium botulinum generates a neurotoxin that inhibits the release of acetylcholine. -
- 15.
Is clostridium botulinum the same agent that is used to treat wrinkles, migraines and torticollis in the form of botox?
- A.
Yes
- B.
No
Correct Answer
A. Yes -
- 16.
Which of the following are other uses of botox?
- A.
Blepharospasm
- B.
Hyperhydrosis
- C.
Migraine
- D.
Spasmodic torticollis
- E.
Achalasia
Correct Answer(s)
A. BlepHarospasm
B. Hyperhydrosis
C. Migraine
D. Spasmodic torticollis
E. AchalasiaExplanation
achalasia - esophageal aperilstalsis.Rate this question:
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- 17.
Lambert-Eaton syndrome is typically a ____________ process.
- A.
Neoplastic
- B.
Malignant
- C.
Paraneoplastic
- D.
Benign
Correct Answer
C. Paraneoplastic -
- 18.
60% of patients with Lambert-Eaton syndrome have:
- A.
Breast cancer
- B.
Small cell carcinoma of the lung
- C.
Ovarian cancer
- D.
Prostate cancer
Correct Answer
B. Small cell carcinoma of the lung -
- 19.
Can Lambert-Eaton syndrome occur in the absence of a malignancy?
- A.
Yes
- B.
No
Correct Answer
A. Yes -
- 20.
Patients with Lambert-Eaton syndrome have abnormally low levels of acetylcholine in the neuromuscular junction synaptic vessels. True or false?
- A.
True
- B.
False
Correct Answer
B. FalseExplanation
The acetylcholine content in the neuromuscular junction synaptic vessels is normal.Rate this question:
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- 21.
Since there is adequate Acetylcholine in the vesicles why is there less acetylcholine in the synapse?
- A.
Fewer synaptic vessicles are released
- B.
Patients have autoimunity to the presynaptic calcium channels
- C.
Acetylcholine is degraded within the vessels
Correct Answer(s)
A. Fewer synaptic vessicles are released
B. Patients have autoimunity to the presynaptic calcium channels -
- 22.
A 65 year old woman is found to have muscle weakness and antiacetylcholine receptor antibodies. What is the most likely diagnosis?
- A.
Botulism
- B.
Lambert-eaton syndrome
- C.
Parkinson's disease
- D.
Myasthenia gravis
- E.
Alzheimer's disease
Correct Answer
D. Myasthenia gravis -
- 23.
What is the most common type of pituitary adenoma?
- A.
Prolactinoma
- B.
Null cell
- C.
Corticotropic
- D.
Somatotropic
Correct Answer
A. Prolactinoma -
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Feb 16, 2019Quiz Edited by
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Apr 23, 2010Quiz Created by
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