Nsaids - Part 1 - Cox Enzyme Functions (Msq Drill 177)

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Questions and Answers

1.

Arachidonic acid is released from ______ .
- A.
  
  Leukotriennes
- B.
  
  Phospholipids
- C.
  
  Prostaglandin
- D.
  
  Cyclooxygenase
Correct Answer
B. pHospHolipids

Explanation
Our cell membrane plays a role in the production of arachidonic acid.

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2.

What enzyme facilitates the release of arachidonoc acid from phospholipase?
- A.
  
  Phospholipase A
- B.
  
  Phospholipase B
- C.
  
  Phospholipase C
Correct Answer
A. pHospHolipase A
3.

Are leukotrienes produced directly from phospholipids or from arachidonic acid?
- A.
  
  Leukotrienes are produced directly from phospholipase
- B.
  
  Leuknotrienes are produced from arachidonic acid
Correct Answer
B. Leuknotrienes are produced from arachidonic acid
4.

Are prostaglandins also produced from arachidonic acid?
- A.
  
  Yes
- B.
  
  No
Correct Answer
A. Yes
5.

What eznymes facilitates the prduction prostaglandins from arachidonic acid?
- A.
  
  COX 1
- B.
  
  COX 2
- C.
  
  Phospholipase B
Correct Answer(s)
A. COX 1
B. COX 2
6.

Eventually the prostaglandins form different tissue isomerase that play multiple roles in various tissues in the body. True or false?
- A.
  
  True
- B.
  
  False
Correct Answer
A. True
7.

What product of arachidonic acid plays a role in pulmonary inflammation and bronchconstriction and therefore has a role in the asthma?
- A.
  
  COX 1
- B.
  
  COX 2
- C.
  
  Prostaglandin 1
- D.
  
  Leukotrienne
- E.
  
  Thromboxane
Correct Answer
D. Leukotrienne
8.

Since prostaglandins can be manipulated by COX 1 and COX 2 to form various tissue isomerases. Which COX enzyme is responsible for maintaining the mucosa, facilitating cytoprotective secretions and increasing secretions?
- A.
  
  COX 1
- B.
  
  COX 2
Correct Answer
A. COX 1
9.

If one therefore blocks COX 1, the gastric mucosa will:
- A.
  
  Have an overwhelming supply of secretions
- B.
  
  Have no secretions and will thus erode
Correct Answer
B. Have no secretions and will thus erode
10.

Which COX enzyme causes vasodilation and thus increased perfusion to the kidneys?
- A.
  
  COX 1
- B.
  
  COX 2
- C.
  
  Both COX 1 and COX 2
Correct Answer
C. Both COX 1 and COX 2
11.

Do both COX enzymes affect microphage chemotaxis?
- A.
  
  Yes
- B.
  
  No
Correct Answer
A. Yes
12.

If you give a patient a COX inhibitor with bother COX 1 and 2 effect, this will slow down or eliminate macrophage taxis. Will this lead to increased or decreased inflammation?
- A.
  
  Increased inflammation
- B.
  
  Decreased inflammation
Correct Answer
B. Decreased inflammation
13.

If you increased the dose of the COX inhibitor will the inflammation be even more reduced?
- A.
  
  Yes
- B.
  
  No
Correct Answer
A. Yes
14.

Which COX enzyme increases fever and also increases my sense of pain?
- A.
  
  COX 1
- B.
  
  COX 2
Correct Answer
B. COX 2

Explanation
COX 2 increased fever and also increases nocicpetion.

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15.

If all I wanted was an antipyretic effect from an NSAID then I would choose:
- A.
  
  A COX 1 inhibitor
- B.
  
  A COX 2 inhibitor
Correct Answer
B. A COX 2 inhibitor

Explanation
antipyretics - drugs that reduce fever

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16.

When a patient has an ulcer, their body probably uses COX _____ in the process of wound healing.
- A.
  
  COX 1
- B.
  
  COX 2
Correct Answer
B. COX 2
17.

One COX enzyme causes platelet aggregation whilst the other inhibits platelet aggregation. Which COX enzyme inhibits platelet aggregation?
- A.
  
  COX 1
- B.
  
  COX 2
Correct Answer
B. COX 2
18.

COX 1 initiates the process that eventually leads to the production of ___________ which is responsible for platelet aggregation.
- A.
  
  Thromboxane A2
- B.
  
  Thromboxane B2
- C.
  
  Prostaglandin I2
- D.
  
  Prostaglanding E2
Correct Answer
A. Thromboxane A2
19.

COX 2 facilitates the production of ________ which is responsible for inhibiting platelet aggregation.
- A.
  
  Thromboxane B2
- B.
  
  Prostaglandin E2
- C.
  
  Prostaglandin I2
Correct Answer
C. Prostaglandin I2
20.

So, Aspirin has an effect on COX 1 or COX 2?
- A.
  
  Cox 1
- B.
  
  Cox 2
Correct Answer
A. Cox 1
21.

Do COX enzymes cause vasodilation or vasoconstriction?
- A.
  
  Vasodilation
- B.
  
  Vasoconstriction
Correct Answer
A. Vasodilation
22.

If COX enzymes cause vasodilation, what happens to renal afferent flow when a patient takes an NSAID?
- A.
  
  Increased renal afferent flow
- B.
  
  Decreased renal afferent flow
Correct Answer
B. Decreased renal afferent flow
23.

Decreased renal afferent flow will lead to:
- A.
  
  Hyperperfusion of the kidneys
- B.
  
  Hypoperfusion of the kidneys
Correct Answer
B. Hypoperfusion of the kidneys
24.

Taking an NSAID will reduce perfusion into the kidneys. The kidneys respond by raising or lowering blood pressure?
- A.
  
  Raising blood pressure
- B.
  
  Lowering blood pressure
Correct Answer
A. Raising blood pressure
25.

Therefore a patient can develop Acute renal failure due to NSAIDS. True or false?
- A.
  
  True
- B.
  
  False
Correct Answer
A. True
26.

What classes of antihypertensive medication should not be used concurrently with NSAIDS
- A.
  
  Diuretics
- B.
  
  Beta blockers
- C.
  
  Angiotensin convertine enzyme inhibitors (ACEIs)
- D.
  
  Angiotensin II receptor blockers (ARBs)
Correct Answer(s)
C. Angiotensin convertine enzyme inhibitors (ACEIs)
D. Angiotensin II receptor blockers (ARBs)
27.

We have established that COX 2 causes platelet aggregation or thrombosis. IF you gave a patient Aspirin, will this thrombotic risk be decreased?
- A.
  
  Yes
- B.
  
  No
Correct Answer
B. No
28.

What do NSAIDS cause, an increase or decrease in pottasium?
- A.
  
  Pottassium gain
- B.
  
  Pottassium loss
Correct Answer
B. Pottassium loss
29.

Eventually patients on NSAIDs will have lower potassium levela and renal tubular _____ .
- A.
  
  Acidosis
- B.
  
  Alkalosis
Correct Answer
A. Acidosis
30.

Patients on NSAIDS are at risk for analagesic nephropathy. True or false?
- A.
  
  True
- B.
  
  False
Correct Answer
A. True
31.

In general, COX enzymes perform the following functions on the kidney:
- A.
  
  Increase perfusion
- B.
  
  Maintain hydrostatic pressure
- C.
  
  Sodium secretion
- D.
  
  Control renin
- E.
  
  Aldosterone and potassium retention
Correct Answer(s)
A. Increase perfusion
B. Maintain hydrostatic pressure
C. Sodium secretion
D. Control renin
E. Aldosterone and potassium retention
32.

If you give a patient an NSAID, they will excrete more or less sodium?
- A.
  
  More sodium
- B.
  
  Less sodium
Correct Answer
B. Less sodium

Explanation
COX enzyme generally facilitate sodium excretion and potassium retention.

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33.

If you block COX enzymes by taking NSAIDs you increase or decrease leukotrienne formation?
- A.
  
  Increase
- B.
  
  Decrease
Correct Answer
A. Increase
34.

Thus, increased leukotrienne formation will result in the following symptoms.
- A.
  
  Pulmonary inflammation
- B.
  
  Bronchospasms in those who are sensitive
- C.
  
  Anaphylactoid
- D.
  
  Bronchoconstriction
Correct Answer(s)
A. Pulmonary inflammation
B. Bronchospasms in those who are sensitive
C. AnapHylactoid

Explanation
anaphylactoid - resembling anaphylaxix

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35.

A physician is considering administering an NSAID to a woman in labor. Will this lead to a quicker delivery or an inhibition of the labor?
- A.
  
  Quicker delivery
- B.
  
  Inhibited labor
Correct Answer
B. Inhibited labor

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Feb 16, 2019

Quiz Edited by
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Apr 27, 2010

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Nsaids - Part 1 - Cox Enzyme Functions (Msq Drill 177)

Arachidonic acid is released from ______ .

What enzyme facilitates the release of arachidonoc acid from phospholipase?

Are leukotrienes produced directly from phospholipids or from arachidonic acid?

Are prostaglandins also produced from arachidonic acid?

What eznymes facilitates the prduction prostaglandins from arachidonic acid?

Eventually the prostaglandins form different tissue isomerase that play multiple roles in various tissues in the body. True or false?

What product of arachidonic acid plays a role in pulmonary inflammation and bronchconstriction and therefore has a role in the asthma?

Since prostaglandins can be manipulated by COX 1 and COX 2 to form various tissue isomerases. Which COX enzyme is responsible for maintaining the mucosa, facilitating cytoprotective secretions and increasing secretions?

If one therefore blocks COX 1, the gastric mucosa will:

Which COX enzyme causes vasodilation and thus increased perfusion to the kidneys?

Do both COX enzymes affect microphage chemotaxis?

If you give a patient a COX inhibitor with bother COX 1 and 2 effect, this will slow down or eliminate macrophage taxis. Will this lead to increased or decreased inflammation?

If you increased the dose of the COX inhibitor will the inflammation be even more reduced?

Which COX enzyme increases fever and also increases my sense of pain?

If all I wanted was an antipyretic effect from an NSAID then I would choose:

When a patient has an ulcer, their body probably uses COX _____ in the process of wound healing.

One COX enzyme causes platelet aggregation whilst the other inhibits platelet aggregation. Which COX enzyme inhibits platelet aggregation?

COX 1 initiates the process that eventually leads to the production of ___________ which is responsible for platelet aggregation.

COX 2 facilitates the production of ________ which is responsible for inhibiting platelet aggregation.

So, Aspirin has an effect on COX 1 or COX 2?

Do COX enzymes cause vasodilation or vasoconstriction?

If COX enzymes cause vasodilation, what happens to renal afferent flow when a patient takes an NSAID?

Decreased renal afferent flow will lead to:

Taking an NSAID will reduce perfusion into the kidneys. The kidneys respond by raising or lowering blood pressure?

Therefore a patient can develop Acute renal failure due to NSAIDS. True or false?

What classes of antihypertensive medication should not be used concurrently with NSAIDS

We have established that COX 2 causes platelet aggregation or thrombosis. IF you gave a patient Aspirin, will this thrombotic risk be decreased?

What do NSAIDS cause, an increase or decrease in pottasium?

Eventually patients on NSAIDs will have lower potassium levela and renal tubular _____ .

Patients on NSAIDS are at risk for analagesic nephropathy. True or false?

In general, COX enzymes perform the following functions on the kidney:

If you give a patient an NSAID, they will excrete more or less sodium?

If you block COX enzymes by taking NSAIDs you increase or decrease leukotrienne formation?

Thus, increased leukotrienne formation will result in the following symptoms.

A physician is considering administering an NSAID to a woman in labor. Will this lead to a quicker delivery or an inhibition of the labor?