Osteoporosis Pharmacology (Msq Drill 150)
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- 1.
Which of the following are drugs or classes of drugs that can induce osteporosis?
- A.
Cheotherapy
- B.
Steroids such as gluccocorticoid
- C.
Immunosuppresants used in organ transplantation
- D.
Excess thyroid replacement
- E.
Long term heparin
Correct Answer(s)
A. Cheotherapy
B. Steroids such as gluccocorticoid
C. Immunosuppresants used in organ transplantation
D. Excess thyroid replacement
E. Long term heparin -
- 2.
Which of the following also can cause osteoporosis?
- A.
Proton pump inhibitors such as omeprazole
- B.
SSRIs
- C.
Seizure medications
- D.
Steroids
- E.
Drugs for hyperthyroidism
Correct Answer(s)
A. Proton pump inhibitors such as omeprazole
B. SSRIs
C. Seizure medications
D. SteroidsExplanation
drugs for hypothyroidism are associated with osteoporosis if they are given in excess.Rate this question:
-
- 3.
Why do we give calcium and vitamin D to women either at risk for or who have osteoporosis?
- A.
To encourage bone resorption
- B.
To maintain bone
Correct Answer
B. To maintain bone -
- 4.
What is the daily requirement for elemental calcium?
- A.
400-800mg
- B.
800-1000mg
- C.
1000-1500mg
Correct Answer
C. 1000-1500mg -
- 5.
Calcium can decreased the absorption of which of the following drugs?
- A.
Levothyroxine
- B.
Fluoroquinolones
- C.
Tetracyclines
- D.
Bisphophonates
- E.
Propylthiouracil
Correct Answer(s)
A. Levothyroxine
B. Fluoroquinolones
C. Tetracyclines
D. BispHopHonates -
- 6.
If a patient has hypercalciuria, should you administer calcium?
- A.
Yes
- B.
No
Correct Answer
B. No -
- 7.
Which of the following are side effects of calcium suplementation?
- A.
Gas
- B.
Constipation
- C.
Diarrhea
- D.
Nephrolithiasis
Correct Answer(s)
A. Gas
B. Constipation
D. NepHrolithiasis -
- 8.
To maximise absorption of calcium, it shoulde be taken:
- A.
Once a day
- B.
Twice a day
Correct Answer
B. Twice a day -
- 9.
Which of the following types of calcium supplements is the cheapest and has the highest amount of elemental calcium by weight?
- A.
Calcium carbonate
- B.
Calcium citrate
- C.
Calcium phosphate
Correct Answer
A. Calcium carbonate -
- 10.
Which of the following types of calcium supplements causes less constipation but is also the most expensive?
- A.
Calcium carbonate
- B.
Calcium citrate
- C.
Calcium phosphate
Correct Answer
C. Calcium pHospHate -
- 11.
Which of the following calcium supplements needs acid to absorb and should therefore not be taken with proton pump inhibitors. It should be taken with food.
- A.
Calcium carbonate
- B.
Calcium citrate
- C.
Calcium phosphate
Correct Answer
A. Calcium carbonate -
- 12.
Which of the following does not need acid for absorption but has less elemental calcium and is more expensive?
- A.
Calcium carbonate
- B.
Calcium citrate
- C.
Calcium phosphate
Correct Answer
C. Calcium pHospHate -
- 13.
Patients less than 50 years old should take ________ of vitamin D per day.
- A.
400-800IU
- B.
800-1000IU
- C.
1000-1500IU
Correct Answer
B. 800-1000IU -
- 14.
Is hypercalciuria and hypercalcemia also a contraindicationfor Vitamin D?
- A.
Yes
- B.
No
Correct Answer
A. Yes -
- 15.
If you take a high dose of vitamin D will it increase or decrease your bone mineral density?
- A.
Increase
- B.
Decrease
Correct Answer
B. Decrease -
- 16.
1 mcg of Vit D is = to how many international units?
- A.
20
- B.
40
- C.
60
- D.
80
- E.
100
Correct Answer
B. 40 -
- 17.
Multivitamins usually have about how much Vitamin D?
- A.
400-800IU
- B.
800-1000OIU
Correct Answer
A. 400-800IU -
- 18.
Vitamin D is usually supplied as Vit D2 and Vit D3. Which one is over the counter?
- A.
D2
- B.
D3
Correct Answer
B. D3 -
- 19.
Which are the correct pairings?
- A.
Vit D2 - cholecalciferol
- B.
Vit D2 - ergocalciferol
- C.
Vit D3 - ergocalciferol
- D.
Vit D3 - cholecalciferol
Correct Answer(s)
B. Vit D2 - ergocalciferol
D. Vit D3 - cholecalciferol -
- 20.
There are some higher potency vitamind D that are used to treat renal osteodystrophy. these include which of the following:
- A.
25-hydroxy D3 - calcifediol
- B.
25-hydroxy D2 calciferol
- C.
1,25 dihydroxyD3 - calitriol
Correct Answer(s)
A. 25-hydroxy D3 - calcifediol
C. 1,25 dihydroxyD3 - calitriol -
- 21.
For post menopausal women will estrogen replacement therapy be indicated as a way to maintain bone in the prevention of osteoporosis?
- A.
Yes
- B.
No
Correct Answer
A. Yes -
- 22.
A T score between -2.5 and -1 is osteopenia or osteoporosis?
- A.
Osteopenia
- B.
Osteoporosis
Correct Answer
A. Osteopenia -
- 23.
Should all patients with osteopenia be immediately started on osteoporosis treatment?
- A.
No, there is no indication
- B.
Yes, if they have a risk factor
Correct Answer
B. Yes, if they have a risk factor -
- 24.
A patient with osteopenia and one risk factor should be started on treatment. Which of the following could be one of the risk factors?
- A.
Secondary causes such as steroid use
- B.
History of a fracture
- C.
Family history of osteoporosis related fractures
- D.
High 10 year probablity of fracture
Correct Answer(s)
A. Secondary causes such as steroid use
B. History of a fracture
D. High 10 year probablity of fracture -
- 25.
Which of the following are antiresorptive drugs used to treat osteoporosis?
- A.
Alendronate (fosamax)
- B.
Risedronate (actonel)
- C.
Ibandronate (boniva)
- D.
Zoledronic acid (reclast)
- E.
Raloxifene (evista)
Correct Answer(s)
A. Alendronate (fosamax)
B. Risedronate (actonel)
C. Ibandronate (boniva)
D. Zoledronic acid (reclast) -
- 26.
Bisphosphonates are antiresorptive agents that work to inhibit:
- A.
Osteoblasts
- B.
Osteoclasts
Correct Answer
B. Osteoclasts -
- 27.
Patients with which of the following conditions should not take bisphosphonates?
- A.
Hypocalcemia
- B.
Renal impairment
- C.
Esophageal abnormalities
- D.
Inability to remain upright for at least 30 minutes post dose
Correct Answer(s)
A. Hypocalcemia
B. Renal impairment
C. EsopHageal abnormalities
D. Inability to remain upright for at least 30 minutes post dose -
- 28.
A patient with a creatnine clearance of less than _______ should not take bisphosphonates.
- A.
15
- B.
30
- C.
40
- D.
45
Correct Answer
B. 30 -
- 29.
Should bisphosphonates be taken with food?
- A.
Yes, they should always be taken with food with a FULL glass of water
- B.
No, they should be taken on an empty stomach with a FULL glass of water
Correct Answer
B. No, they should be taken on an empty stomach with a FULL glass of water -
- 30.
Is it appropriate to tall a patient that they should not lie down for at least 30 minutes after taking a bisphosphonate and that if they should lie down they should do so after the first food of the day is eaten?
- A.
Yes, this is appropriate patient education
- B.
No, this is inappropriate patient education
Correct Answer
A. Yes, this is appropriate patient education -
- 31.
If a patient taking a bisphosphonate starts to have epigastric pain, when should they report it?
- A.
At the next doctor's appointment
- B.
At their earliest convenience
- C.
Immidately - STAT
Correct Answer
C. Immidately - STAT -
- 32.
Osteonecrosis of the jaw is a common side effect of bisphosphonates. True or false?
- A.
True, it is a common side effect
- B.
False, it is a rare side effect
Correct Answer
B. False, it is a rare side effect -
- 33.
Calcitonin is also used in the treatment of osteoporosis. Is it an antiresorptive or anabolic agent?
- A.
Antiresorptive
- B.
Anabolic
Correct Answer
A. Antiresorptive -
- 34.
Clacitonin reduces the risk of _______ fracture and is thought to also have an ANALGESIC effect.
- A.
Hip
- B.
Elbow
- C.
Distal radius
- D.
Vertebral
Correct Answer
D. Vertebral -
- 35.
What class of drug is raloxifene (evista) that is also used in the treatment of osteoporosis?
- A.
Antiresorptive
- B.
Anabolic
- C.
Selective estrogen receptor modifier
Correct Answer
C. Selective estrogen receptor modifier -
- 36.
Raloxifene (evista) is indicated for ______________ of osteoporosis.
- A.
Prevention only
- B.
Treatment only
- C.
Prevention and treatment
Correct Answer
C. Prevention and treatment -
- 37.
In the breast and centrally what is the mechanism of action of raloxifene (evista?)
- A.
Estrogen agonist
- B.
Estrogen antagonist
Correct Answer
B. Estrogen antagonist -
- 38.
What about in the liver and bone, what is the mechanism of action of raloxifene (evista?)
- A.
Estrogen agonist
- B.
Estrogen antagonist
Correct Answer
A. Estrogen agonist -
- 39.
Because raloxifene works in the liver, is it necessary to monitor the patient's lipid profile?
- A.
Yes
- B.
No
Correct Answer
A. Yes -
- 40.
Teriparatide (forte) is an _________ agent that is used to treat osteoporosis.
- A.
Antiresorptive
- B.
Anabolic
- C.
Selective estrogen receptor modifier
Correct Answer
B. AnabolicExplanation
It is the only available anabolic agent.Rate this question:
-
- 41.
Therefore teriparatide (forteo) stimulates bone growth. True or false?
- A.
True
- B.
False
Correct Answer
A. True -
- 42.
Which of the following should not take teriparatide (forteo?) Patients with:
- A.
Metabolic bone disease
- B.
Hypercalcemia
- C.
Bone malignancy
- D.
Hyperparathyroidism
- E.
Children or pregnant women
Correct Answer(s)
A. Metabolic bone disease
B. Hypercalcemia
C. Bone malignancy
D. Hyperparathyroidism
E. Children or pregnant women -
- 43.
Can women who are breast feeding take teriparatide (forteo)?
- A.
Yes
- B.
No
Correct Answer
A. Yes -
- 44.
Teriparatide (forteo) is basically used for patients who are at a very high risk of osteoporosis. True of false?
- A.
True
- B.
False
Correct Answer
A. True -
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Feb 16, 2019Quiz Edited by
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