Quiz 10

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1.

Consider this DNA sequence. What will its RNA transcript be?
- A.
  
  UACUUAAAUUUUCUUAAUAAAUUAUAGUUA
- B.
  
  ATGAATTTAAAAGAATTATTTAATATCAAT
- C.
  
  AUGAAUUUAAAAGAAUUAUUUAAUAUCAAU
- D.
  
  UTGUUTTTUUUUGUUTTUTTTUUTUTCUUT
Correct Answer
C. AUGAAUUUAAAAGAAUUAUUUAAUAUCAAU

Explanation
The transcript will be an exact copy of the coding strand (ie, the one that starts with a start codon {ATG}), but the thymines (T) will be replaced with uracil (U).

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2.

What is the protein sequence of the RNA transcript generated in Question 1?
- A.
  
  MET ASN LEU LYS GLU LEU PHE ASN ILE ASN
- B.
  
  TYR LEU ASN PHE LEU ASN LYS LEU STOP
- C.
  
  MET ASN LEU PHE LEU ASN LYS LEU STOP
- D.
  
  MET ASN LEU PHE LEU ASN LYS LEU STOP
Correct Answer
A. MET ASN LEU LYS GLU LEU pHE ASN ILE ASN

Explanation
Using the codon table, translate the triplet codes from the coding strand

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3.

A mutation occurs in the DNA sequence from Question 1. Nucleotide number 9 is now a "G". What type of mutation is this?
- A.
  
  Missense mutation
- B.
  
  Nonsense mutation
- C.
  
  Silent mutation
- D.
  
  Frameshift mutation
Correct Answer
C. Silent mutation

Explanation
Nuc #9 is an A, and it is part of the codon TTA (leucine). If it is changed to a G, it will now generate a TTG codon (leucine). Since this mutation will still result in the addition of leucine, it is silent.

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4.

Another mutation occurs subsequently, and nucleotide number 9 is deleted entirely so the sequence is one base shorter overall. What is the resulting protein sequence?
- A.
  
  MET ASN LEU LYS GLU LEU PHE ASN ILE ASN
- B.
  
  TYR LEU ASN PHE LEU ILE ASN TYR MET
- C.
  
  MET TYR LEU ASN PHE LEU ILE ASN TYR MET
- D.
  
  MET ASN LEU LYS ASN TYR LEU ILE SER
Correct Answer
D. MET ASN LEU LYS ASN TYR LEU ILE SER

Explanation
Losing nucleotide #9 will alter the reading frame and result in new codons downstream of the mutation. Using the codon table, translate the new sequence (atgaatttaaagaattatttaatatcaat)

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5.

What type of mutation occurred in Question 4?
- A.
  
  Missense mutation
- B.
  
  Silent mutation
- C.
  
  Nonsense Mutation
- D.
  
  Frameshift Mutation
Correct Answer
D. Frameshift Mutation

Explanation
because there was a deletion that was not a multiple of 3 that resulted in a change of reading frame, this is a frameshift mutation.

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Jan 24, 2013

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Apr 14, 2011

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Quiz 10

Consider this DNA sequence. What will its RNA transcript be?

What is the protein sequence of the RNA transcript generated in Question 1?

A mutation occurs in the DNA sequence from Question 1. Nucleotide number 9 is now a "G". What type of mutation is this?

Another mutation occurs subsequently, and nucleotide number 9 is deleted entirely so the sequence is one base shorter overall. What is the resulting protein sequence?

What type of mutation occurred in Question 4?