Steroids (Msq Drill 171)
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- 1.
Which part of the adrenal gland produces epinephrine and norpeinephrine?
- A.
Medulla
- B.
Cortex
Correct Answer
A. Medulla -
- 2.
The adrenal cortex produces adrenal corticosteroids. Namely these are:
- A.
Aldosterone
- B.
Glucocorticoids
- C.
Gonadocorticoids
- D.
Mineralocorticoid
- E.
Prednisone
Correct Answer(s)
A. Aldosterone
B. Glucocorticoids
C. Gonadocorticoids
D. MineralocorticoidExplanation
mineralocorticoid is aldosterone.Rate this question:
-
- 3.
Gluccocorticoids are produced in the:
- A.
Glomerulosa
- B.
Fasciculata
- C.
Reticularis
Correct Answer
B. Fasciculata -
- 4.
Which of the following is/are produce in the reticularis
- A.
Aldosterone
- B.
Gonadocorticoids
Correct Answer
B. Gonadocorticoids -
- 5.
Aldosterone or minerlocorticoid is produced in the glomerulosa. True or false?
- A.
True
- B.
False
Correct Answer
A. True -
- 6.
Which of the following are involved in the hypothalamic-pituitary-adrenal axis?
- A.
Corticotropin releasing factor (CRF)
- B.
Adrenocorticotropic hormone
- C.
Cortisol
- D.
Thyroid stimulating hormone
Correct Answer(s)
A. Corticotropin releasing factor (CRF)
B. Adrenocorticotropic hormone
C. Cortisol -
- 7.
The ____________ releases corticotropin releasing factor when cortisol level is low.
- A.
Hypothalamus
- B.
Pituitary gland
- C.
Adrenal gland
Correct Answer
A. Hypothalamus -
- 8.
During a stressful situation is cortisol upregulated or downregulated?
- A.
Upregulated
- B.
Downregulated
Correct Answer
A. Upregulated -
- 9.
Does a short term increase of cortisol result in feedback inhibition?
- A.
Yes
- B.
No
Correct Answer
B. No -
- 10.
Above suprophysiologc doses cortisol will cuase feedback inhibition. What is considered a suproaphyisiologic dose of cortisol?
- A.
>20mg hydrocortison/day
- B.
>30mg hydrocortisone/day
- C.
>40mg hydrocortisone/day
Correct Answer
A. >20mg hydrocortison/day -
- 11.
The maximum stress induced production of cortisol is approximately ______ over 7-10 days.
- A.
50mg/24hr
- B.
100.mg/24hr
- C.
150mg/24hr
- D.
200mg/24hr
- E.
250mg/24hr
Correct Answer
D. 200mg/24hr -
- 12.
A patient has an abnormally high level of adrenocroticotropic hormone (ACTH), measuring the CRF will confirm that the pituitary gland is the source of the abnormality. True or false?
- A.
True
- B.
False
Correct Answer
A. TrueExplanation
The hypothalamus releases CRF in response to the pituitary gland.Rate this question:
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- 13.
If adrenocorticosteroids are low, the pituitary gland releases ACTH which will cause an increased production of adrenocroticosteroids by the:
- A.
Adrenal medulla
- B.
Adrenal cortex
Correct Answer
B. Adrenal cortex -
- 14.
The production of cortisol/sorticosteroids is highest in the AM or PM?
- A.
AM
- B.
PM
Correct Answer
A. AM -
- 15.
Adrenocorticotropic hormone is released by the pituitary gland. It also causes an increase in mealnin production and hyperpigmentation. When it does this is it acting as _________ .
- A.
Melanin
- B.
Melatonin
- C.
A melanocortin
Correct Answer
C. A melanocortinExplanation
This explains why patients with primary Addison's disease have hyperpigmentation.Rate this question:
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- 16.
Does cortisol cause a negative feedbacm inhibition of the hypothalamic and pituitary activity?
- A.
Yes
- B.
No
Correct Answer
A. Yes -
- 17.
Normal non-stresed individuals will produce _______ of cortisol. Stressed individuals will produce up to 200mg/24hrs.
- A.
5mg
- B.
10-30mg
- C.
100mg
- D.
150mg
Correct Answer
B. 10-30mg -
- 18.
Is cortisol metabolism CYP dependant?
- A.
Yes
- B.
No
Correct Answer
A. YesExplanation
Inducers will lead to a need to increase the amount of cortisol.Rate this question:
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- 19.
What is the best time to administer cortisol so that the hypothalamic pituitary axis is not suppressed.
- A.
AM
- B.
PM
Correct Answer
A. AM -
- 20.
Which receptor has more affinity for cortisol, the mineralocorticoid receptor or the gluccocorticoid receptor?
- A.
Mineralocorticoid receptor
- B.
Gluccocorticoid receptor
Correct Answer
A. Mineralocorticoid receptor -
- 21.
Where does initial suppression of the HPA axis start?
- A.
Mineralocorticoid receptor
- B.
Gluccocorticoid receptor
Correct Answer
A. Mineralocorticoid receptor -
- 22.
So, late phase adrenal suppression occurs at the glucocorticoid receptor?
- A.
Yes
- B.
No
Correct Answer
A. Yes -
- 23.
What effect does the mineralocorticoid receptor have on sodium?
- A.
Decreases Na+ leading to diuresis, hypovolemia and hypotension
- B.
Increases Na+ leading to retention, hypervolemia and hypertension
Correct Answer
B. Increases Na+ leading to retention, hypervolemia and hypertension -
- 24.
Does mineralocorcoid cause K+ loss or retention?
- A.
K+ loss
- B.
K+ retention
Correct Answer
A. K+ loss -
- 25.
Taking a gluccocrticoid will increase blood sugar levels. True or false?
- A.
Yes, this is due to insulin antagonism
- B.
No, it has no effect on blood suar levels
Correct Answer
A. Yes, this is due to insulin antagonism -
- 26.
Gluccorcoticoids cause insuloin antagonism, therefore there is more circulating blood sugar leading to more fat deposition or redistribution of fat. What are common names used to describe this phenomenon?
- A.
Moon face
- B.
Buffalo hump
- C.
Cauliflower ears
- D.
Cushingoid
Correct Answer(s)
A. Moon face
B. Buffalo hump
D. Cushingoid -
- 27.
Glucocorticoids are involved in the following functions>
- A.
Gluconeogenesis
- B.
Protein anabolism
- C.
Protein catabolism
- D.
Lipolysis
Correct Answer(s)
A. Gluconeogenesis
C. Protein catabolism
D. Lipolysis -
- 28.
Glucocorticoid also have the following functions:
- A.
Anti inflammatory
- B.
Decreased anti body production & cytokines
- C.
Decreased WBC margination (leukocytosis)
- D.
Decreased COX 2 expression
- E.
Increased apoptosis in neoplams
Correct Answer(s)
A. Anti inflammatory
B. Decreased anti body production & cytokines
C. Decreased WBC margination (leukocytosis)
D. Decreased COX 2 expression
E. Increased apoptosis in neoplams -
- 29.
Fludrocortisone (florinef) is primarily a :
- A.
Glucocorticoid
- B.
Mineralocorticoid
- C.
Gonadocorticoid
Correct Answer
B. Mineralocorticoid -
- 30.
What is aldosterone?
- A.
Mineralocorticoid
- B.
Glucocorticoid
- C.
Gonadocroticoid
Correct Answer
A. Mineralocorticoid -
- 31.
Hydrocortisone, cortisone and prednisone are:
- A.
Primarily mineralocorticoid
- B.
Mixed
- C.
Primarily glococorticoid
Correct Answer
B. Mixed -
- 32.
Methylprednisolone is:
- A.
Primarily mineralocorticoid
- B.
Mixed
- C.
Primary glucorcorticoid and short acting
Correct Answer
C. Primary glucorcorticoid and short acting -
- 33.
The following drugs are all intermediate to long acting gluccocorticoids. Which one is most often used for CNS penetration?
- A.
Triamnicolone (kenalog)
- B.
Bethamethasone (diprosone)
- C.
Dexamethasone
Correct Answer
C. Dexamethasone -
- 34.
Which of the following are ACUTE sie effcts of corticosteroids?
- A.
Hypoerglycemia
- B.
Hypokalemia
- C.
Psychois/depression/euphoria
- D.
Increased risk of infection and superinfection
- E.
Decreased appetitie
Correct Answer(s)
A. Hypoerglycemia
B. Hypokalemia
C. Psychois/depression/eupHoria
D. Increased risk of infection and superinfection
E. Decreased appetitieExplanation
Appetite if increased.Rate this question:
-
- 35.
Can corticosteroids cause acne?
- A.
Yes
- B.
No
Correct Answer
A. Yes -
- 36.
Do corticosteroids cause sedation?
- A.
Yes, they can cuse sedation
- B.
No, they actually cause agitation
Correct Answer
B. No, they actually cause agitation -
- 37.
Chronic side effects of corticosteroids incude:
- A.
Poor wound healing
- B.
Glaucoma & osteoporosis
- C.
Cushingoid appearance and striae
- D.
Weight gain and gastric erosion
- E.
HPA suppression
Correct Answer(s)
A. Poor wound healing
C. Cushingoid appearance and striae
D. Weight gain and gastric erosion
E. HPA suppression -
- 38.
How do we prevent HPA suppression in a patient that has been taking corticosteroids for >7 days?
- A.
Stop the medication suddenly in order to drop the levels
- B.
Taper the medication
Correct Answer
B. Taper the medication -
- 39.
If a patient is taking steroids chronically and then they experience increased stress, will their dose need to be increased or decreased?
- A.
Increased
- B.
Decreased
Correct Answer
A. Increased -
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Feb 16, 2019Quiz Edited by
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