Know About Rippling Muscle Disease Quiz
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At what age do symptoms of Rippling Muscle Disease generally begin?
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Infancy
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Early childhood
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Late childhood or adolescence
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Adulthood
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Test your knowledge of Rippling Muscle Disease (RMD) and with this informative quiz! Rippling muscle disease is a rare condition that primarily affects the muscles. This quiz consists of questions that will challenge your understanding of this condition. You'll explore the characteristic signs and symptoms of RMD, such as increased muscle irritability, percussion-induced rapid contractions, and visible rippling of See morethe muscles.
Additionally, you'll learn about common experiences like fatigue, muscle cramps, and stiffness, which are often triggered by strenuous activity or exposure to cold temperatures. You'll also delve into the genetic basis of Rippling Muscle Disease. Challenge yourself with this quiz to test your knowledge of Rippling Muscle Disease and caveolinopathies. Expand your understanding of this rare condition and gain insight into the impact it has on individuals and their families. Good luck!
Quiz Preview
- 2.
Rippling muscle disease is characterized by which of the following muscle abnormalities?
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Weakness and atrophy
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Tenderness and pain
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Increased muscle irritability and rippling
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Loss of sensation and numbness
Correct Answer
A. Increased muscle irritability and ripplingExplanation
Rippling muscle disease is a rare genetic disorder characterized by increased muscle irritability and rippling. This means that the affected individual experiences involuntary muscle contractions and visible rippling of the muscles under the skin. This abnormal muscle activity can cause discomfort and may be triggered by movement or touch. Weakness and atrophy, tenderness and pain, and loss of sensation and numbness are not typically associated with rippling muscle disease.Rate this question:
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- 3.
Which of the following is NOT a common symptom of Rippling Muscle Disease?
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Fatigue
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Muscle cramps
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Muscle stiffness
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Vision problems
Correct Answer
A. Vision problemsExplanation
Rippling Muscle Disease is a genetic disorder that affects the muscles. Common symptoms of this condition include muscle cramps, muscle stiffness, and fatigue. However, vision problems are not typically associated with Rippling Muscle Disease. This means that vision problems are NOT a common symptom of this condition.Rate this question:
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- 4.
Rippling muscle disease can be caused by changes in which gene?
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CAV1
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CAV2
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CAV3
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CAV4
Correct Answer
A. CAV3Explanation
Rippling muscle disease is a genetic disorder characterized by muscle contractions and rippling movements. The correct gene associated with this disease is CAV3. Changes or mutations in the CAV3 gene can disrupt the normal function of muscle cells, leading to the symptoms of rippling muscle disease. CAV1, CAV2, and CAV4 are not known to be directly involved in the development of this particular disorder.Rate this question:
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- 5.
How is Rippling Muscle Disease usually inherited?
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Autosomal dominant
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Autosomal recessive
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X-linked recessive
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Mitochondrial inheritance
Correct Answer
A. Autosomal dominantExplanation
Rippling Muscle Disease is usually inherited in an autosomal dominant manner. This means that a person only needs to inherit one copy of the mutated gene from either parent to develop the disease. The mutated gene is located on one of the autosomes (non-sex chromosomes) and can be passed down from generation to generation. Unlike autosomal recessive inheritance, where both copies of the gene need to be mutated, autosomal dominant inheritance allows for the disease to be passed on even if only one parent carries the mutated gene.Rate this question:
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- 6.
Rippling muscle disease can also cause features of other conditions known as:
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Cachexia
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Cardiomyopathies
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Dysautonomia
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Caveolinopathies
Correct Answer
A. CaveolinopathiesExplanation
Rippling muscle disease is a rare genetic disorder that primarily affects the muscles. It is characterized by rippling or wave-like movements that occur under the skin in response to muscle contractions. In addition to these muscle abnormalities, individuals with rippling muscle disease may also exhibit features of other conditions known as caveolinopathies. Caveolinopathies are a group of genetic disorders that affect the caveolin proteins, which play a role in the formation of caveolae, small invaginations in the cell membrane. These conditions can cause a variety of symptoms, including muscle weakness, cardiomyopathies (diseases of the heart muscle), dysautonomia (dysfunction of the autonomic nervous system), and other related problems.Rate this question:
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- 7.
Which of the following conditions is NOT considered a caveolinopathy?
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Limb-girdle muscular dystrophy 1C
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Isolated hyperCKemia
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CAV3-related distal myopathy
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Duchenne muscular dystrophy
Correct Answer
A. Duchenne muscular dystrophyExplanation
Duchenne muscular dystrophy is not considered a caveolinopathy because it is caused by mutations in the dystrophin gene, not the caveolin gene. Caveolinopathies are a group of genetic disorders that result from mutations in the caveolin gene, specifically caveolin-3 in the case of CAV3-related distal myopathy. Limb-girdle muscular dystrophy 1C and isolated hyperCKemia are also considered caveolinopathies as they are caused by mutations in the caveolin gene.Rate this question:
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- 8.
Rippling muscle disease is characterized by percussion-induced rapid contractions, which refers to:
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Rapid blinking of the eyes
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Rapid heartbeat
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Rapid twitching of the muscles
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Rapid movement of the joints
Correct Answer
A. Rapid blinking of the eyesExplanation
Rippling muscle disease is a condition that is characterized by percussion-induced rapid contractions. These contractions cause a rippling effect in the muscles, leading to rapid twitching. However, this question specifically asks for the symptom that refers to rapid blinking of the eyes. Therefore, the correct answer is rapid blinking of the eyes, as this is a characteristic symptom of rippling muscle disease.Rate this question:
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- 9.
Which of the following is a common trigger for fatigue and muscle stiffness in Rippling Muscle Disease?
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Exposure to hot temperatures
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Emotional stress
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Strenuous activity
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Lack of sleep
Correct Answer
A. Strenuous activityExplanation
Strenuous activity is a common trigger for fatigue and muscle stiffness in Rippling Muscle Disease. This is because the excessive physical exertion puts strain on the muscles, leading to muscle fatigue and stiffness. The muscles in individuals with Rippling Muscle Disease are particularly sensitive to activity, causing them to become easily fatigued and stiffened after strenuous exercise.Rate this question:
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- 10.
Rippling muscle disease may cause hypertrophy, which means:
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Muscle weakness and wasting
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Enlargement of some muscles
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Loss of muscle coordination
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Joint deformities
Correct Answer
A. Enlargement of some musclesExplanation
Rippling muscle disease may cause hypertrophy, which refers to the enlargement of certain muscles. This means that individuals with this condition may experience an increase in the size of specific muscle groups. It is important to note that hypertrophy is different from muscle weakness and wasting, loss of muscle coordination, or joint deformities, which are not typically associated with this disease.Rate this question:
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- 11.
Which gene mutation is associated with Rippling Muscle Disease?
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RYR1
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CACNA1S
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DMPK
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ATP2A1
Correct Answer
A. RYR1Explanation
The correct answer is RYR1. Rippling Muscle Disease is primarily caused by mutations in the RYR1 gene, which encodes the ryanodine receptor 1 protein. Mutations in other genes like CACNA1S, DMPK, and ATP2A1 can lead to different muscle diseases but not specifically Rippling Muscle Disease.Rate this question:
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- 12.
What is the main clinical feature of Rippling Muscle Disease?
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Muscle weakness
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Rippling or wave-like muscle contractions
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Joint stiffness
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Cardiomyopathy
Correct Answer
A. Rippling or wave-like muscle contractionsExplanation
The correct answer is Rippling or wave-like muscle contractions. Rippling Muscle Disease is characterized by rippling or wave-like muscle contractions that are triggered by muscle stretching or percussion. Muscle weakness, joint stiffness, and cardiomyopathy are not the main clinical features of this specific disease.Rate this question:
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- 13.
How is Rippling Muscle Disease diagnosed?
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Blood test
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Muscle biopsy
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Electromyography (EMG)
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X-ray imaging
Correct Answer
A. Electromyography (EMG)Explanation
The correct answer is Electromyography (EMG). Rippling Muscle Disease is typically diagnosed through electromyography, which measures the electrical activity of muscles. Blood tests, muscle biopsies, and X-ray imaging may be used for additional evaluation, but EMG is the primary diagnostic tool.Rate this question:
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- 14.
Is Rippling Muscle Disease inherited?
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Yes, it is inherited in an autosomal dominant manner
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No, it is not inherited
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Yes, it is inherited in an autosomal recessive manner
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Yes, it is inherited in an X-linked recessive manner
Correct Answer
A. Yes, it is inherited in an autosomal dominant mannerExplanation
The correct answer is Yes, it is inherited in an autosomal dominant manner. Rippling Muscle Disease is typically inherited in an autosomal dominant pattern, meaning an affected individual has a 50% chance of passing the mutated gene to each of their children. It is not inherited in an autosomal recessive or X-linked recessive manner.Rate this question:
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- 15.
What is the treatment approach for Rippling Muscle Disease?
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Drug therapy
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Physical therapy
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Surgical intervention
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No specific treatment is available
Correct Answer
A. No specific treatment is availableExplanation
The correct answer is No specific treatment is available. Currently, there is no specific treatment for Rippling Muscle Disease. Management mainly involves symptom relief and supportive measures such as physical therapy and specialized orthopedic interventions if necessary. Drug therapy and surgical interventions may be employed for associated symptoms or complications but not as a direct treatment for the disease itself.Rate this question:
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- 16.
Which of the following is not a name commonly used for Rippling Muscle Disease?
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Rippling muscle syndrome
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Rippling muscle dystrophy
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Cavé disease
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Nebula disease
Correct Answer
A. Rippling muscle dystrophyExplanation
The correct answer is Rippling muscle dystrophy. Rippling Muscle Disease is sometimes referred to as Rippling muscle syndrome, Cavé disease, or Nebula disease. Rippling muscle dystrophy is not a commonly used name for this specific disease.Rate this question:
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- 17.
Are there any known preventive measures for Rippling Muscle Disease?
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Yes, regular exercise can prevent the development of the disease
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No, there are no known preventive measures
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Genetic counseling and testing can prevent transmission to offspring
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Vitamin and mineral supplementation can reduce the risk
Correct Answer
A. No, there are no known preventive measuresExplanation
The correct answer is No, there are no known preventive measures. Rippling Muscle Disease is primarily caused by genetic mutations, and currently, there are no known preventive measures to avoid the development of the disease. Genetic counseling and testing can help in family planning, but it doesn't prevent the occurrence of the disease itself.Rate this question:
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- 18.
Can Rippling Muscle Disease lead to respiratory complications?
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Yes, it commonly causes respiratory failure
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No, it does not affect the respiratory system
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Respiratory complications are rare
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Respiratory issues may occur in some cases
Correct Answer
A. Respiratory issues may occur in some casesExplanation
The correct answer is Respiratory issues may occur in some cases. While respiratory complications are not a defining feature of Rippling Muscle Disease, in some cases, individuals may experience respiratory issues such as breathing difficulties or reduced respiratory muscle strength. However, it is not a commonly occurring symptom and can vary in severity among affected individuals.Rate this question:
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- 19.
Which type of muscle fibers are primarily affected in Rippling Muscle Disease?
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Type I (slow-twitch) muscle fibers
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Type IIa (fast-twitch oxidative) muscle fibers
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Type IIb (fast-twitch glycolytic) muscle fibers
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All muscle fiber types are equally affected
Correct Answer
A. Type IIa (fast-twitch oxidative) muscle fibersExplanation
The correct answer is Type IIa (fast-twitch oxidative) muscle fibers. Rippling Muscle Disease primarily affects Type IIa muscle fibers, which are fast-twitch oxidative fibers involved in sustained contractions. Type I muscle fibers are less affected, and Type IIb fibers may also be involved, but Type IIa fibers are primarily affected.Rate this question:
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- 20.
Do all individuals with Rippling Muscle Disease experience muscle rippling?
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Yes, it is a universal symptom
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No, some individuals may not experience muscle rippling
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Muscle rippling is only observed during muscle contraction
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Muscle rippling is observed only in children
Correct Answer
A. No, some individuals may not experience muscle ripplingExplanation
The correct answer is No, some individuals may not experience muscle rippling. While muscle rippling is a characteristic symptom of the disease, not all individuals with Rippling Muscle Disease may exhibit this feature. Additionally, muscle rippling can occur not only during muscle contraction but also with muscle stretching or percussion. There is no age limitation for the occurrence of muscle rippling.Rate this question:
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- 21.
Are there any known associations between Rippling Muscle Disease and malignant hyperthermia susceptibility?
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Yes, individuals with Rippling Muscle Disease are at a higher risk of malignant hyperthermia
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No, there is no association between the two conditions
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Only individuals with coexisting RYR1 mutations are at a higher risk
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Malignant hyperthermia is common but not directly associated with Rippling Muscle Disease
Correct Answer
A. Only individuals with coexisting RYR1 mutations are at a higher riskExplanation
The correct answer is Only individuals with coexisting RYR1 mutations are at a higher risk. There is an association between Rippling Muscle Disease and malignant hyperthermia susceptibility, but it primarily applies to individuals who have coexisting RYR1 mutations. Malignant hyperthermia is a pharmacogenetic disorder triggered by certain drugs and is not common in individuals solely affected by Rippling Muscle Disease.Rate this question:
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- 22.
Does Rippling Muscle Disease affect sensory perception?
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Yes, it commonly causes sensory loss
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No, it does not impact sensory perception
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Sensory perception may be mildly affected
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Only proprioception is affected
Correct Answer
A. Sensory perception may be mildly affectedExplanation
The correct answer is Sensory perception may be mildly affected. Rippling Muscle Disease is primarily a muscle disorder and does not significantly impact sensory perception. However, in some cases, mild sensory abnormalities or changes in sensitivity to touch and vibration may be observed. It does not commonly lead to sensory loss or affect proprioception.Rate this question:
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- 23.
Is Rippling Muscle Disease progressive?
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Yes, it progressively worsens over time
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No, it remains stable without progression
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Progression varies among affected individuals
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Rippling Muscle Disease is always non-progressive
Correct Answer
A. Progression varies among affected individualsExplanation
The correct answer is Progression varies among affected individuals. The progression of Rippling Muscle Disease can vary significantly among individuals. Some individuals experience a relatively stable course without significant progression, while others may have a more progressive course with worsening symptoms over time. The rate and severity of progression can differ, even within the same family affected by the disease.Rate this question:
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- 24.
Are there any known neurologic symptoms associated with Rippling Muscle Disease?
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Yes, it commonly presents with neurologic symptoms
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No, there are no neurologic symptoms
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Neurologic symptoms are only seen in children
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Neurologic symptoms are rare but can occur in some cases
Correct Answer
A. Neurologic symptoms are rare but can occur in some casesExplanation
The correct answer is Neurologic symptoms are rare but can occur in some cases. While Rippling Muscle Disease primarily affects muscles, it can also be accompanied by neurologic symptoms in some cases. These symptoms may include mild myotonic-like features, hyperexcitability of nerves, or muscle cramps. However, such neurologic symptoms are not commonly seen and may vary among affected individuals.Rate this question:
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- 25.
What is the approximate prevalence of Rippling Muscle Disease?
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1 in 100,000 individuals
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1 in 250,000 individuals
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1 in 500,000 individuals
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1 in 1,000,000 individuals
Correct Answer
A. 1 in 100,000 individualsExplanation
The correct answer is 1 in 100,000 individuals. Rippling Muscle Disease is a rare disorder, and its prevalence is estimated to be approximately 1 in 100,000 individuals. However, it is important to note that these prevalence figures may vary among different populations and regions.Rate this question:
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Current Version
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Oct 03, 2023Quiz Edited by
ProProfs Editorial Team -
Jul 04, 2023Quiz Created by
Amit Mangal
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