1.
AMD occurs when _______ accumulates in the retina and eventually causes macular degeneration. This combination of _______ accumulation and atrophy can be referred to as __________
Correct Answer
A. Lipofuscin, Lipofuscin, Brown AtropHy
Explanation
The mixture of lipofuscin accumulation and atrophy of an organ can be referred to as brown atrophy. (Slide 64)
2.
Which of the following is the most common cause of cell injury?
Correct Answer
B. Hypoxia
Explanation
Hypoxia is the most common cause of cell injury because it refers to a lack of oxygen supply to the cells. Without sufficient oxygen, cells are unable to carry out their normal functions and can become damaged or die. Hypoxia can occur due to various reasons such as reduced blood flow, respiratory diseases, or high altitudes. It is a common cause of cell injury in various organs and tissues, leading to cellular dysfunction and potentially organ failure.
3.
Necrosis which occurred secondary to vascular occlusion and affected lower extremities would most likely be called
Correct Answer
A. Gangrenous necrosis
Explanation
Gangrenous necrosis is the most likely term to describe necrosis that occurs as a result of vascular occlusion and affects the lower extremities. Gangrenous necrosis refers to the death of tissue due to a lack of blood supply, typically caused by blockage or damage to blood vessels. This condition often leads to tissue decay, discoloration, and a foul odor. Given that the necrosis is occurring in the lower extremities and is a consequence of vascular occlusion, gangrenous necrosis is the most appropriate term to describe the condition.
4.
A decrease in ATP will have which of the following cellular effects? (select 2)
Correct Answer(s)
A. Decrease in pH (due to increased lactate production)
C. Influx of calcium
Explanation
There will be an influx of calcium and sodium due to the breakdown of the ATP pumps. This means that potassium will efflux more (potassium has a tendency to exit the cell)
5.
Which of the following is not a sign of irreversible cell injury?
Correct Answer
C. Pigment accumulation (lipofuscin, hemosiderin, melanin, ...)
Explanation
Pigment accumulation (lipofuscin, hemosiderin, melanin, ...) is not a sign of irreversible cell injury. Pigments such as lipofuscin, hemosiderin, and melanin can accumulate in cells as a result of normal aging or certain pathological conditions, but their presence alone does not indicate irreversible damage to the cell. On the other hand, severe membrane damage, lysosomal rupture, pyknosis (shrinkage and increased basophilia of the nucleus), and karyolysis (dissolution of the nucleus) are all characteristic features of irreversible cell injury.
6.
Adaptive cell responses such as aplasia and atrophy are potentially reversible processes.
Correct Answer
A. True
Explanation
Adaptive cell responses like aplasia (the failure of an organ or tissue to develop or to function normally) and atrophy (the decrease in size and function of a cell, tissue, or organ) are indeed potentially reversible processes. These changes occur in response to alterations in the environment, such as decreased workload, loss of innervation, diminished blood supply, or inadequate nutrition, and can often be reversed if the underlying condition is corrected.
7.
After an ischemic injury, which of the following will survive the longest without irreversible cell damage?
Correct Answer
A. Bicep muscle cells
Explanation
Skeletal muscle can last for hours after an ischemic injury. Neurons have the shortest lifetime.
8.
If tumor suppressor p53 was deactivated, which of the following would be expected to occur
Correct Answer
A. Decreased apoptosis of cells
Explanation
p53 controls apoptosis, without this tumor suppressor protein inducing apoptosis, there would be less programmed cell death occurring.
9.
Intradermal nevi fall into which category?
Correct Answer
B. Dysplasia
Explanation
Intradermal nevi fall into the category of dysplasia. Dysplasia refers to the abnormal development or growth of cells or tissues. Intradermal nevi are benign skin growths that occur in the dermis layer of the skin. They are characterized by the presence of disorganized and abnormal cells, which is a hallmark of dysplasia.