How Much Do You Know About Antidyslipidemic?
Dyslipidemia is the increase in amounts of lipids or fat within the body. This situation increases the chance of clogged arteries and therefore, many circulatory concerns such as stroke. There are some drugs given out for patients to curb this. How much do you know about Antidyslipidemic? Well take up the short quiz below and get to find out for sure.
- 1.
In patients with combine hyperlipidemia. Which of the following drugs is most likely to increase this patient’s triglyceride and VLDL cholesterol concentrations when used as monotherapy?
- A.
Atorvastatin
- B.
Cholestyramine
- C.
Ezetimibe
- D.
Gemfibrozil
Correct Answer
B. CholestyramineExplanation
Cholestyramine is a bile acid sequestrant that works by binding to bile acids in the intestines, preventing their reabsorption and promoting their excretion. This leads to increased clearance of cholesterol from the body, which in turn stimulates the liver to produce more cholesterol. However, cholestyramine can also increase triglyceride and VLDL cholesterol concentrations, particularly in patients with combined hyperlipidemia, which is characterized by elevated levels of both LDL cholesterol and triglycerides. Therefore, when used as monotherapy, cholestyramine is most likely to increase this patient's triglyceride and VLDL cholesterol concentrations.Rate this question:
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- 2.
Which of the following is a major mechanism of gemfibrozil’s action?
- A.
Increased excretion of bile acid salts
- B.
Increased expression of high-affinity LDL receptors
- C.
Increased secretion of VLDL by the liver
- D.
Increased triglyceride hydrolysis by lipoprotein lipase
Correct Answer
D. Increased triglyceride hydrolysis by lipoprotein lipaseExplanation
Gemfibrozil is a medication used to lower triglyceride levels in the blood. It works by increasing the activity of lipoprotein lipase, an enzyme that breaks down triglycerides. This leads to increased triglyceride hydrolysis, resulting in lower levels of triglycerides in the blood. Therefore, the correct answer is "Increased triglyceride hydrolysis by lipoprotein lipase."Rate this question:
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- 3.
Which of the following is a major toxicity associated with gemfibrozil therapy?
- A.
Bloating and constipation
- B.
Cholelithiasis "gall stones"
- C.
Hyperuricemia
- D.
Liver damage
Correct Answer
B. Cholelithiasis "gall stones"Explanation
Cholelithiasis, or the formation of gallstones, is a major toxicity associated with gemfibrozil therapy. Gemfibrozil is a medication commonly used to lower cholesterol and triglyceride levels in the blood. However, one of its side effects is an increased risk of gallstone formation. Gallstones are solid deposits that form in the gallbladder and can cause symptoms such as abdominal pain, bloating, and indigestion. Therefore, cholelithiasis is a significant concern when considering the use of gemfibrozil as a therapeutic option.Rate this question:
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- 4.
In a patient with dyslipidemia and has a history of gout, which of the following drugs is most likely to exacerbate this condition?
- A.
Colestipol
- B.
Ezetimibe
- C.
Gemfibrozil
- D.
Niacin
Correct Answer
D. NiacinExplanation
Niacin is most likely to exacerbate gout in a patient with dyslipidemia. Niacin is known to increase uric acid levels in the body, which can lead to gout attacks. Gout is a form of arthritis caused by the buildup of uric acid crystals in the joints. Therefore, prescribing niacin to a patient with a history of gout and dyslipidemia may worsen their gout symptoms.Rate this question:
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- 5.
While treating dyslipidemia, after being counseled about lifestyle and dietary changes, the patient was started on atorvastatin. During his treatment with atorvastatin, it is important to routinely monitor serum concentrations of which of the following?
- A.
Blood urea
- B.
Alanine and aspartate aminotransferase
- C.
Platelets
- D.
Red blood cells
Correct Answer
B. Alanine and aspartate aminotransferaseExplanation
During treatment with atorvastatin, it is important to routinely monitor serum concentrations of alanine and aspartate aminotransferase. Atorvastatin is a statin medication used to treat dyslipidemia by reducing cholesterol levels. However, statins can cause liver damage, and monitoring liver function tests, such as alanine and aspartate aminotransferase levels, is necessary to detect any potential liver toxicity. Monitoring blood urea, platelets, and red blood cells is not specifically required during atorvastatin treatment.Rate this question:
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- 6.
Six months after beginning atorvastatin, a patient’s total and LDL cholesterol concentrations remained above normal, his physician decided to add ezetimibe. Which of the following is the most accurate description of ezetimibe’s mechanism of an action?
- A.
Decreased lipid synthesis in adipose tissue
- B.
Decreased secretion of VLDL by the liver
- C.
Decreased gastrointestinal absorption of cholesterol
- D.
Increased endocytosis of HDL by the liver
Correct Answer
C. Decreased gastrointestinal absorption of cholesterolExplanation
Ezetimibe works by decreasing the absorption of cholesterol in the gastrointestinal tract. This means that less cholesterol is able to be absorbed into the bloodstream from the food that is consumed. By reducing the amount of cholesterol that is absorbed, ezetimibe helps to lower total and LDL cholesterol concentrations in the body. This can be especially beneficial for patients who have high cholesterol levels that are not adequately controlled by other medications, such as atorvastatin.Rate this question:
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Current Version
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Mar 21, 2023Quiz Edited by
ProProfs Editorial Team -
Mar 27, 2018Quiz Created by
DrHAboshousha
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