Anti-Arrhythmic MCQ

1. What is an arrhythmia?

Accelerated heart beat.

Slow heart beat.

Irregular heart beat.

A type of heart cancer

An arrhythmia refers to an irregular heart beat, where the heart beats too fast, too slow, or in an irregular pattern. It is a condition that disrupts the normal electrical impulses in the heart, causing it to beat irregularly. This can lead to symptoms such as palpitations, dizziness, and shortness of breath. Arrhythmias can range from harmless to life-threatening, and may require medical intervention depending on their severity and impact on overall health.

Explanation

An arrhythmia refers to an irregular heart beat, where the heart beats too fast, too slow, or in an irregular pattern. It is a condition that disrupts the normal electrical impulses in the heart, causing it to beat irregularly. This can lead to symptoms such as palpitations, dizziness, and shortness of breath. Arrhythmias can range from harmless to life-threatening, and may require medical intervention depending on their severity and impact on overall health.

2. Flecainide has its greatest effect on cardaic function via ________ ______ & the __________ ___ ____.

Purking fibres, bundle of his

Purking fibres, medial temporal bundle

Oxidative stress, bundle of his

Parking fibres , bundle of her

Flecainide has its greatest effect on cardiac function via the purking fibers and the bundle of his. The purking fibers are responsible for transmitting electrical signals to the ventricles, while the bundle of his is responsible for coordinating the contraction of the ventricles. Flecainide likely affects these structures to regulate the electrical activity and contraction of the heart, thereby impacting cardiac function.

Explanation

Flecainide has its greatest effect on cardiac function via the purking fibers and the bundle of his. The purking fibers are responsible for transmitting electrical signals to the ventricles, while the bundle of his is responsible for coordinating the contraction of the ventricles. Flecainide likely affects these structures to regulate the electrical activity and contraction of the heart, thereby impacting cardiac function.

3. Under which class of anti-arrhythmic agents is Flecainide catagorised?

Class I

Class II

Class III

Class IV

Flecainide is categorized under Class I anti-arrhythmic agents. Class I anti-arrhythmics are sodium channel blockers that work by inhibiting the fast inward sodium current during phase 0 of the cardiac action potential. Flecainide specifically belongs to subclass IC, which has a strong sodium channel blocking effect and is used to treat various types of arrhythmias, including ventricular tachycardia and atrial fibrillation/flutter.

Explanation

Flecainide is categorized under Class I anti-arrhythmic agents. Class I anti-arrhythmics are sodium channel blockers that work by inhibiting the fast inward sodium current during phase 0 of the cardiac action potential. Flecainide specifically belongs to subclass IC, which has a strong sodium channel blocking effect and is used to treat various types of arrhythmias, including ventricular tachycardia and atrial fibrillation/flutter.

4. How do anti-arrhythmic agents work?

They change electrical conduction of the heart by targeting the defective myocytes.

They change electrical conduction of the heart by targeting the pacemaker.

They change electrical conduction of the heart by targeting the ion channels

They change electrical conduction of the vasculature by targeting the ion channels

Anti-arrhythmic agents work by targeting the ion channels in the heart, which are responsible for the electrical conduction. By modifying the activity of these ion channels, these medications can help regulate and stabilize the heart's electrical rhythm, treating arrhythmias.

Explanation

Anti-arrhythmic agents work by targeting the ion channels in the heart, which are responsible for the electrical conduction. By modifying the activity of these ion channels, these medications can help regulate and stabilize the heart's electrical rhythm, treating arrhythmias.

5. Anti-arrhythmic agents are divided into 5 classes, match each class with its mechanism.

Class I

Class II

Class III

Class IV

Class V

Submit

6. What is proarrhthmia?

A worsening of existing arrhythmias

A development of new arrhythmias

A development of new arrhythmias and/or a worsening of existing arrhythmias

The development of new myocytes

Proarrhythmia refers to the development of new arrhythmias and/or a worsening of existing arrhythmias. This means that it can involve the occurrence of new abnormal heart rhythms or the deterioration of already existing abnormal heart rhythms. It is important to monitor and manage proarrhythmia as it can have serious implications for the heart's functioning and overall health.

Explanation

Proarrhythmia refers to the development of new arrhythmias and/or a worsening of existing arrhythmias. This means that it can involve the occurrence of new abnormal heart rhythms or the deterioration of already existing abnormal heart rhythms. It is important to monitor and manage proarrhythmia as it can have serious implications for the heart's functioning and overall health.

7. Flecainide has no effect on re-polarization. True or false?

True

False

Flecainide is a medication used to treat certain types of irregular heart rhythms. It works by blocking certain electrical signals in the heart, which helps to regulate the heart's rhythm. However, it does not have any direct effect on the process of repolarization, which is the phase of the heart's electrical cycle where the heart muscle cells relax and prepare for the next contraction. Therefore, the statement that "Flecainide has no effect on repolarization" is true.

Explanation

Flecainide is a medication used to treat certain types of irregular heart rhythms. It works by blocking certain electrical signals in the heart, which helps to regulate the heart's rhythm. However, it does not have any direct effect on the process of repolarization, which is the phase of the heart's electrical cycle where the heart muscle cells relax and prepare for the next contraction. Therefore, the statement that "Flecainide has no effect on repolarization" is true.

8. Proarrthmias are most common in which 2 classes of anti-arrhythmic agents?

Class II & Class IV

Class I & Class III

Class III & Class V

Class I & Class V

Proarrhythmias, or the development of new or worsening arrhythmias, are most commonly associated with the use of Class I and Class III antiarrhythmic agents. Class I agents work by blocking sodium channels and slowing down conduction in the heart, while Class III agents prolong the action potential duration by blocking potassium channels. Both of these classes of drugs have the potential to disrupt the normal electrical activity of the heart and lead to proarrhythmias.

Explanation

Proarrhythmias, or the development of new or worsening arrhythmias, are most commonly associated with the use of Class I and Class III antiarrhythmic agents. Class I agents work by blocking sodium channels and slowing down conduction in the heart, while Class III agents prolong the action potential duration by blocking potassium channels. Both of these classes of drugs have the potential to disrupt the normal electrical activity of the heart and lead to proarrhythmias.

9. Flecainide_________________________.

Increases conduction velocity.

Decreases conduction velocity

Has no affect on conduction velocity.

Can increase/decrease conduction velocity depending on concentration

Flecainide is a class I antiarrhythmic medication that works by blocking sodium channels in the heart. By doing so, it slows down the conduction of electrical impulses through the heart, leading to a decrease in conduction velocity. This can be beneficial in certain arrhythmias where there is rapid conduction of electrical impulses, as it helps to normalize the heart rhythm. Therefore, the correct answer is that flecainide decreases conduction velocity.

Explanation

Flecainide is a class I antiarrhythmic medication that works by blocking sodium channels in the heart. By doing so, it slows down the conduction of electrical impulses through the heart, leading to a decrease in conduction velocity. This can be beneficial in certain arrhythmias where there is rapid conduction of electrical impulses, as it helps to normalize the heart rhythm. Therefore, the correct answer is that flecainide decreases conduction velocity.

10. What is the most common side effect of anti-arrhythmic therapy?

Pseudo arrhythmia

Proarrhythmia

Bradycardia.

Tachycardia

Proarrhythmia is the most common side effect of anti-arrhythmic therapy. Proarrhythmia refers to the development of new or worsening arrhythmias as a result of the medication. This can occur due to the drug's direct effects on cardiac electrical conduction or due to its proarrhythmic properties. It is important to monitor patients closely for any signs of proarrhythmia while on anti-arrhythmic therapy to ensure prompt management and prevention of potentially life-threatening arrhythmias.

Explanation

Proarrhythmia is the most common side effect of anti-arrhythmic therapy. Proarrhythmia refers to the development of new or worsening arrhythmias as a result of the medication. This can occur due to the drug's direct effects on cardiac electrical conduction or due to its proarrhythmic properties. It is important to monitor patients closely for any signs of proarrhythmia while on anti-arrhythmic therapy to ensure prompt management and prevention of potentially life-threatening arrhythmias.

11. The toxicity of flecainide is linnked to what?

Age of patient.

Type of arrhythmia.

Whether the patient is being treated at home or in hospital.

Plasma concentration.

The toxicity of flecainide is linked to the plasma concentration. This means that higher levels of flecainide in the bloodstream can lead to toxic effects. It is important to monitor the plasma concentration of flecainide in patients to ensure that it remains within a safe range.

Explanation

The toxicity of flecainide is linked to the plasma concentration. This means that higher levels of flecainide in the bloodstream can lead to toxic effects. It is important to monitor the plasma concentration of flecainide in patients to ensure that it remains within a safe range.