1.
What is an arrhythmia?
Correct Answer
C. Irregular heart beat.
Explanation
An arrhythmia refers to an irregular heart beat, where the heart beats too fast, too slow, or in an irregular pattern. It is a condition that disrupts the normal electrical impulses in the heart, causing it to beat irregularly. This can lead to symptoms such as palpitations, dizziness, and shortness of breath. Arrhythmias can range from harmless to life-threatening, and may require medical intervention depending on their severity and impact on overall health.
2.
How do anti-arrhythmic agents work?
Correct Answer
C. They change electrical conduction of the heart by targeting the ion channels
Explanation
Anti-arrhythmic agents work by targeting the ion channels in the heart, which are responsible for the electrical conduction. By modifying the activity of these ion channels, these medications can help regulate and stabilize the heart's electrical rhythm, treating arrhythmias.
3.
What is the most common side effect of anti-arrhythmic therapy?
Correct Answer
B. Proarrhythmia
Explanation
Proarrhythmia is the most common side effect of anti-arrhythmic therapy. Proarrhythmia refers to the development of new or worsening arrhythmias as a result of the medication. This can occur due to the drug's direct effects on cardiac electrical conduction or due to its proarrhythmic properties. It is important to monitor patients closely for any signs of proarrhythmia while on anti-arrhythmic therapy to ensure prompt management and prevention of potentially life-threatening arrhythmias.
4.
What is proarrhthmia?
Correct Answer
C. A development of new arrhythmias and/or a worsening of existing arrhythmias
Explanation
Proarrhythmia refers to the development of new arrhythmias and/or a worsening of existing arrhythmias. This means that it can involve the occurrence of new abnormal heart rhythms or the deterioration of already existing abnormal heart rhythms. It is important to monitor and manage proarrhythmia as it can have serious implications for the heart's functioning and overall health.
5.
Proarrthmias are most common in which 2 classes of anti-arrhythmic agents?
Correct Answer
B. Class I & Class III
Explanation
Proarrhythmias, or the development of new or worsening arrhythmias, are most commonly associated with the use of Class I and Class III antiarrhythmic agents. Class I agents work by blocking sodium channels and slowing down conduction in the heart, while Class III agents prolong the action potential duration by blocking potassium channels. Both of these classes of drugs have the potential to disrupt the normal electrical activity of the heart and lead to proarrhythmias.
6.
Under which class of anti-arrhythmic agents is Flecainide catagorised?
Correct Answer
A. Class I
Explanation
Flecainide is categorized under Class I anti-arrhythmic agents. Class I anti-arrhythmics are sodium channel blockers that work by inhibiting the fast inward sodium current during phase 0 of the cardiac action potential. Flecainide specifically belongs to subclass IC, which has a strong sodium channel blocking effect and is used to treat various types of arrhythmias, including ventricular tachycardia and atrial fibrillation/flutter.
7.
Flecainide_________________________.
Correct Answer
B. Decreases conduction velocity
Explanation
Flecainide is a class I antiarrhythmic medication that works by blocking sodium channels in the heart. By doing so, it slows down the conduction of electrical impulses through the heart, leading to a decrease in conduction velocity. This can be beneficial in certain arrhythmias where there is rapid conduction of electrical impulses, as it helps to normalize the heart rhythm. Therefore, the correct answer is that flecainide decreases conduction velocity.
8.
Flecainide has its greatest effect on cardaic function via ________ ______ & the __________ ___ ____.
Correct Answer
A. Purking fibres, bundle of his
Explanation
Flecainide has its greatest effect on cardiac function via the purking fibers and the bundle of his. The purking fibers are responsible for transmitting electrical signals to the ventricles, while the bundle of his is responsible for coordinating the contraction of the ventricles. Flecainide likely affects these structures to regulate the electrical activity and contraction of the heart, thereby impacting cardiac function.
9.
Flecainide has no effect on re-polarization. True or false?
Correct Answer
A. True
Explanation
Flecainide is a medication used to treat certain types of irregular heart rhythms. It works by blocking certain electrical signals in the heart, which helps to regulate the heart's rhythm. However, it does not have any direct effect on the process of repolarization, which is the phase of the heart's electrical cycle where the heart muscle cells relax and prepare for the next contraction. Therefore, the statement that "Flecainide has no effect on repolarization" is true.
10.
The toxicity of flecainide is linnked to what?
Correct Answer
D. Plasma concentration.
Explanation
The toxicity of flecainide is linked to the plasma concentration. This means that higher levels of flecainide in the bloodstream can lead to toxic effects. It is important to monitor the plasma concentration of flecainide in patients to ensure that it remains within a safe range.
11.
What does the treatent of flecainide toxicity involve? (Choose 3)
Correct Answer(s)
A. Increasing the Na concentration at the active site
E. Prescription of pHysostigmine
F. Decrease/removal of dose