Azithromycin is recommended as an option for first-line treatment
Doxycycline or a respiratory fluoroquinolone should be instituted in most uncomplicated cases
Fidaxomicin is now indicated as a primary treatment option
Antibiotic use is frequently ineffective, given that most cases are viral
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Temperature >101.1°F (38.39°C)
Facial pain lasting 3 days or longer
Worsening symptoms after an illness lasting 5 days had begun improving
Persistent symptoms lasting longer than 10 days
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Colored sputum indicates bacterial infection necessitating antibiotic treatment
Longer cough duration suggests a need for antibiotic treatment
Suspicion of pneumonia is the primary indication to initiate antibiotic treatment
Routine chest x-ray is indicated in all cases to determine the need for antibiotic treatment
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Antihistamines and nasal saline irrigation are proven treatments for cold symptom relief
NSAIDs are contraindicated if antibiotic treatment is initiated
A change in nasal discharge color is an indication for antibiotic initiation
Educate patients that symptoms may last as long as 2 weeks and do not initiate antibiotics
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First-line treatment includes azithromycin and clindamycin
Initiation of antibiotic treatment prior to the results of a rapid antigen detection test is recommended in symptomatic patients
Penicillin V remains a first-line therapy due to its reliable antibiotic activity against group A beta-hemolytic streptococcal (GAS) infection
Severe, persistent sore throat alone is an indication for antibiotic therapy
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