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What is the mechanism of action of benzodiazepines?
A.
Increase affinity of GABA receptor for GABA, increasing channel opening, increasing Cl- influx into cell, causing hyperpolarisation, decreasing the excitability of neurons
B.
Increase affinity of GABA receptor for bdzs, increasing channel opening, increasing Cl- influx into cell, causing depolarisation, decreasing excitability of neurons
C.
Increase affinity of GABA receptor for GABA, increasing channel opening, increasing Cl- influx into cell, causing rapid repolarisation, increasing the excitability of neurons
Correct Answer
A. Increase affinity of GABA receptor for GABA, increasing channel opening, increasing Cl- influx into cell, causing hyperpolarisation, decreasing the excitability of neurons
Explanation Benzodiazepines increase the affinity of the GABA receptor for GABA, which in turn increases the opening of the channel. This leads to an increased influx of chloride ions (Cl-) into the cell, causing hyperpolarization. Hyperpolarization decreases the excitability of neurons, making them less likely to fire action potentials. Therefore, the mechanism of action of benzodiazepines is to enhance the inhibitory effects of GABA on neuronal activity, resulting in a calming and sedative effect.
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2.
What are the effects of benzodiazepines?
A.
Reduction of anxiety/aggression; increased drowsiness; reduction of muscle tone; anticonvulsant
B.
Reduction of anxiety but not aggression; sedation and induction of sleep; increased muscle tone; anticonvulsant
C.
Reduction of anxiety/aggression; sedation and induction of sleep; reduction of muscle tone; anticonvulsant
Correct Answer
C. Reduction of anxiety/aggression; sedation and induction of sleep; reduction of muscle tone; anticonvulsant
Explanation Benzodiazepines have multiple effects on the body. They are known to reduce anxiety and aggression, providing a calming effect. They also induce sedation and sleep, making them useful for treating insomnia. Benzodiazepines can reduce muscle tone, making them effective for muscle relaxation and treating muscle spasms. Additionally, they have anticonvulsant properties, meaning they can help prevent and control seizures.
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3.
Which of the following are examples of short and long-acting bdzs?
A.
Short - nordiazepam; long - oxazepam
B.
Short - temazepam; long - nordiazepam
C.
Short - oxazepam; long - nordiazepam
Correct Answer
B. Short - temazepam; long - nordiazepam
Explanation Temazepam is classified as a short-acting benzodiazepine (BZD) because it has a relatively short duration of action and is commonly used for the treatment of insomnia. On the other hand, nordiazepam is classified as a long-acting BZD because it has a longer duration of action and is often used in the management of anxiety disorders. Therefore, the given answer correctly identifies temazepam as a short-acting BZD and nordiazepam as a long-acting BZD.
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4.
Which of the following is a bdzs antagonist and what is its purpose?
A.
Flumazenizenil; reverses effects of bdzs in case of poisoning
B.
Zolpidem; reverses effects of bdzs in cause of adverse effects
C.
Amitriptyline; prolongs effects of bdzs
Correct Answer
A. Flumazenizenil; reverses effects of bdzs in case of poisoning
Explanation Flumazenil is a benzodiazepine antagonist that is used to reverse the effects of benzodiazepines in cases of poisoning. When someone has overdosed on benzodiazepines, Flumazenil can be administered to block the receptors that benzodiazepines bind to, effectively reversing their effects. This can help to restore normal consciousness and respiratory function in individuals who have been affected by benzodiazepine overdose.
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5.
Which of the following are examples of 5-HT agonists?
A.
Buspirone; tandospirone
B.
Citalopram; zolpidem
C.
Quinidine; lidocaine
Correct Answer
A. Buspirone; tandospirone
Explanation Buspirone and tandospirone are examples of 5-HT agonists. 5-HT agonists are drugs that stimulate the 5-HT receptors in the brain, which are involved in regulating mood, anxiety, and other functions. Buspirone and tandospirone are both used as anxiolytic medications, meaning they help to reduce anxiety. They work by increasing the activity of serotonin (5-HT) in the brain, which can have a calming and mood-stabilizing effect. Citalopram and zolpidem are not 5-HT agonists, they are selective serotonin reuptake inhibitors (SSRIs) and a sedative-hypnotic respectively. Quinidine and lidocaine are not 5-HT agonists either, they are antiarrhythmic medications.
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6.
B-blockers mainly target...
A.
Sleep disturbance; aggression
B.
Sweating; tremor; tachycardia
C.
Apprehension; dread
Correct Answer
B. Sweating; tremor; tachycardia
Explanation B-blockers mainly target sweating, tremor, and tachycardia. B-blockers, also known as beta-blockers, are a class of medications that primarily block the effects of adrenaline on the beta receptors in the body. By blocking these receptors, B-blockers can reduce the symptoms associated with excessive sympathetic nervous system activity, such as sweating, tremor, and tachycardia (rapid heart rate). These medications are commonly used to treat conditions like hypertension, angina, and certain cardiac arrhythmias.
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