1.
After a typical high carbohydrate meal, the pancreas is stimulated to release ____.
Explanation
After consuming a meal that is high in carbohydrates, the body's blood sugar levels increase. In response to this, the pancreas is stimulated to release insulin. Insulin helps regulate blood sugar levels by allowing glucose to enter cells and be used for energy. This hormone also helps store excess glucose in the liver for later use. Therefore, the release of insulin after a high carbohydrate meal is necessary to maintain stable blood sugar levels and prevent them from becoming too high.
2.
The ____ is the first tissue to have the opportunity to use dietary glucose.
Explanation
The liver is the first tissue to have the opportunity to use dietary glucose because it plays a crucial role in regulating blood glucose levels. When we consume food, the liver absorbs glucose from the bloodstream and stores it as glycogen for later use. It also has the ability to convert excess glucose into fatty acids for long-term energy storage. Additionally, the liver can release stored glucose back into the bloodstream when blood sugar levels drop, ensuring a steady supply of energy for the body.
3.
____ ________, which catalyzes the first step in gluconeogenesis is inactive due to low levels of acetyl CoA.
Explanation
Pyruvate carboxylase is inactive due to low levels of acetyl CoA. Acetyl CoA is an important cofactor that activates pyruvate carboxylase, allowing it to catalyze the first step in gluconeogenesis. Without sufficient levels of acetyl CoA, pyruvate carboxylase cannot function properly, leading to the inhibition of gluconeogenesis.
4.
Long-term effects: insulin induces the synthesis of _____ and pyruvate kinase.
Explanation
Insulin induces the synthesis of glucokinase and pyruvate kinase. Glucokinase is an enzyme that helps in the phosphorylation of glucose to glucose-6-phosphate in the liver, allowing for the storage of glucose as glycogen. Pyruvate kinase is an enzyme involved in the final step of glycolysis, where it catalyzes the conversion of phosphoenolpyruvate (PEP) to pyruvate, generating ATP. Therefore, insulin's long-term effects include increasing the synthesis of these enzymes, which play important roles in glucose metabolism and energy production.
5.
The ____ cycle is interrupted in the well-fed state.
Explanation
In the well-fed state, the Krebs cycle is interrupted. The Krebs cycle, also known as the citric acid cycle, is responsible for the oxidation of acetyl-CoA, producing energy in the form of ATP, NADH, and FADH2. However, in the well-fed state, there is an abundance of nutrients available, particularly glucose. This excess glucose is converted into glycogen through a process called glycogenesis, which occurs in the Cori cycle. Therefore, the Krebs cycle is interrupted as the body prioritizes the storage of excess glucose as glycogen in the liver and muscles.
6.
Acetyl CoA is used for fatty acid synthesis and ____ synthesis. Both synthetic pathways are activated by insulin.
Explanation
Acetyl CoA is used for fatty acid synthesis and cholesterol synthesis. Both synthetic pathways are activated by insulin. This means that when insulin levels are high, such as after a meal, the body promotes the synthesis of fatty acids and cholesterol. Acetyl CoA is a key molecule in these processes, serving as a building block for the production of both fatty acids and cholesterol. Therefore, the correct answer is cholesterol.
7.
The high ______ ratio increases the concentration of fructose 2,6-bisphosphate to ____ glycolysis in the well-fed state.
Correct Answer
C. Insulin/glucagon, activate
Explanation
In the well-fed state, the high insulin/glucagon ratio increases the concentration of fructose 2,6-bisphosphate, which in turn activates glycolysis. Insulin promotes the synthesis of fructose 2,6-bisphosphate, while glucagon inhibits its synthesis. Therefore, the high insulin levels and low glucagon levels in the well-fed state favor the activation of glycolysis through increased fructose 2,6-bisphosphate concentration.
8.
Elevated insulin levels lead to _____ and therefore ______ of hormone-sensitive lipase.
Correct Answer
D. Dephosphorylation / inactivation
Explanation
Elevated insulin levels lead to dephosphorylation of hormone-sensitive lipase, resulting in its inactivation. Insulin is a hormone released by the pancreas in response to high blood glucose levels. It promotes the uptake and storage of glucose in cells, inhibiting the breakdown of stored fats. Dephosphorylation refers to the removal of phosphate groups from a molecule, which can alter its activity. In this case, dephosphorylation of hormone-sensitive lipase decreases its activity, preventing the release of stored fats.
9.
In the well-fed state, ___ is the primary source of energy for muscle.
Correct Answer
glucose
Explanation
In the well-fed state, glucose is the primary source of energy for muscles. Glucose is a type of sugar that is obtained from the breakdown of carbohydrates in the diet. It is transported through the bloodstream to the muscles where it is converted into ATP, the energy currency of cells. This process, known as glycolysis, allows muscles to contract and perform their functions. Other sources of energy, such as fats and proteins, can also be used by muscles, but glucose is preferred due to its efficiency and quick availability.
10.
Except in conditions of starvation, ____ is the only fuel for the brain.
Correct Answer
glucose
Explanation
Glucose is the primary source of energy for the brain, except in cases of extreme starvation when the body resorts to using alternative fuel sources. The brain relies on glucose to function optimally as it is unable to store or produce its own glucose. This is because glucose is easily transported across the blood-brain barrier and can be readily metabolized by brain cells to produce ATP, the energy currency of cells. Therefore, glucose is essential for maintaining normal brain function and cognitive processes.
11.
Red blood cells can use only glucose as fuel because they lack _________
Correct Answer
mitochondria
Explanation
Red blood cells lack mitochondria, which are responsible for producing ATP (Adenosine Triphosphate) through cellular respiration. Without mitochondria, red blood cells are unable to generate energy through the breakdown of glucose, which is the primary fuel source for most cells. Therefore, red blood cells rely solely on anaerobic glycolysis to produce ATP, which is less efficient compared to aerobic respiration.
12.
During fasting, the liver converts fatty acids into ___ ____ which are released into the blood.
Correct Answer
ketone bodies
Explanation
During fasting, the body's primary source of energy shifts from glucose to stored fats. The liver plays a crucial role in this process by converting fatty acids into ketone bodies, which are then released into the bloodstream. Ketone bodies, such as acetoacetate, beta-hydroxybutyrate, and acetone, can be used as an alternative energy source by various tissues, including the brain, during periods of low glucose availability. This metabolic adaptation helps to preserve glucose for essential functions and ensures a continuous supply of energy for the body.
13.
Stored fuels suffice for caloric needs for 3 months, but _____ reserves are gone in one day.
Correct Answer
carbohydrate
Explanation
Stored fuels, such as fats and proteins, can provide enough calories to sustain the body's needs for up to 3 months. However, carbohydrate reserves, which are stored in the form of glycogen in the liver and muscles, can be depleted in just one day. Carbohydrates are the body's primary source of energy and are quickly broken down to provide fuel for various bodily functions. Once the glycogen stores are used up, the body needs to rely on other sources of energy, such as fats, to meet its caloric needs.
14.
____ plays an essential role in maintaining blood glucose levels during overnight and prolonged fasting.
Correct Answer
gluconeogenesis
Explanation
Gluconeogenesis is the process by which the body produces glucose from non-carbohydrate sources, such as amino acids and glycerol. During overnight and prolonged fasting, the body needs to maintain blood glucose levels to ensure a steady supply of energy for vital functions. Gluconeogenesis allows the body to produce glucose even when there is no dietary intake of carbohydrates, thus playing an essential role in maintaining blood glucose levels during fasting periods.
15.
In the fasting state, the liver gets energy by oxidizing ___ ___ released from adipose tissue.
Correct Answer
fatty acids
Explanation
In the fasting state, when the body is not receiving food, the liver needs a source of energy to function properly. It obtains this energy by oxidizing fatty acids that are released from adipose tissue. Fatty acids are the primary fuel source for the liver during periods of fasting as they can be broken down and converted into usable energy through a process called beta-oxidation. Therefore, the liver relies on the oxidation of fatty acids to meet its energy demands in the absence of food intake.
16.
In the fasting state, uptake of fatty acids is
Correct Answer
B. Decreased
Explanation
In the fasting state, the body's primary source of energy shifts from glucose to stored fat. This is because insulin levels decrease, leading to a decrease in the uptake of fatty acids by cells. As a result, the uptake of fatty acids is decreased in the fasting state.
17.
In starvation periods longer than two to three weeks, plasma ___ ___ may supply as much as 2/3 of the energy requirements of the brain.
Correct Answer
ketone bodies
Explanation
During periods of starvation longer than two to three weeks, the body undergoes a process called ketosis, where it starts breaking down stored fats to produce ketone bodies. These ketone bodies can then be used as an alternative source of energy, particularly by the brain. In fact, ketone bodies can supply as much as 2/3 of the energy requirements of the brain during prolonged periods of starvation.