1.
PGG2 and PGH2 are associated with what? Select all that apply.
Correct Answer(s)
A. Vasoconstriction
C. Platelet aggregation
E. Pain
2.
Aspirin acetylates what enzyme?
Correct Answer
A. Thromboxane synthetase
3.
What is used for the harvest and storage of platelets in renal dialysis and cardiopulmonary bypass?
Correct Answer
B. Prostacyclins
4.
Which enzyme is inducible?
Correct Answer
B. Cox-2
5.
Which of the following is true regarding COX-3? Select all that apply.
Correct Answer(s)
A. Involved in pain
B. Involved in fever
D. Inhibited by acetaminopHen
6.
PGE2 and PGF2α biosynthesis is greatly increased hours before child birth.
Correct Answer
A. True
7.
How does PGE2 help the stomach? Select all that apply.
Correct Answer(s)
A. Inhibits gastric acid secretion
B. Stimulates secretion of mucous
C. Stimulates secretion of bicarb
8.
This drug is available as a gel or vaginal suppository and is used to increase the frequency and amplitutde of uterine contractions. Its onset is 10 minutes and a side effect is cramping.
Correct Answer
C. Dinoprostone (PGE2)
9.
Which is is involved with platelet aggregation inhibition, vasodilation, and protecting the stomach?
Correct Answer
C. PGE2
10.
Misoprostol is used vaginally in combination with __________ for termination of early pregnancy.
Correct Answer
methotrexate
MTX
METHOTREXATE
Methotrexate
mtx
11.
Which NSAID is the least renal toxic?
Correct Answer
E. Sulindac
12.
Sulindac undergoes in vivo _______ to form the sulfide form, the active drug,
Correct Answer
B. Reduction
13.
Unlike Aspirin, Salsalate does not inhibit thromboxane synthetase (does not acetylate), therefore, it has no effect on platelet function.
Correct Answer
A. True
14.
Piroxicam has less severe GI side effects than meloxicam.
Correct Answer
B. False
Explanation
it's the other way around
15.
Piroxicam undergoes what kind of metabolism?
Correct Answer
B. Hydroxylation of pyridine ring (5')
16.
Which of the following is true regarding Meloxicam? Select all that apply.
Correct Answer(s)
A. It is 10 fold more selective for COX-2 than COX-1
C. It is part of an enolic class of NSAIDs
17.
All NSAIDs can cause CNS effects such as dizziness, anxiety, and headaches. Which of the following NSAIDs may cause severe CNS effects?
Correct Answer
A. Indomethacin
18.
Which of the following is true regarding ASA? Select all that apply.
Correct Answer(s)
A. Potency: COX-1 > COX-2
B. Rapidly hydrolyzed by plasma esterases
D. Prevents colon polyp formation
E. The COOH has a direct corrosive effect in causing ulceration
F. Oral bioavailability is 80 to 100%
G. Short half life
19.
Nabumetone's reduced GI side effects is probably due to its COX-2 selectivity and the fact that it has no acidic functional group.
Correct Answer
A. True
20.
Ketorolac is as effective as the opioids in the short term treatment of moderate to severe postoperative pain.
Correct Answer
A. True
21.
Which of the following is true regarding Ibuprofen? Select all that apply.
Correct Answer(s)
A. Sold as racemate. S-enantiomer is more active in vitro (but R-enantioner covered to S-enantiomer in vivo)
B. Metabolism involves I-bu chain oxidation
C. First member of its class (arylpropionic acids)
D. Better tolerated then ASA or Indomethacin
22.
Which drug is available as an opthalmic solution and topical gel?
Correct Answer
C. Diclofenac
23.
Diflunisal is effective as an antipyretic.
Correct Answer
B. False
24.
NSAIDs _________ gestation.
Correct Answer
B. Prolong
25.
Naproxen's half life is ___ hours.
Correct Answer
B. 13
26.
DMARDs include which of the following? Select all that apply.
Correct Answer(s)
A. Gold compounds
B. Immunosupressants
C. Anticancer agents
D. Antimalarials
27.
PGG2 is converted to PGH2 by which enzyme?
Correct Answer(s)
hydroperoxidase
HYDROPEROXIDASE
Hydroperoxidase
28.
Which is involved in vasoconstriction, platelet aggregation, and bronchoconstriction...
Correct Answer
D. Thromboxanes
29.
TXA2 has a half life of 30 seconds.
Correct Answer
A. True
30.
The aliphatic residue of this molecule is of smaller size and creates a side pocket.
Correct Answer
B. COX-2
31.
Which enzyme is found in platelets?
Correct Answer
A. COX-1
32.
Aspirin's major metabolic pathway occurs when this occurs. Also, what percent of an ASA dose is excreted as salicylic acid?
Correct Answer
E. When glycine complexes with the COOH, 10%
33.
Which of the following is true regarding this NSAID? Select all that apply.
Correct Answer(s)
A. Antipyretic, analgesic, and anti-inflammatory
B. Causes less GI upset than ASA
C. Available as oral liquid
34.
Diclofenac undergoes HYDROXYLATION at which position?
Correct Answer
B. 2
35.
Aspirin can prevent colon cancer by preventing polyp formation.
Correct Answer
A. True
36.
Metabolism of this drug primarily includes...
Correct Answer
C. O-demethylation
37.
Which of the following drugs have no appreciable effect on platelets? Select all that apply.
Correct Answer(s)
A. Diflunisal
B. Salsalate
D. Celebrex
E. Choline salicylate
G. Sodium salicylate
38.
Diflunisal is 4 to 5x more potent than ASA, has neglible antipyretic effects, and has less GI side effects.
Correct Answer
A. True
39.
Diclofenac undergoes extensive ______ metabolism.
Correct Answer
B. Hepatic
40.
Which of the following drugs are pro-drugs? Select all that apply.
Correct Answer(s)
A. Sulindac
C. Nabumetone
41.
Ketorolac was the first parenteral NSAID.
Correct Answer
A. True
42.
Which useful group of NSAIDs is also known as "profens?" They are potent anti-inflammatory drugs because of the addition of a methyl group.
Correct Answer
C. Arylpropionic acid
43.
Metabolism of ibuprofen involves the i-bu chain oxidation.
Correct Answer
A. True
44.
Naproxen is the top NSAID.
Correct Answer
A. True
45.
NSAIDs increase uterine motility.
Correct Answer
B. False
Explanation
inhibit uterine motility
46.
________ increases celecoxib plasma two-fold.
Correct Answer
FLUCONAZOLE
fluconazole
Fluconazole
47.
Celebrex is approved for RA, OA, acute pain, and FAP.
Correct Answer
A. True
48.
Which of the following can safely be taken with methotrexate? Select all that apply.
Correct Answer(s)
B. Celebrex
C. BRMs
49.
Which DMARDs are used in mild cases of RA? Select all that apply.
Correct Answer(s)
A. Hydroxychloroquine
C. Sulfasalazine
50.
NSAIDs have the most rapid onset of action. Between DMARDs and BRMs, which acts more quickly?
Correct Answer
B. BRMs