Nausea And Vomiting Quiz

Approved & Edited by ProProfs Editorial Team

The editorial team at ProProfs Quizzes consists of a select group of subject experts, trivia writers, and quiz masters who have authored over 10,000 quizzes taken by more than 100 million users. This team includes our in-house seasoned quiz moderators and subject matter experts. Our editorial experts, spread across the world, are rigorously trained using our comprehensive guidelines to ensure that you receive the highest quality quizzes.

Learn about Our Editorial Process

| By Ashleynecole

Ashleynecole

Community Contributor

Quizzes Created: 3 | Total Attempts: 2,301

Questions: 52 | Attempts: 1,644 | Updated: Mar 22, 2023

Questions

Settings

Feedback

During the Quiz End of Quiz

Play as

Quiz Flashcard

Create your own Quiz

Questions and Answers

1.

Which 5HT-3 receptor antagonist is used for acute AND delayed N/V?
- A.
  
  Ondansetron
- B.
  
  Palonsetron
- C.
  
  Granisetron
- D.
  
  Dolasetron
Correct Answer
B. Palonsetron

Explanation
Palonsetron is the correct answer because it is a 5HT-3 receptor antagonist that is used for both acute and delayed nausea and vomiting (N/V). It is commonly prescribed to prevent and treat N/V caused by chemotherapy and radiation therapy. Palonsetron works by blocking the action of serotonin, a neurotransmitter that triggers N/V. It has a longer half-life compared to other 5HT-3 receptor antagonists, making it effective in preventing delayed N/V as well.

Rate this question:
2.

Which dose is correct when used in combination with aprepitant?
- A.
  
  Ondansetron 32mg IV
- B.
  
  Dexamethasone 12mg IV
- C.
  
  Dexamethasone 20mg IV
- D.
  
  Palonsetron 0.5mg IV
Correct Answer
B. Dexamethasone 12mg IV

Explanation
Ondansetron 32mg can cause QT prolongation. This is the correct dosing for dexamethasone in combo with any NK1RA.

Rate this question:
3.

Which neurotransmitter does NK1RA (Neurokinin-1 Receptor Antagonist) affect?
- A.
  
  Substance P
- B.
  
  Dopamine
- C.
  
  GABA
- D.
  
  Serotonin
Correct Answer
A. Substance P

Explanation
NK1RAs block binding of Substance P in the CNS and GI to treat N/V.

Rate this question:
4.

Acute N/V occurs within the first...
- A.
  
  24 hours
- B.
  
  6 hours
- C.
  
  48 hours
- D.
  
  12 hours
Correct Answer
A. 24 hours

Explanation
Acute N/V (nausea and vomiting) refers to the sudden onset of these symptoms. The correct answer, 24 hours, suggests that acute N/V typically occurs within the first day after a triggering event or condition. This timeframe aligns with common causes of acute N/V such as food poisoning, viral gastroenteritis, or adverse reactions to medications. It is important to note that this is a general guideline and individual experiences may vary.

Rate this question:
5.

Which drugs cause significant delayed N/V? (select all that apply)
- A.
  
  Carboplatin
- B.
  
  Cyclophosphamide
- C.
  
  Cisplatin
- D.
  
  Doxorubicin
- E.
  
  Vincristine
- F.
  
  Etoposide
Correct Answer(s)
A. Carboplatin
B. CyclopHospHamide
C. Cisplatin

Explanation
Carboplatin, cyclophosphamide, and cisplatin are known to cause significant delayed nausea and vomiting (N/V) as side effects. These drugs are commonly used in chemotherapy treatments for various types of cancer. The delayed onset of N/V can occur several hours to days after the administration of these drugs and can significantly impact the patient's quality of life. Doxorubicin, vincristine, and etoposide, on the other hand, are not typically associated with significant delayed N/V.

Rate this question:
6.

Which NK1RA does NOT inhibit CYP3A4?
- A.
  
  Rolapitant
- B.
  
  Netupitant
- C.
  
  Aprepitant
- D.
  
  All inhibit CYP3A4
Correct Answer
A. Rolapitant

Explanation
This drug also has a long half life (180 hours)!

Rate this question:
7.

Which drug causes severe extravasation reactions?
- A.
  
  Promethazine
- B.
  
  Metoclopramide
- C.
  
  Aprepitant
- D.
  
  Haloperidol
Correct Answer
A. Promethazine

Explanation
Must dilute with 10mL NS if giving IV. Try to use oral if possible.

Rate this question:
8.

Which is correct dosing (Highly Emetogenic Cheotherapy) HEC?
- A.
  
  Zofran 16mg IV, Dexamethasone 20mg IV, Fosaprepitant 150mg IV
- B.
  
  Zofran 32mg IV, Dexamethasone 20mg IV, Olanzapine 10mg PO
- C.
  
  Aloxi 0.25mg IV, Dexamethasone 12mg IV, Olanzapine 10mg PO
- D.
  
  Zofran 16mg PO, Dexamethasone 12mg PO, Aprepitant 125mg PO
Correct Answer
D. Zofran 16mg PO, Dexamethasone 12mg PO, Aprepitant 125mg PO

Explanation
Zofran 32 mg is too high. Dexamethasone when used with an NK1RA, the dose needs to be 12mg.

Rate this question:
9.

Neurotransmitters involved in N/V include: (select all that apply)
- A.
  
  Dopamine
- B.
  
  Histamine
- C.
  
  Endorphins
- D.
  
  Serotonin
- E.
  
  Acetylcholine
- F.
  
  Substance P
- G.
  
  GABA
- H.
  
  Norepinephrine
- I.
  
  Glutamate
Correct Answer(s)
A. Dopamine
B. Histamine
C. EndorpHins
D. Serotonin
E. Acetylcholine
F. Substance P
G. GABA

Explanation
The neurotransmitters involved in N/V (nausea/vomiting) include dopamine, histamine, endorphins, serotonin, acetylcholine, substance P, and GABA. Nausea and vomiting can be caused by a variety of factors, including imbalances in these neurotransmitters. Dopamine, histamine, serotonin, and substance P are known to play a role in the chemoreceptor trigger zone (CTZ) in the brain, which is responsible for initiating the vomiting reflex. Endorphins, acetylcholine, and GABA can also contribute to nausea and vomiting by affecting the gastrointestinal tract and the central nervous system. Norepinephrine and glutamate are not typically associated with N/V.

Rate this question:
10.

Risk factors for Chemotherapy Induced Nausea and Vomiting (CINV) include:
- A.
  
  Age < 50
- B.
  
  Females
- C.
  
  Males
- D.
  
  Infrequent alcohol use
- E.
  
  Frequent alcohol use
- F.
  
  History of motion sickness
- G.
  
  Prior exposure to chemotherapy
- H.
  
  No previous exposure to chemotherapy
Correct Answer(s)
A. Age < 50
B. Females
D. Infrequent alcohol use
F. History of motion sickness
G. Prior exposure to chemotherapy

Explanation
The risk factors for Chemotherapy Induced Nausea and Vomiting (CINV) include being under the age of 50, being female, having infrequent alcohol use, having a history of motion sickness, and having prior exposure to chemotherapy. These factors have been found to increase the likelihood of experiencing nausea and vomiting as a side effect of chemotherapy treatment.

Rate this question:
11.

What is the correct dosing and route for Dolasetron for CINV?
- A.
  
  100mg PO
- B.
  
  100mg IV
- C.
  
  100mg topically
- D.
  
  50mg PO
Correct Answer
A. 100mg PO

Explanation
Dolasetron is only available PO.

Rate this question:
12.

What is the correct dosing and route for Granisetron for CINV? (select all that apply)
- A.
  
  2mg PO
- B.
  
  1mg IV
- C.
  
  3.1mg/hr topically (patch)
- D.
  
  1mg/hr topically (patch)
- E.
  
  2mg IV
- F.
  
  1mg PO
Correct Answer(s)
A. 2mg PO
B. 1mg IV
C. 3.1mg/hr topically (patch)

Explanation
Granisetron is a medication commonly used for the prevention and treatment of chemotherapy-induced nausea and vomiting (CINV). The correct dosing and route for Granisetron for CINV are as follows: 2mg PO (oral administration), 1mg IV (intravenous administration), and 3.1mg/hr topically (patch). These routes and doses are appropriate for managing CINV and can provide effective relief for patients undergoing chemotherapy.

Rate this question:
13.

What is the correct dosing and route for Ondansetron for CINV? (select all that apply)
- A.
  
  16-24mg PO
- B.
  
  8-16mg IV
- C.
  
  4-8mg IV
- D.
  
  4-8mg PO
Correct Answer(s)
A. 16-24mg PO
B. 8-16mg IV

Explanation
A way to help you remember: IV starts at 8 and you add 8 for the max (16). PO starts at the max of IV (16) and you add 8 again for the max (24)

Rate this question:
14.

What is the correct dosing and route for Palonsetron for CINV?
- A.
  
  0.25mg IV
- B.
  
  0.25mg PO
- C.
  
  25mg IV
- D.
  
  25mg PO
Correct Answer
A. 0.25mg IV

Explanation
The PO dosing of Palonsetron is in a combo product.

Rate this question:

1
0
15.

5-HT3 antagonists are effective for delayed CINV (Chemotherapy Induced Nausea and Vomiting).
- A.
  
  True
- B.
  
  False
Correct Answer
B. False

Explanation
They are effective for acute CINV, with the exception of Palonsetron which is effective for both acute and delayed CINV.

Rate this question:
16.

5-HT3 antagonist work by blocking enterochromaffin cells in the GI and blocking serotonin receptors in the medulla.
- A.
  
  True
- B.
  
  False
Correct Answer
A. True

Explanation
5-HT3 antagonists are a class of drugs that work by blocking the action of serotonin (5-HT3) receptors. These receptors are found in both the gastrointestinal (GI) tract and the medulla, which is a part of the brainstem. By blocking these receptors, 5-HT3 antagonists can prevent the activation of enterochromaffin cells in the GI tract, which are involved in the release of serotonin. Additionally, blocking serotonin receptors in the medulla can help to reduce nausea and vomiting, making 5-HT3 antagonists useful in the treatment of these symptoms. Therefore, the statement that 5-HT3 antagonists work by blocking enterochromaffin cells in the GI and blocking serotonin receptors in the medulla is true.

Rate this question:
17.

Increasing the dose of a 5-HT3 antagonist will always increase the antiemetic effect but will also increase the side effects.
- A.
  
  True
- B.
  
  False
Correct Answer
B. False

Explanation
The receptors that 5-HT3 antagonists work on will eventually become saturated and the response will plateau and you will not get any greater response with increasing the dose. You will however increase the side effects risk.

Rate this question:

1
0
18.

IV 5HT-3 antagonists should be given ____ prior to chemo, while PO should be given ____ prior to chemo.
- A.
  
  30; 60
- B.
  
  60; 30
- C.
  
  10; 30
- D.
  
  15; 30
Correct Answer
A. 30; 60

Explanation
IV 5HT-3 antagonists should be given 30 minutes prior to chemotherapy, while PO (oral) 5HT-3 antagonists should be given 60 minutes prior to chemotherapy.

Rate this question:
19.

To avoid QT prolongation, the dose of ondansetron should not exceed ____mg/dose.
- A.
  
  32
- B.
  
  16
- C.
  
  12
- D.
  
  48
Correct Answer
A. 32

Explanation
To avoid QT prolongation, the dose of ondansetron should not exceed 32 mg/dose. QT prolongation is a condition where the heart takes longer than usual to recharge between beats, which can lead to abnormal heart rhythms. Ondansetron is a medication commonly used to prevent nausea and vomiting. However, it has been associated with QT prolongation at higher doses. Therefore, to minimize the risk of this side effect, the recommended maximum dose of ondansetron is 32 mg per dose.

Rate this question:

1
0
20.

Dexamethasone is FDA approved for the prevention of CINV (Chemotherapy Induced Nausea and Vomiting).
- A.
  
  True
- B.
  
  False
Correct Answer
B. False

Explanation
It is used for this purpose but it is not FDA approved for this purpose.

Rate this question:
21.

Dexamethasone works synergistically with ___________ and __________ to increase effectiveness by 20-30%
- A.
  
  Metoclopramide
- B.
  
  5-HT3 antagonists
- C.
  
  Olanzapine
- D.
  
  Lorazepam
Correct Answer(s)
A. Metoclopramide
B. 5-HT3 antagonists

Explanation
Dexamethasone works synergistically with Metoclopramide and 5-HT3 antagonists to increase effectiveness by 20-30%. This means that when Dexamethasone is combined with these medications, their overall effectiveness is enhanced and they work better together than if used individually. The combination of Dexamethasone with Metoclopramide and 5-HT3 antagonists leads to a greater therapeutic effect, potentially improving patient outcomes.

Rate this question:
22.

Dexamethasone is used in acute and delayed N/V.
- A.
  
  True
- B.
  
  False
Correct Answer
A. True

Explanation
Dexamethasone is a corticosteroid medication that is commonly used to treat inflammation and suppress the immune system. It has been found to be effective in reducing nausea and vomiting (N/V) in both acute and delayed cases. This is especially useful in patients undergoing chemotherapy or radiation therapy, as these treatments often cause severe nausea and vomiting. Therefore, the statement that dexamethasone is used in acute and delayed N/V is true.

Rate this question:
23.

Dexamethasone can cause transient perineal, vaginal, and renal burning so it should be at a slow rate for IV administration.
- A.
  
  True
- B.
  
  False
Correct Answer
A. True

Explanation
Dexamethasone, a medication commonly used to reduce inflammation, can cause temporary burning sensations in the perineal area, vagina, and kidneys when administered intravenously. To minimize discomfort, it is recommended to administer the medication at a slow rate. Therefore, the statement "Dexamethasone can cause transient perineal, vaginal, and renal burning so it should be at a slow rate for IV administration" is true.

Rate this question:
24.

Dexamethasone does not have any major drug-drug interactions.
- A.
  
  True
- B.
  
  False
Correct Answer
B. False

Explanation
Dexamethasone interacts with Warfarin and the INR should be checked during concomitant use. Dexamethasone can increase the effects of warfarin sou counsel the patient to watch for dark stools.

Rate this question:
25.

Which is the correct dosing and route for Fosaprepitant for CINV?
- A.
  
  150mg IV
- B.
  
  125mg PO
- C.
  
  150mg IV
- D.
  
  80mg PO
Correct Answer
A. 150mg IV

Explanation
The correct dosing and route for Fosaprepitant for CINV is 150mg IV. This means that Fosaprepitant should be administered intravenously at a dose of 150mg.

Rate this question:
26.

Which is the correct dosing and route for Aprepitant? (Select all that apply)
- A.
  
  125mg PO
- B.
  
  80mg PO
- C.
  
  150mg IV
- D.
  
  40mg PO
Correct Answer(s)
A. 125mg PO
B. 80mg PO
D. 40mg PO

Explanation
40mg PO is for PONV and 125mg and 80mg are for CINV

Rate this question:
27.

Neurokinin-1 Receptor Antagonists (NK1RA) are used in combination with ____________ and _____________ for prevention of acute and delayed N/V associated with highly and moderately emetogenic chemotherapy.
- A.
  
  Steroids
- B.
  
  5HT-3
- C.
  
  Olanzapine
- D.
  
  Benzodiazepines
- E.
  
  Promethazine
Correct Answer(s)
A. Steroids
B. 5HT-3

Explanation
The three drugs should be taken 1 hour prior to chemo.

Rate this question:
28.

Neurokinin-1 Receptor Antagonists (NK1RA) are only approved for CINV.
- A.
  
  True
- B.
  
  False
Correct Answer
B. False

Explanation
They are approved for CINV and PONV.

Rate this question:
29.

What are some drug interactions for Aprepitant?
- A.
  
  Oral contraceptives
- B.
  
  Warfarin
- C.
  
  5-HT3 antagonists
- D.
  
  Benzodiazepines
- E.
  
  Corticosteroids
Correct Answer(s)
A. Oral contraceptives
B. Warfarin
E. Corticosteroids

Explanation
Reduces the effectiveness of oral contraceptives so patients need to use back up birth control for at least one month after using aprepitant or fosaprepitant. Aprepitant can increase the INR with Warfarin. The coritcosteroid DDI is why the dexamethasone dose needs to be decreased.

Rate this question:
30.

What is the typical dose and route(s) for prochlorperazine for CINV?
- A.
  
  10mg IV/PO q6h scheduled or PRN
- B.
  
  12.5-25mg IV q4-6h schedule or PRN
- C.
  
  1-3mg IV/PO q2-4h PRN
- D.
  
  10-40mg IV/PO q6h
Correct Answer
A. 10mg IV/PO q6h scheduled or PRN

Explanation
The typical dose and route for prochlorperazine for CINV is 10mg IV/PO q6h scheduled or PRN. This means that the recommended dose is 10mg, which can be administered either intravenously or orally every 6 hours as scheduled or as needed. This dosage regimen allows for flexibility in the administration of the medication based on the patient's symptoms and response to treatment.

Rate this question:

0
1
31.

What is the typical dose and route(s) for Promethazine for CINV?
- A.
  
  12.5-25mg IV/PO/IM/PR q4-6h schedule or PRN
- B.
  
  10mg IV/PO q6h scheduled or PRN
- C.
  
  1-3mg IV/PO q2-4h PRN
- D.
  
  10-40mg IV/PO q6h
Correct Answer
A. 12.5-25mg IV/PO/IM/PR q4-6h schedule or PRN

Explanation
The typical dose and route for Promethazine for CINV is 12.5-25mg, which can be administered intravenously, orally, intramuscularly, or rectally every 4-6 hours according to a schedule or as needed.

Rate this question:
32.

Which drug has a black box warning for irreversible tardive dyskinesias.
- A.
  
  Metoclopramide
- B.
  
  Haloperidol
- C.
  
  Promethazine
- D.
  
  Prochlorperazine
Correct Answer
A. Metoclopramide

Explanation
Metoclopramide has a black box warning for irreversible tardive dyskinesias. Tardive dyskinesia is a movement disorder characterized by involuntary, repetitive movements of the face, tongue, and extremities. It is a potentially irreversible condition that can occur with the long-term use of certain medications, particularly antipsychotics and metoclopramide. The black box warning is the strongest warning issued by the FDA, indicating the serious and potentially life-threatening risk associated with the use of metoclopramide. Therefore, it is important for healthcare providers to carefully consider the risks and benefits before prescribing metoclopramide to patients.

Rate this question:

0
1
33.

Which drug has a black box warning for QT prolongation
- A.
  
  Droperidol
- B.
  
  Promethazine
- C.
  
  Prochlorperazine
- D.
  
  Metoclopramide
Correct Answer
A. Droperidol

Explanation
Droperidol is the correct answer because it has a black box warning for QT prolongation. A black box warning is the strongest warning issued by the FDA, indicating that a drug carries a significant risk of serious or life-threatening side effects. QT prolongation is a condition that affects the heart's electrical activity and can lead to a potentially dangerous irregular heartbeat. Therefore, it is important to be cautious when prescribing or using droperidol due to this known risk.

Rate this question:
34.

What is the drug of choice for anticipatory N/V?
- A.
  
  Lorazepam
- B.
  
  Olanzapine
- C.
  
  Metoclopramide
- D.
  
  Aprepitant
Correct Answer
A. Lorazepam

Explanation
Lorazepam is the drug of choice for anticipatory N/V because it is a benzodiazepine that acts as an anxiolytic and antiemetic. It helps to reduce anxiety and prevent nausea and vomiting that can occur before a chemotherapy session or surgery. By calming the patient's nerves, Lorazepam can effectively alleviate anticipatory N/V symptoms. Olanzapine, Metoclopramide, and Aprepitant may also be used to treat N/V, but Lorazepam is specifically recommended for anticipatory N/V.

Rate this question:

1
0
35.

What is the appropriate dosing and route(s) for Lorazepam for CINV?
- A.
  
  1-2mg IV/PO/SL q4-6h PRN
- B.
  
  12.5-25mg IV/PO q4-6h PRN
- C.
  
  10-40mg IV/PO q4-6h scheduled or PRN
- D.
  
  1-2mg IV/IM q4-6h PRN
Correct Answer
A. 1-2mg IV/PO/SL q4-6h PRN

Explanation
Can also be take 1 dose prior to chemo

Rate this question:
36.

Olanzapine works for N/V because it works on multiple dopaminergic, seratonergic, muscarinic, and histmainic receptors.
- A.
  
  True
- B.
  
  False
Correct Answer
A. True

Explanation
Olanzapine is a medication that works on multiple receptors in the brain, including dopaminergic, serotonergic, muscarinic, and histaminic receptors. These receptors play a role in regulating nausea and vomiting (N/V). By affecting these receptors, olanzapine can help alleviate N/V symptoms. Therefore, the statement that "Olanzapine works for N/V because it works on multiple dopaminergic, serotonergic, muscarinic, and histaminic receptors" is true.

Rate this question:
37.

What is the dosing for Olanzapine for CINV?
- A.
  
  10mg PO daily x4d
- B.
  
  1-2mg PO daily x3d
- C.
  
  10-20mg PO daily x4d
- D.
  
  20mg PO daily x4d
Correct Answer
A. 10mg PO daily x4d

Explanation
Used in combo with 5-HT3 and steroids for prevention of highly emetogenic chemotherapy.

Rate this question:
38.

What drug/drug class can be used for breakthrough N/V? (select all that apply)
- A.
  
  5-HT3
- B.
  
  NK1RA
- C.
  
  Benzodiazepines
- D.
  
  Dopamine Antagonists
- E.
  
  Steroids
- F.
  
  Dronabinol
Correct Answer(s)
C. Benzodiazepines
D. Dopamine Antagonists
E. Steroids
F. Dronabinol

Explanation
Benzodiazepines, dopamine antagonists, steroids, and dronabinol can be used for breakthrough N/V. Benzodiazepines are central nervous system depressants that can help relieve anxiety and nausea. Dopamine antagonists, such as metoclopramide or prochlorperazine, block dopamine receptors and can reduce nausea and vomiting. Steroids, such as dexamethasone, have anti-inflammatory properties and can help reduce nausea and vomiting. Dronabinol is a synthetic form of THC, the active component of marijuana, and can help relieve nausea and vomiting.

Rate this question:

2
0
39.

Which drugs can be used for delayed N/V?
- A.
  
  Palonsetron
- B.
  
  Ondansetron
- C.
  
  Olanzapine
- D.
  
  Lorazepam
- E.
  
  Aprepitant
- F.
  
  Dexamethasone
Correct Answer(s)
A. Palonsetron
C. Olanzapine
E. Aprepitant
F. Dexamethasone

Explanation
Palonsetron, Olanzapine, Aprepitant, and Dexamethasone can be used for delayed N/V. These drugs are commonly prescribed to prevent and treat delayed nausea and vomiting, which can occur after chemotherapy or surgery. Palonsetron is a serotonin receptor antagonist that helps in reducing nausea and vomiting. Olanzapine, an antipsychotic medication, has antiemetic properties and is effective in managing delayed N/V. Aprepitant is a neurokinin-1 receptor antagonist that works by blocking the signals that trigger nausea and vomiting. Dexamethasone, a corticosteroid, helps in reducing inflammation and suppressing the immune system, thereby alleviating symptoms of delayed N/V.

Rate this question:

1
0
40.

Which drugs CANNOT be used for acute N/V?
- A.
  
  Lorazepam
- B.
  
  Promethazine
- C.
  
  Prochlorperazine
- D.
  
  Dronoabinol
- E.
  
  Dexamthasone
- F.
  
  Olanzapine
Correct Answer(s)
A. Lorazepam
B. Promethazine
C. Prochlorperazine
D. Dronoabinol

Explanation
Lorazepam, Promethazine, Prochlorperazine, and Dronabinol are all drugs that can be used for acute N/V. Lorazepam is a benzodiazepine that can help relieve nausea and vomiting by reducing anxiety. Promethazine and Prochlorperazine are both antiemetic medications that can help control nausea and vomiting. Dronabinol is a synthetic form of THC, the active component of marijuana, and is used to treat chemotherapy-induced nausea and vomiting. Therefore, the correct answer is Olanzapine, which is an antipsychotic medication and is not typically used for acute N/V.

Rate this question:
41.

Not all patients should have PRN option for breakthrough N/V.
- A.
  
  True
- B.
  
  False
Correct Answer
B. False

Explanation
ALL patients should have a PRN option. If one fails, try another or add. Use IV or PR formulations for uncontrolled N/V.

Rate this question:
42.

What should be used for a patient who has a multiple day regimen of chemo?
- A.
  
  5-HT3 antagnoist
- B.
  
  NK1RA
- C.
  
  Dopamine antagonist
- D.
  
  Benzodiazepine
Correct Answer
A. 5-HT3 antagnoist

Explanation
Palonsetron does not need to be given daily due to long half life.

Rate this question:
43.

What is the dose for Granisetron for PONV?
- A.
  
  0.5-1mg IV at end of surgery
- B.
  
  2mg IV at end of surgery
- C.
  
  0.5-1mg at induction
- D.
  
  2mg IV at induction
Correct Answer
A. 0.5-1mg IV at end of surgery

Explanation
Granisetron is a medication commonly used for the prevention and treatment of postoperative nausea and vomiting (PONV). The recommended dose of Granisetron for PONV is 0.5-1mg administered intravenously at the end of surgery. This dose helps to control nausea and vomiting that may occur after the surgical procedure. Administering the medication at the end of surgery allows for optimal effectiveness in preventing PONV.

Rate this question:
44.

What is the dose of Dolasetron in PONV?
- A.
  
  12.5mg IV at end of surgery
- B.
  
  100mg IV at end of surgery
- C.
  
  125mg IV at end of surgery
- D.
  
  25mg IV at end of surgery
Correct Answer
A. 12.5mg IV at end of surgery

Explanation
Dolasetron is a medication used to prevent postoperative nausea and vomiting (PONV). The correct dose of Dolasetron in PONV is 12.5mg IV at the end of surgery. This dose is administered intravenously and is effective in reducing the incidence of PONV. Higher doses, such as 100mg or 125mg, are not necessary and may increase the risk of side effects. A lower dose of 25mg may not provide sufficient antiemetic effect. Therefore, the recommended dose is 12.5mg IV at the end of surgery.

Rate this question:
45.

What is the dose of Ondansetron for PONV?
- A.
  
  4mg IV at end of surgery
- B.
  
  8-16mg IV at induction
- C.
  
  8-16mg IV at end of surgery
- D.
  
  4mg IV at induction
Correct Answer
A. 4mg IV at end of surgery

Explanation
The correct answer is 4mg IV at end of surgery. Ondansetron is commonly used to prevent postoperative nausea and vomiting (PONV). The recommended dose for PONV is 4mg administered intravenously at the end of surgery. This timing ensures that the medication is in the patient's system when they wake up, reducing the likelihood of experiencing nausea and vomiting as a result of anesthesia. Higher doses (8-16mg) may be used in certain cases, but the standard dose is 4mg.

Rate this question:
46.

What is the dose of Palonosetron in PONV?
- A.
  
  0.075mg IV at induction
- B.
  
  0.075mg IV at end of surgery
- C.
  
  0.25mg IV at induction
- D.
  
  0.25mg IV at end of surgery
Correct Answer
A. 0.075mg IV at induction

Explanation
Palonosetron is a medication used to prevent post-operative nausea and vomiting (PONV). The correct dose of Palonosetron in PONV is 0.075mg IV at induction. This means that the medication should be administered intravenously at the beginning of the surgery. This dose is effective in preventing nausea and vomiting that may occur after the surgery. It is important to administer the correct dose at the right time to ensure its effectiveness in managing PONV.

Rate this question:
47.

What is the dose of Dexamethasone in PONV?
- A.
  
  2.5-5mg IV at induction
- B.
  
  2.5-5mg IV at end of surgery
- C.
  
  12-20mg IV at induction
- D.
  
  12-20mg IV at end of surgery
Correct Answer
A. 2.5-5mg IV at induction

Explanation
Dexamethasone is a corticosteroid commonly used to prevent postoperative nausea and vomiting (PONV). The recommended dose of Dexamethasone in PONV is 2.5-5mg IV at induction. This means that the medication should be administered intravenously (IV) at the beginning of the surgery to help prevent nausea and vomiting from occurring during the postoperative period. The dose range of 2.5-5mg is considered effective in reducing the incidence of PONV.

Rate this question:
48.

What is the dosing for Promethazine in PONV?
- A.
  
  12.5-25mg IV at the end of surgery
- B.
  
  12.5-25mg IV at induction
- C.
  
  5-10mg IV at end of surgery
- D.
  
  5-10mg IV at induction
Correct Answer
A. 12.5-25mg IV at the end of surgery

Explanation
Promethazine is a medication commonly used for the prevention and treatment of postoperative nausea and vomiting (PONV). The correct dosing for Promethazine in PONV is 12.5-25mg IV at the end of surgery. This means that the medication should be administered intravenously in a dosage range of 12.5 to 25 milligrams at the conclusion of the surgical procedure. This timing allows for the medication to take effect and help prevent or alleviate any nausea and vomiting that may occur after surgery.

Rate this question:
49.

What is the dosing for Prochlorperazine in PONV?
- A.
  
  5-10mg IV at end of surgery
- B.
  
  5-10mg IV at induction
- C.
  
  2.5-5mg IV at induction
- D.
  
  2.5-5mg IV at end of surgery
Correct Answer
A. 5-10mg IV at end of surgery

Explanation
Prochlorperazine is a medication commonly used for the prevention and treatment of postoperative nausea and vomiting (PONV). The correct dosing for Prochlorperazine in PONV is 5-10mg intravenously (IV) at the end of surgery. This timing ensures that the medication is administered after the surgical procedure is completed, reducing the risk of PONV during the immediate postoperative period. The dose range of 5-10mg allows for individualized treatment based on the patient's needs and response to the medication. IV administration is preferred for faster onset of action and reliable absorption.

Rate this question:
50.

When used for PONV, Aprepitant should be given within 3 hours prior to induction.
- A.
  
  True
- B.
  
  False
Correct Answer
A. True

Explanation
Aprepitant is a medication commonly used to prevent postoperative nausea and vomiting (PONV). It belongs to a class of drugs known as neurokinin-1 receptor antagonists. The timing of administration is crucial for its effectiveness. Giving Aprepitant within 3 hours prior to the induction of anesthesia ensures that the drug reaches peak concentration in the body by the time surgery begins. This allows it to effectively block the neurokinin-1 receptors and prevent the occurrence of PONV. Therefore, the statement "When used for PONV, Aprepitant should be given within 3 hours prior to induction" is true.

Rate this question:

Quiz Review Timeline +

Our quizzes are rigorously reviewed, monitored and continuously updated by our expert board to maintain accuracy, relevance, and timeliness.

Current Version
Mar 22, 2023

Quiz Edited by
ProProfs Editorial Team
May 01, 2017

Quiz Created by
Ashleynecole

Nausea And Vomiting Quiz

Which 5HT-3 receptor antagonist is used for acute AND delayed N/V?

Which dose is correct when used in combination with aprepitant?

Which neurotransmitter does NK1RA (Neurokinin-1 Receptor Antagonist) affect?

Acute N/V occurs within the first...

Which drugs cause significant delayed N/V? (select all that apply)

Which NK1RA does NOT inhibit CYP3A4?

Which drug causes severe extravasation reactions?

Which is correct dosing (Highly Emetogenic Cheotherapy) HEC?

Neurotransmitters involved in N/V include: (select all that apply)

Risk factors for Chemotherapy Induced Nausea and Vomiting (CINV) include:

What is the correct dosing and route for Dolasetron for CINV?

What is the correct dosing and route for Granisetron for CINV? (select all that apply)

What is the correct dosing and route for Ondansetron for CINV? (select all that apply)

What is the correct dosing and route for Palonsetron for CINV?

5-HT3 antagonists are effective for delayed CINV (Chemotherapy Induced Nausea and Vomiting).

5-HT3 antagonist work by blocking enterochromaffin cells in the GI and blocking serotonin receptors in the medulla.

Increasing the dose of a 5-HT3 antagonist will always increase the antiemetic effect but will also increase the side effects.

IV 5HT-3 antagonists should be given ____ prior to chemo, while PO should be given ____ prior to chemo.

To avoid QT prolongation, the dose of ondansetron should not exceed ____mg/dose.

Dexamethasone is FDA approved for the prevention of CINV (Chemotherapy Induced Nausea and Vomiting).

Dexamethasone works synergistically with ___________ and __________ to increase effectiveness by 20-30%

Dexamethasone is used in acute and delayed N/V.

Dexamethasone can cause transient perineal, vaginal, and renal burning so it should be at a slow rate for IV administration.

Dexamethasone does not have any major drug-drug interactions.

Which is the correct dosing and route for Fosaprepitant for CINV?

Which is the correct dosing and route for Aprepitant? (Select all that apply)

Neurokinin-1 Receptor Antagonists (NK1RA) are used in combination with ____________ and _____________ for prevention of acute and delayed N/V associated with highly and moderately emetogenic chemotherapy.

Neurokinin-1 Receptor Antagonists (NK1RA) are only approved for CINV.

What are some drug interactions for Aprepitant?

What is the typical dose and route(s) for prochlorperazine for CINV?

What is the typical dose and route(s) for Promethazine for CINV?

Which drug has a black box warning for irreversible tardive dyskinesias.

Which drug has a black box warning for QT prolongation

What is the drug of choice for anticipatory N/V?

What is the appropriate dosing and route(s) for Lorazepam for CINV?

Olanzapine works for N/V because it works on multiple dopaminergic, seratonergic, muscarinic, and histmainic receptors.

What is the dosing for Olanzapine for CINV?

What drug/drug class can be used for breakthrough N/V? (select all that apply)

Which drugs can be used for delayed N/V?

Which drugs CANNOT be used for acute N/V?

Not all patients should have PRN option for breakthrough N/V.

What should be used for a patient who has a multiple day regimen of chemo?

What is the dose for Granisetron for PONV?

What is the dose of Dolasetron in PONV?

What is the dose of Ondansetron for PONV?

What is the dose of Palonosetron in PONV?

What is the dose of Dexamethasone in PONV?

What is the dosing for Promethazine in PONV?

What is the dosing for Prochlorperazine in PONV?

When used for PONV, Aprepitant should be given within 3 hours prior to induction.

IV 5HT-3 antagonists should be given prior to chemo, while PO should be given prior to chemo.

Dexamethasone works synergistically with _ and to increase effectiveness by 20-30%

Neurokinin-1 Receptor Antagonists (NK1RA) are used in combination with and _ for prevention of acute and delayed N/V associated with highly and moderately emetogenic chemotherapy.