Organ Pathology - Handout 4 - Red Blood Cell Disorders
Explore key concepts in red blood cell disorders with this quiz. Topics include normal hematocrit values, anemia types, and nutrient deficiencies affecting blood health. Essential for medical students and professionals to assess and reinforce their understanding of hematologic pathologies.
- 1.
A normal male hematocrit number would be
- A.
0.36
- B.
150 g/L
- C.
0.45
- D.
120 g/L
Correct Answer
C. 0.45Explanation
A normal male hematocrit number refers to the proportion of red blood cells in the total volume of blood. A hematocrit of 0.45 means that 45% of the blood volume is made up of red blood cells. This value falls within the normal range for males, indicating a healthy level of red blood cells in the bloodstream.Rate this question:
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- 2.
For an anemia of a chronic disease, what would be the most appropriate expected MCV finding?
- A.
90 fl
- B.
- C.
>100 fl
- D.
Microcytic anemia MCF
Correct Answer
A. 90 flExplanation
Chronic disease is a normocytic anemia where MCV would be between 80-100 flRate this question:
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- 3.
Iron deficiency anemia will show which? (Select 2)
- A.
Low iron
- B.
High transferrin
- C.
High ferritin
- D.
Low transferrin
Correct Answer(s)
A. Low iron
B. High transferrinExplanation
Low iron for obvious reasons. High transferrin to make as much iron available as possible.Rate this question:
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- 4.
Your patient is diagnosed with megaloblastic anemia, they are most likely deficient in what? (Select 2)
- A.
Vit. B6
- B.
Vit. B12
- C.
Folate
- D.
Vit. C
Correct Answer(s)
B. Vit. B12
C. FolateExplanation
The patient's diagnosis of megaloblastic anemia suggests a deficiency in two nutrients: folate and vitamin B12. Megaloblastic anemia is characterized by the production of abnormally large red blood cells, which are unable to function properly. Both folate and vitamin B12 are essential for the production of healthy red blood cells. Folate is necessary for DNA synthesis and cell division, while vitamin B12 is required for the maturation of red blood cells. Deficiencies in either of these nutrients can lead to the development of megaloblastic anemia.Rate this question:
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- 5.
Excessive cytokine release is characteristic of which type of anemia?
- A.
Macrocytic
- B.
Anemia of chronic disease
- C.
Iron deficiency anemia
- D.
Megaloblastic anemia
Correct Answer
B. Anemia of chronic diseaseExplanation
Excessive cytokine release is characteristic of anemia of chronic disease. Anemia of chronic disease is a type of anemia that occurs as a result of chronic inflammation or underlying medical conditions such as autoimmune diseases, chronic infections, or malignancies. In these conditions, there is an overproduction of cytokines, which are signaling molecules that regulate the immune response. The excessive cytokine release leads to a disruption in the normal production of red blood cells, resulting in anemia.Rate this question:
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- 6.
Which of the following is not true regarding aplastic anemia?
- A.
There will often be increased levels of circulating blood EPO
- B.
There will be decreased Iron
- C.
The problem is primarily attributed to chronic renal failure
- D.
It is treated with a bone marrow transplant
- E.
It is a stem cell disorder
Correct Answer
C. The problem is primarily attributed to chronic renal failureExplanation
Its pathogenesis is rooted in bone marrow failureRate this question:
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- 7.
Which one of these is the greatest contributor to End Stage Renal Disease?
- A.
High Cholesterol
- B.
Hypertension
- C.
Diabetic Retinopathy
- D.
Diabetic Nephropathy
Correct Answer
D. Diabetic NephropathyExplanation
Hypertension is second most.Rate this question:
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- 8.
One lady has Rheumatoid Arthritis and another is encompassed by toxins and radiation everyday. They both developed the same type of anemia (with very bad prognosis) because of these things. Which type of anemia is it?
- A.
Thalassemia
- B.
Aplastic Anemia
- C.
Polycythemia
- D.
Microcytic anemia
Correct Answer
B. Aplastic AnemiaExplanation
Aplastic anemia can be caused by autoimmune diseases, toxins, cancer, chemotherapy, drugs and antibiotics.Rate this question:
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- 9.
A Mediterranean girl has been advised to stay away from fava beans. Which sex-linked disorder must one of her parents have?
- A.
G6PDH deficiency
- B.
Incontinentia pigmenti
- C.
Anemia of Endocrine Failure
- D.
Hemophilia
Correct Answer
A. G6PDH deficiencyExplanation
G6PDH deficiency is a sex-linked disorder that primarily affects males. It is caused by a mutation in the gene responsible for producing the enzyme glucose-6-phosphate dehydrogenase (G6PDH). This enzyme plays a crucial role in protecting red blood cells from oxidative damage. Fava beans contain a substance called vicine, which can trigger a reaction in individuals with G6PDH deficiency, leading to the destruction of red blood cells and the development of anemia. Since the Mediterranean girl has been advised to stay away from fava beans, it suggests that one of her parents must have G6PDH deficiency.Rate this question:
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Current Version
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Mar 20, 2023Quiz Edited by
ProProfs Editorial Team -
Sep 13, 2016Quiz Created by
Eddy Sidra
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