Ready for more work on pharmacy? Today we’ll be looking at a number of different pharmaceuticals, including antiarrhythmic agents, which are used to suppress abnormal rhythms of the heart. What can you tell us about this and more?
True
False
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Nitroglycerine
Isosobide dinitrate (Isordil)
Amlodipine ( Norvasc)
Acebutolol (Sectral)
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Thiazide diuretics
Loop Diuretics
Phosphodiesterase inhibitors
Cardiac Glycosides
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I
II
III
Ib
IV
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Beta
Na+
K+
Ca++
None of the above
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Furosemide (Lasix)
Carvedilol (Coreg)
Milrinone (Primacor)
Digoxin (Lanoxin)
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IV
Misc
Ib
Ic
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True
False
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Verapamil (Calan)
Digoxin (Lanoxin)
Adenosine (Adenocard)
Flecainide (Tambocor)
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True
False
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True
False
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True
False
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Sodium Channel blockers
Class III Antiarrythmic
Have both Beta and potasium blocking properties
Rarely cause arrythmias
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Furosemide (Lasix)
Metolazone (Zaroxolyn)
Bumetanide (Bumex)
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Quinidine
Propafenone (Rythmol)
Lidocaine
Mexiletene
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COPD
Essential Tremor
Asthma
Diabetes
A & C
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Is a direct aldosterone antagonist
Prevents hyperkalemia and Na+ retention
Reverses cardiac remodeling
All of the above
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SA node 40-60
Ventricles 60-100
AV Junction 40-60
SA Node 20-40
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Flecainide (Tambocor)
Disopyramide (Norpace)
Mexiletene
A & B
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Short half life of 15 seconds
Administered PO
Negatice Inotrope, Chronotrope, and Dromotrope
DOC for acute SVT
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True
False
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Divided into 3 sections
Alters potassium concentration of cell membrane
Alters sodium concentration of cell membrane
A & C
A & B
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Lidocaine
Flecainide (Tambocor)
Adenosine (Adenocard)
Quinidine
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May be a chronic or an acute condition
Includes backwards and forward failure
Kidneys retain sodium and water
Leg and GI edema is seen in Left sided CHF
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Common first line PO drug
Relatively low risk of toxicity
Effective PVC suppressor
No serious side effects
B & D
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Lidocaine
Flecainide (Tambocor)
Propafenone (Rythmol)
Quinidine
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Available IV 400-1600mg/day and PO 150mg then increase to 360
Half life of 58 days
No serious side effects
Treat AFib/Flutter and V Tach
B & D
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Fosiniopril (Monopril)
Candesartan (Atacand)
Metoprolol (Lopressor)
Captopril (Capoten)
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Organic Nitrates
Beta Blockers
Calcium Channel Blockers
Direct Vasodilators
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Atenolol (Tenormin)
Digoxin (lanoxin)
Milrinone (Primacor)
Hydralazine (Apresoline)
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Esmolol (brevibloc)
Motoprolol (Lopressor)
Propanolol (Inderal)
Acebutolol (Sectral)
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True
False
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Left shoulder
Abdomen
Left arm
Spine
Jaw
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True
False
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Amiodarone ( Cordarone)
Adenosine (Adenocard)
Digoxin ( Lanoxin)
Dronedarone (Multaq)
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Restore and maintain normal sinus rhythm
Suppress excitable areas outside normal pathway
Control ventricular rate and optimize cardiac output
None of the above
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Positive Inotropic effects
Negative chronotropic effects
Indicated for VFib/Tachycardia
Should be used cautiously in pregnancy
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Hemodynamic compromise occurs
Decrease in myocardial oxygen demand
Potential for malignant ventricular arrhythmias
All of the above
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Adenosine (Adenocard)
Dronedarone (Multaq)
Disopyramide (Norpace)
Propafenone (Rythmol)
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Flecainide (Tambocor)
Lidocaine (Generic)
Amiodarone (Cordarone)
Ibutilide (Corvert)
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Verapamil (Calan)
Adenosine (Adenocard)
Digoxin (Lanoxin)
Dronedarone (Multaq)
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Class Ia drugs
Flecainide (Tambocor)
Lidocaine
Amiodarone (Cordarone)
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Long p-r interval
Delta wave
Long QRS complex
None of the above
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Acute abortive effect on Angina
Available in a variety of routes including topical
Contr indicated in Inferior wall MI and pregnancy
May induce bradycardia with prolonged use
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Amiodarone(Cordarone)
Class IV Antiarrhythmics
Quinidine
Adenosine (Adenocard)
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Abrupt d/c can cause rebound HTN or angina
Usually has no effect on cardiac output
Drug of choice for Prinzemtal's /variant angina
All of the above
A & C
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Milrinone (Primacor)
Nitroprusside (Nitropress)
Digoxin (Lanoxin)
Furosemide (Lasix)
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Their dosage was 300mg b.i.d
They may have had Wolff-Parkinson-White syndrome
They were using a Class 1b sodium channel blocker
All of the above
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