Pharmacodynamics: Pharmacy Exam! Quiz

1.

An antagonist does indeed cause an effect on its own.

A.

True
B.

False

Correct Answer
B. False

Explanation
The antagonist does not cause an Effect on its own It only Prevents agonist to Cause an effect.

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2

0

2.

In a desensitized receptor state, the receptor is functioning normally, but the problem lies in the ligand, which is why there is no ligand-receptor connection despite adding more ligand.

A.

True
B.

False

Correct Answer
B. False

Explanation
The receptor is what is not functioning even more you add more of the ligand.

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3.

The following are all what type of drug target/receptors? - G-protein coupled receptors - Receptors that function as enzymes - Nuclear or intracellular receptors - Ligand-gated ion channels - Transporters - Enzymes

A.

Protein
B.

Nucleic acid
C.

Lipids
D.

Telomere

Correct Answer
A. Protein

Explanation
The correct answer is protein. The question is asking about the type of drug target/receptors, and all the options listed are types of proteins that can be targeted by drugs. G-protein coupled receptors, receptors that function as enzymes, nuclear or intracellular receptors, ligand-gated ion channels, transporters, and enzymes are all examples of protein targets for drugs.

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4.

G Proteins are called "G" because ___ binds to them.

A.

Gamma subunit
B.

GTP
C.

GDP

Correct Answer
B. GTP

Explanation
G Proteins are called "G" because GTP binds to them. GTP (guanosine triphosphate) is a nucleotide that plays a crucial role in cellular signaling. When GTP binds to G proteins, it activates them, allowing them to transmit signals from cell surface receptors to intracellular signaling pathways. This binding and activation of G proteins by GTP is essential for various cellular processes, including hormone signaling, neurotransmission, and cell growth. Therefore, G proteins are named after their interaction with GTP.

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5.

A.

D
B.

D

Correct Answer
A. D

6.

Choose the best term below that matches the following definition: -Molecules that bind to a site in the receptor other than the active site and cause a conformational change that derives in a change in activity (increase or decrease) of the endogenous ligand or agonist.

A.

Second messenger (cAMP) activation
B.

Isozymatic inhibitor
C.

Allosteric modulators

Correct Answer
C. Allosteric modulators

Explanation
Allosteric modulators are molecules that bind to a site in the receptor other than the active site. When they bind, they cause a conformational change in the receptor, which leads to a change in activity of the endogenous ligand or agonist. This change can either increase or decrease the activity. In this case, the molecules described in the definition are allosteric modulators because they bind to a site other than the active site and cause a conformational change in the receptor, resulting in a change in activity of the endogenous ligand or agonist.

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7.

What drug is an example of a drug that inhibits replication/ translation /transcription after modification of nucleic acids, leading to apoptosis?

A.

Cisplatin
B.

Transferrin
C.

Ribavarin
D.

Cialis

Correct Answer
A. Cisplatin

Explanation
Cisplatin is a drug that inhibits replication, translation, and transcription after modifying nucleic acids, leading to apoptosis. It is commonly used in chemotherapy to treat various types of cancer. Cisplatin works by binding to DNA and forming cross-links, which prevents DNA from replicating and transcribing properly. This disruption in DNA function triggers apoptosis, programmed cell death, in cancer cells. Therefore, Cisplatin is an example of a drug that inhibits replication, translation, and transcription by modifying nucleic acids, ultimately leading to apoptosis.

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8.

What is an example of a drug that binds to phospholipids in the cell membrane and interrupts cell permeability?

A.

Ergosterol
B.

Cisplatin
C.

Heliox
D.

Amphotericine B

Correct Answer
D. AmpHotericine B

Explanation
Amphotericin B is an antifungal drug that binds to phospholipids in the cell membrane. By doing so, it disrupts the integrity and permeability of the cell membrane, leading to the leakage of cellular contents and ultimately causing cell death. This mechanism of action makes Amphotericin B an effective treatment for fungal infections. Ergosterol is a component of fungal cell membranes, not a drug. Cisplatin is a chemotherapy drug that works by interfering with DNA replication, not by binding to phospholipids. Heliox is a mixture of helium and oxygen gases used to improve gas exchange in certain respiratory conditions, but it does not bind to phospholipids in the cell membrane.

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9.

Signal transduction can take anywhere from:

A.

Milliseconds to hours
B.

Seconds to minutes
C.

Milliseconds to seconds
D.

Hours to days

Correct Answer
A. Milliseconds to hours

Explanation
Signal transduction refers to the process by which cells convert external signals into specific cellular responses. This process can vary in duration depending on the complexity of the signal and the cellular response required. It can range from milliseconds, for rapid signaling events such as ion channel opening, to hours, for slower processes like gene expression and protein synthesis. Therefore, signal transduction can indeed take anywhere from milliseconds to hours.

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10.

In normal situations, our body only uses 1% of our total insulin receptors.

A.

True
B.

False

Correct Answer
A. True

Explanation
In normal situations, our body only uses 1% of our total insulin receptors. This means that the majority of insulin receptors in our body are not actively engaged in insulin signaling and are therefore not being utilized. This low utilization of insulin receptors is due to the fact that our body maintains a certain level of insulin sensitivity to prevent excessive glucose uptake and maintain glucose homeostasis.

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11.

Check the factors that are of Importance for signal transduction:

A.

Ability to amplify small signals
B.

Mechanisms to protect the cell from excessive stimulation
C.

Cyclic reactions of adenyl cyclase
D.

Actication of second messengers

Correct Answer(s)
A. Ability to amplify small signals
B. Mechanisms to protect the cell from excessive stimulation

Explanation
Signal transduction is a complex process that involves the transmission of signals from the extracellular environment to the inside of the cell. The factors mentioned in the answer are important for this process. The ability to amplify small signals is crucial because it allows the cell to detect and respond to even weak signals. Mechanisms to protect the cell from excessive stimulation are also necessary to prevent overactivation of cellular processes. These mechanisms ensure that the cell responds appropriately and avoids damage.

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