Biochemistry Quiz: Lipid Metabolism

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  • 1/15 Questions

    Plasma lipids should be measured in brain stroke patients.

    • True
    • False
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About This Quiz

Explore the fundamentals of lipid metabolism in our Biochemistry Quiz. Assess your understanding of essential fatty acids, lipoprotein structures, and cholesterol transport. Ideal for students preparing for competitive exams or enhancing their academic knowledge in biochemistry.

Biochemistry Quiz: Lipid Metabolism - Quiz

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  • 2. 

    Lipoprotein lipase is located on the luminal surface of the capillary endothelium of lactating breast.

    • True

    • False

    Correct Answer
    A. True
    Explanation
    Lipoprotein lipase is an enzyme that plays a crucial role in breaking down triglycerides in circulating lipoproteins, allowing the release of fatty acids for various metabolic processes. It is primarily found on the luminal surface of the capillary endothelium in tissues that require high levels of fat metabolism, such as adipose tissue and lactating breast. Therefore, the statement that lipoprotein lipase is located on the luminal surface of the capillary endothelium of lactating breast is true.

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  • 3. 

    The polar lipid surface layer of lipoproteins consists a cholesterol.

    • True 

    • False

    Correct Answer
    A. True 
    Explanation
    The polar lipid surface layer of lipoproteins contains cholesterol. Cholesterol is a type of lipid that is essential for the structure and function of cell membranes. It plays a crucial role in maintaining the integrity and fluidity of the lipid bilayer. Lipoproteins are complexes of lipids and proteins that transport cholesterol and other lipids in the bloodstream. The polar lipid surface layer of lipoproteins contains phospholipids, which are a type of lipid, and cholesterol. Therefore, the statement is true.

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  • 4. 

    One of the following options is incorrect:

    • Cholesterol presents in dietary fat.

    • Palmitic acid is an example of Triglycerides 

    • Body can synthesize  essential FAs .

    •  Management of hypercholesterolemia reduces CVD mortality.

    Correct Answer
    A. Body can synthesize  essential FAs .
    Explanation
    The statement "Body can synthesize essential FAs" is incorrect. Essential fatty acids (EFAs) are fatty acids that cannot be synthesized by the body and must be obtained from the diet. The body can only synthesize non-essential fatty acids.

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  • 5. 

    HDL transports cholesterol to extrahepatic tissues.

    • True

    • False

    Correct Answer
    A. False
    Explanation
    High-density lipoprotein (HDL) is commonly known as "good" cholesterol because it helps remove excess cholesterol from the bloodstream and carries it back to the liver for processing and elimination. It does not transport cholesterol to extrahepatic tissues; instead, it works to prevent the buildup of cholesterol in the arteries. Therefore, the correct answer is False.

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  • 6. 

    Which of the following options is correct?

    • Cholestasis has no significant  effect on  LDL

    • Hypothyroidism increase LDL cholesterol in circulation

    • Antiretroviral drugs prevent exacerbate hyperlipidemia

    • After overnight fasting time,  if CMs cleared ,there may be a pathological disturbance.

    Correct Answer
    A. Hypothyroidism increase LDL cholesterol in circulation
    Explanation
    Hypothyroidism is a condition in which the thyroid gland does not produce enough thyroid hormone. One of the effects of hypothyroidism is an increase in LDL cholesterol levels in the blood. LDL cholesterol is often referred to as "bad" cholesterol because high levels of it can lead to the buildup of plaque in the arteries, increasing the risk of heart disease. Therefore, the statement "Hypothyroidism increases LDL cholesterol in circulation" is correct.

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  • 7. 

    Hypertriglyceridemia is a more important one compared to LDL cholesterol regarding to a risk factor of CHD.

    • True

    • False

    Correct Answer
    A. False
    Explanation
    The statement is false because LDL cholesterol is actually considered a more important risk factor for coronary heart disease (CHD) compared to hypertriglyceridemia. LDL cholesterol is often referred to as "bad" cholesterol because high levels of it can lead to the buildup of plaque in the arteries, increasing the risk of CHD. Hypertriglyceridemia, on the other hand, refers to high levels of triglycerides in the blood and is typically considered a secondary risk factor for CHD.

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  • 8. 

    Familial hypertriglyceridemia occurs due to hepatic overproduction of apoB.

    • True

    • False

    Correct Answer
    A. False
    Explanation
    Familial hypertriglyceridemia is a genetic disorder characterized by high levels of triglycerides in the blood. It is caused by mutations in genes that affect the metabolism of lipoproteins, particularly the production and clearance of apolipoprotein B (apoB) particles. These mutations can lead to impaired clearance of triglyceride-rich lipoproteins, resulting in elevated triglyceride levels. Therefore, the correct answer is False, as familial hypertriglyceridemia is not caused by hepatic overproduction of apoB, but rather by impaired clearance of triglyceride-rich lipoproteins.

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  • 9. 

    One of the following options is correct:

    • VLDL has a less mean diameter than LDL .

    • Circulating lipoproteins are  static process 

    • Apolipoprotein E can be exist in IDL

    • IDL has a higher density than HDL

    Correct Answer
    A. Apolipoprotein E can be exist in IDL
    Explanation
    Apolipoprotein E is a protein involved in the metabolism of lipoproteins. It can be found in several types of lipoproteins, including IDL (intermediate-density lipoprotein). Therefore, the statement that "Apolipoprotein E can exist in IDL" is correct.

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  • 10. 

    One of the following options is incorrect:

    • Hepatic triglyceride lipase inhibited by A-|| at high concentration .

    • Mobilizing lipase  activated by the decrease glucagon and insulin 

    • CMs transfer apoA to HDL & acquire apoC & apoE from HDL.

    • VLDL remnants are called IDL

    Correct Answer
    A. Mobilizing lipase  activated by the decrease glucagon and insulin 
    Explanation
    Mobilizing lipase is activated by the decrease in glucagon and increase in insulin, not the other way around. Glucagon stimulates the breakdown of stored glycogen into glucose, while insulin promotes the storage of glucose as glycogen. When insulin levels decrease and glucagon levels increase, it signals the body to break down stored fat for energy, activating mobilizing lipase.

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  • 11. 

    Remnant hyperlipoproteinemia increases LDL cholesterol.

    • True

    • False

    Correct Answer
    A. False
    Explanation
    Remnant hyperlipoproteinemia is a condition characterized by elevated levels of triglyceride-rich lipoproteins, such as chylomicrons and very low-density lipoproteins (VLDL). It does not directly increase LDL cholesterol levels. LDL cholesterol levels are primarily affected by other factors such as genetics, diet, and lifestyle choices. Therefore, the statement that remnant hyperlipoproteinemia increases LDL cholesterol is false.

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  • 12. 

    Which of the following options is incorrect:

    • Homozygotes familial hypercholesterolemia develop CHD in childhood.

    • Disfunction of apoE and change in their structure impaired IDL uptake by liver 

    • We use TGs with medium chain-length FAs to management the Familial hyperalphalipoproteinemia 

    • Familial defective apoB-100 is a Familial hypercholesterolemia

    Correct Answer
    A. We use TGs with medium chain-length FAs to management the Familial hyperalphalipoproteinemia 
  • 13. 

    One of the following options is correct:

    • Not all LDL is formed from VLDL

    • The number of LDL-apoB receptors on the cell surface regulated by cholesterol pool

    • C-|| inhibits clearance CM and VLDL remnant particles

    • All VLDL are formed from TGs synthesized in the liver (endogenous VLDL)

    Correct Answer
    A. The number of LDL-apoB receptors on the cell surface regulated by cholesterol pool
    Explanation
    The number of LDL-apoB receptors on the cell surface is regulated by the cholesterol pool. This means that when there is a high level of cholesterol in the body, the number of LDL-apoB receptors decreases, leading to a decrease in the uptake of LDL particles by cells. On the other hand, when the cholesterol level is low, the number of receptors increases, allowing for more LDL uptake. This regulation helps maintain cholesterol homeostasis in the body and prevents excessive accumulation of LDL particles, which can lead to health issues such as atherosclerosis.

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  • 14. 

    Which of the following options is incorrect?

    • There is no effect after menopause regarding to plasma lipoproteins

    •  Increasing risk of acute pancreatitis when plasma TG concentration > 10 m mol/L 

    • High P/S ratio increase LDL cholesterol 

    • Small dense TG-rich LDL particles related to the third type of LDL 

    Correct Answer
    A. High P/S ratio increase LDL cholesterol 
    Explanation
    The incorrect option is "High P/S ratio increase LDL cholesterol." This statement is incorrect because a high polyunsaturated to saturated (P/S) ratio actually decreases LDL cholesterol levels.

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  • 15. 

    Which of the following options is correct?

    • Nicotinic acid bind with bile acids in the gut  prevent their absorption

    • Statins (HMG-CoA reductase inhibitors ) are the main treatment for hypertriglyceridemia:

    • Tangier disease reduced HDL levels.

    • CM, VLDL & LDL are absent from the plasma in Hypobetalipoproteinemia 

    Correct Answer
    A. Tangier disease reduced HDL levels.
    Explanation
    Tangier disease is a rare genetic disorder characterized by the absence or severe reduction of high-density lipoprotein (HDL) levels in the blood. HDL is responsible for removing cholesterol from the bloodstream and transporting it to the liver for excretion. In Tangier disease, the lack of functional HDL leads to the accumulation of cholesterol in various tissues, including the tonsils, spleen, and liver. Therefore, the statement that Tangier disease reduces HDL levels is correct.

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  • Current Version
  • Mar 21, 2023
    Quiz Edited by
    ProProfs Editorial Team
  • Dec 29, 2020
    Quiz Created by
    Catherine Halcomb
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