Female Reproductive System Lesson: Anatomy, Functions, Structures, And Disorders
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The female reproductive system comprises a complex network of organs, including the ovaries, uterus, fallopian tubes, and vagina, responsible for gamete production, fertilization, and gestation. Its primary functions are the production of ova, facilitation of fertilization, and maintenance of pregnancy.
The system is also crucial in regulating endocrine functions, particularly the synthesis and release of estrogen and progesterone, which control reproductive cycles and influence various physiological processes. Its role is integral to reproductive health, fertility, and the continuation of species through sexual reproduction.
Female Reproductive System Anatomy and Functions
The female reproductive system consists of internal and external structures responsible for reproduction, hormone production, and maintaining sexual health. The key organs include the ovaries, fallopian tubes, uterus, and vagina.
External Female Genitalia
The external female genitalia, or vulva, includes the labia, clitoris, and vaginal and urethral openings, protecting internal reproductive organs and supporting sexual and urinary functions.
The Vulva
The vulva is the external part of the female genitalia, encompassing several structures, including the labia majora, labia minora, clitoris, and the vaginal and urethral openings. Its primary function is to protect the internal reproductive organs, support urinary functions, and facilitate reproductive processes.
Histology The vulva is covered by keratinized stratified squamous epithelium, with underlying connective tissue containing sebaceous and sweat glands. It provides protection and sensory function, with regions of dense innervation for tactile sensitivity.
The Labia (Majora and Minora)
The labia majora are the larger, outer folds of skin that provide protection for the inner structures of the vulva. The labia minora are the smaller, inner folds that protect the vaginal and urethral openings and assist in maintaining moisture and cleanliness.
Histology The labia majora have keratinized stratified squamous epithelium, sebaceous glands, and adipose tissue. The labia minora, lacking adipose tissue, are lined by non-keratinized stratified squamous epithelium and contain sebaceous glands, blood vessels, and elastic fibers.
The Clitoris
The clitoris is located near the junction of the labia minora and plays a role in reproductive health. Its structure includes a dense network of nerves and blood vessels, though it does not directly contribute to the reproductive process.
Histology The clitoris is composed of erectile tissue, covered by non-keratinized stratified squamous epithelium. It contains a dense network of nerve endings and blood vessels, enabling sensory response and blood engorgement during arousal.
The Urethral and Vaginal Openings
The urethral opening allows for the excretion of urine from the body, while the vaginal opening is involved in menstrual flow, childbirth, and reproductive functions. Both are essential components of the female external genitalia, supporting urinary and reproductive health.
Histology The urethral opening is lined with transitional epithelium, transitioning to stratified squamous epithelium near the external surface. The vaginal opening is lined with non-keratinized stratified squamous epithelium, providing protection and flexibility.
Internal Female Genitalia
The internal female genitalia include the ovaries, fallopian tubes, uterus, and vagina, responsible for egg production, fertilization, fetal development, and childbirth processes.
Fig: Labeled Diagram of the Female Reproductive System
The Vagina
The vagina is a muscular, tubular structure that connects the external genitalia to the cervix. It serves as the canal for menstrual flow, childbirth, and the pathway through which sperm enters during reproduction. The vaginal walls are flexible and lined with mucous membranes, aiding in its ability to accommodate various functions.
Histology The vagina is lined with stratified squamous epithelium, providing protection. Underneath is a lamina propria rich in blood vessels, with smooth muscle layers for flexibility and strength.
The Cervix
The cervix is the lower part of the uterus, acting as a gateway between the vagina and the uterine cavity. It produces mucus that changes in consistency throughout the menstrual cycle, facilitating or hindering sperm movement. The cervix also dilates during childbirth to allow for the passage of the baby.
Histology The cervical tissue is mainly lined by stratified squamous epithelium in its external portion, while the endocervix is lined by simple columnar epithelial cells, which produce cervical mucus important for sperm passage.
The Uterus
The uterus is a hollow, pear-shaped organ where fetal development occurs.
Histology
Endometrium The endometrium is the innermost layer of the uterus, where implantation of a fertilized egg occurs. Its histology can be divided into two main regions:
Stratum functionalis This is the superficial layer that thickens and sheds during each menstrual cycle. It consists of simple columnar epithelium, along with a stroma that contains uterine glands, which provide nourishment for a developing embryo.
Stratum basalis The deeper layer that remains constant throughout the menstrual cycle and regenerates the stratum functionalis after menstruation. The cellular composition includes fibroblasts and dense connective tissue, supporting the regenerative process.
Myometrium The myometrium is the thick muscular layer of the uterus composed of smooth muscle fibers. It plays a critical role in contractions during childbirth and menstruation. The muscle cells are oriented in three distinct layers
Inner longitudinal layer This facilitates uterine contractions during menstruation.
Middle circular layer This is the thickest layer, responsible for the powerful contractions during labor.
Outer longitudinal layer This works together with the other two layers to expel the fetus during childbirth.
Perimetrium The perimetrium is the outermost layer of the uterus, consisting of a thin serous membrane made of simple squamous epithelium, providing a smooth, protective outer covering.
The Fallopian Tubes
The fallopian tubes extend from the ovaries to the uterus. They play a critical role in reproduction, as they are the site where fertilization occurs. Once an egg is released from the ovary, it travels through the fallopian tube toward the uterus.
Histology The inner lining of the fallopian tubes consists of ciliated columnar epithelial cells, which facilitate the movement of the egg toward the uterus. Non-ciliated secretory cells, known as peg cells, secrete nutrients to support both the egg and sperm.
The Ovaries
The ovaries are small, almond-shaped organs located on either side of the uterus. They are responsible for producing eggs (ova) and releasing reproductive hormones, including estrogen and progesterone. The ovaries play a key role in regulating the menstrual cycle and are essential for reproduction.
Histology The ovarian tissue is composed of follicles, each containing an oocyte (immature egg cell) surrounded by granulosa cells, which secrete hormones like estrogen and progesterone. The outer layer of the ovaries consists of germinal epithelium, a simple cuboidal epithelium, and the ovarian stroma, rich in connective tissue.
The menstrual cycle is a complex, cyclical process that prepares the female reproductive system for potential pregnancy. It typically lasts 28 days but can vary between individuals. The cycle is divided into distinct phases, each characterized by specific hormonal changes and physiological events in the ovaries and uterus.
The cycle is regulated primarily by the hormones estrogen and progesterone, along with luteinizing hormone (LH) and follicle-stimulating hormone (FSH). The menstrual cycle begins at menarche (the onset of menstruation during puberty) and ends at menopause (the permanent cessation of menstruation).
Hormonal Regulation
Estrogen Estrogen is a steroid hormone produced mainly by the ovaries, with additional production in the adrenal glands and fat tissue. It is crucial for the development of female secondary sexual characteristics, such as breast development and the distribution of body fat. Estrogen also regulates bone density, cardiovascular health, and maintains the reproductive tissues' structure and function.
Progesterone Progesterone is produced by the corpus luteum in the ovaries and plays a vital role in regulating reproductive health. It supports the maintenance of pregnancy by preparing the uterus for embryo implantation, modulating the immune response to avoid rejection of the fetus, and preventing uterine contractions that could lead to premature labor.
Luteinizing Hormone (LH) LH is a glycoprotein hormone produced by the anterior pituitary gland. It stimulates the production of sex steroids (estrogen and testosterone) by acting on the gonads. In females, LH promotes the maturation of ovarian follicles and supports the production of progesterone in the corpus luteum.
Follicle-Stimulating Hormone (FSH) FSH is a key hormone for reproductive health, secreted by the anterior pituitary gland. It stimulates the growth and maturation of ovarian follicles in females and aids in spermatogenesis in males. FSH also regulates the production of sex hormones, including estrogen, by acting on the gonads.
Menarche
Menarche refers to the first occurrence of menstruation, typically occurring between the ages of 11 and 14, though the timing can vary depending on genetic, nutritional, and environmental factors. Menarche marks the onset of reproductive capability, indicating that the ovaries have begun to produce mature ova. The first few menstrual cycles after menarche may be irregular as the hypothalamic-pituitary-ovarian axis matures and establishes regular hormonal rhythms.
Phases of the Menstrual Cycle
Fig: Hormonal fluctuations during the menstrual cycle
Follicular Phase The follicular phase is the first phase of the menstrual cycle, starting on the first day of menstruation and lasting until ovulation. It typically spans from day 1 to day 14, though this can vary. During this phase
Ovarian Activity FSH, secreted by the anterior pituitary gland, stimulates the growth of ovarian follicles. As the follicles mature, they begin to secrete increasing amounts of estrogen.
Endometrial Activity Under the influence of estrogen, the endometrium (uterine lining) begins to thicken and regenerate from the previous cycle's shedding. This is known as the proliferative phase of the endometrial cycle.
Hormonal Changes Estrogen levels gradually increase, leading to a negative feedback loop that reduces FSH secretion while promoting LH secretion.
Fig: Graph representing changes in endometrial thickness throughout the menstrual cycle.
Ovulatory Phase The ovulatory phase is the shortest but critical phase, typically occurring around day 14 of a 28-day cycle. It marks the release of an egg from the dominant follicle in the ovary. Key aspects include
Hormonal Surge A surge in LH, triggered by high estrogen levels, induces ovulation. The sudden rise in LH is known as the "LH surge," which leads to the rupture of the mature follicle and the release of an oocyte (egg).
Endometrial Activity The endometrium continues to thicken in preparation for potential implantation of a fertilized egg.
Fertilization Window The egg, once released, travels into the fallopian tube, where it remains viable for fertilization for approximately 12-24 hours. If fertilization does not occur, the cycle moves into the luteal phase.
Luteal Phase The luteal phase follows ovulation and lasts about 14 days, from day 15 to 28. During this phase
Corpus Luteum Formation The ruptured follicle transforms into the corpus luteum, a temporary endocrine structure that secretes progesterone and some estrogen. Progesterone is crucial for maintaining the thickened endometrium and preparing it for potential implantation.
Endometrial Activity This phase corresponds to the secretory phase of the endometrial cycle. The endometrium becomes more glandular and vascularized, creating an optimal environment for a fertilized egg to implant.
Hormonal Decline If fertilization and implantation do not occur, the corpus luteum degenerates, leading to a sharp decline in progesterone and estrogen levels. This hormonal drop causes the endometrium to shed, marking the onset of menstruation and the start of a new cycle.
Menopause
Menopause signifies the permanent cessation of menstruation and reproductive capacity, typically occurring between the ages of 45 and 55. It is preceded by perimenopause, a transitional phase characterized by irregular menstrual cycles and fluctuating hormone levels. Menopause occurs when the ovaries no longer produce sufficient amounts of estrogen and progesterone, leading to the cessation of ovulation and menstruation. The decline in hormone levels also causes various systemic effects, such as hot flashes, mood changes, and an increased risk of osteoporosis and cardiovascular disease due to reduced estrogen levels.
Oogenesis and Follicular Development
Oogenesis is the process of egg (oocyte) formation and maturation within the ovaries, while follicular development refers to the growth and maturation of the ovarian follicles that support the developing oocyte. This process is crucial for female fertility and occurs in several stages, from early fetal development through adulthood, culminating in the release of a mature egg during ovulation.
Process of Oocyte Formation
Fig: Stages of the ovarian follicle development during the menstrual cycle
Oogenesis begins during fetal development and follows these key stages
Primordial Germ Cells In the early embryo, primordial germ cells migrate to the developing ovaries, where they differentiate into oogonia, the precursor cells to oocytes.
Oogonia Proliferation Oogonia undergo rapid mitotic divisions, resulting in a large number of cells by the fifth month of fetal development. At this point, they enter the first stage of meiosis, a specialized type of cell division.
Primary Oocytes Oogonia transform into primary oocytes after beginning meiosis I. However, meiosis halts at prophase I, and the primary oocytes remain arrested in this stage until puberty.
Meiotic Arrest and Dormancy From birth to puberty, all oocytes are in a state of dormancy. At birth, females have approximately 1-2 million primary oocytes, but many undergo degeneration (atresia) during childhood, leaving around 400,000 at puberty.
Ovulation and Completion of Meiosis I With each menstrual cycle after puberty, a cohort of primary oocytes resumes meiosis in response to hormonal signals. Only one oocyte typically completes meiosis I to become a secondary oocyte, which is released during ovulation. The secondary oocyte enters meiosis II but halts at metaphase II and only completes the process if fertilization occurs.
Stages of Follicle Maturation
Follicular development occurs in tandem with oogenesis, supporting the oocyte as it matures. The stages of follicular maturation are as follows
Primordial Follicle At birth, primary oocytes are surrounded by a single layer of flat granulosa cells, forming primordial follicles. These remain dormant until activated during puberty.
Primary Follicle Upon activation, a primordial follicle matures into a primary follicle, characterized by the transformation of granulosa cells from flat to cuboidal. The primary oocyte grows, and the zona pellucida, a glycoprotein layer surrounding the oocyte, begins to form.
Secondary Follicle As the follicle continues to grow, additional layers of granulosa cells form around the oocyte. The surrounding stromal cells develop into theca cells, which play a role in hormone production. A fluid-filled cavity called the antrum begins to develop within the follicle.
Tertiary (Antral) Follicle The tertiary follicle is marked by a large antrum filled with follicular fluid. At this stage, the follicle secretes increasing amounts of estrogen. Only one follicle, known as the dominant follicle, typically reaches full maturation, while the others in the cohort undergo atresia.
Graafian (Mature) Follicle The Graafian follicle is the final stage of follicular maturation. The antrum is fully developed, and the oocyte is surrounded by a specialized structure called the cumulus oophorus, which helps facilitate release during ovulation. The oocyte is ready to be ovulated, and the follicle ruptures, releasing the secondary oocyte.
Fertilization is a complex biological event where a sperm cell fuses with an oocyte (egg) to form a zygote, the first stage of human life. This process typically occurs in the ampulla, the widest section of the fallopian tube. The events of fertilization are highly regulated and involve several key stages:
Fig: Stages of fertilization, beginning with the sperm entering the egg, forming a zygote
Sperm Transport and Capacitation
After ejaculation, sperm cells must travel through the female reproductive tract, passing through the cervix and uterus into the fallopian tubes. This journey is facilitated by contractions of the female reproductive tract and the motility of the sperm.
In the female reproductive tract, sperm undergo capacitation, a process that enhances their ability to penetrate the egg. During capacitation, the sperm's plasma membrane is altered, allowing it to become more responsive to the signals emitted by the oocyte.
Oocyte Transport
Once ovulated, the secondary oocyte is captured by the fimbriae, finger-like projections at the end of the fallopian tube, and transported toward the site of fertilization in the ampulla.
The oocyte remains viable for approximately 12-24 hours after ovulation. If not fertilized within this timeframe, it will degenerate.
Sperm Penetration and the Acrosomal Reaction
Upon reaching the oocyte, sperm must penetrate several layers surrounding the egg
Corona Radiata The outer layer composed of granulosa cells that protect the oocyte.
Zona Pellucida A thick glycoprotein layer that surrounds the oocyte and acts as a barrier to sperm entry.
To penetrate the zona pellucida, the sperm undergoes the acrosomal reaction, during which the acrosome (a cap-like structure on the sperm head) releases digestive enzymes. These enzymes, such as hyaluronidase, break down the zona pellucida, allowing the sperm to reach the oocyte membrane.
Fusion of Sperm and Oocyte Membranes
Once a sperm successfully penetrates the zona pellucida, it binds to specific receptors on the oocyte membrane. This triggers the fusion of the sperm and oocyte plasma membranes, allowing the sperm's nucleus and other cellular components to enter the oocyte.
Upon fusion, the oocyte undergoes its final meiotic division, completing meiosis II and forming a mature oocyte and a small polar body (which degenerates).
Cortical Reaction and Prevention of Polyspermy
To prevent multiple sperm from fertilizing the oocyte, the cortical reaction occurs. This reaction involves the release of cortical granules from the oocyte into the space between the oocyte membrane and the zona pellucida.
These granules alter the zona pellucida's structure, making it impermeable to additional sperm, thus ensuring that only one sperm fertilizes the oocyte (a process called monospermy).
Fusion of Genetic Material and Formation of the Zygote
After the sperm enters the oocyte, the nuclei of both the sperm and the oocyte, now called pronuclei, approach each other. The two sets of chromosomes (one from each parent) align and fuse, combining their genetic material.
The result is a zygote, a diploid cell with 46 chromosomes, which is the first stage in human development.
Initiation of Zygote Division and Early Development
The newly formed zygote immediately begins to undergo a series of rapid mitotic divisions called cleavage as it travels down the fallopian tube toward the uterus. These divisions increase the number of cells without increasing the overall size of the zygote.
Within a few days, the zygote transforms into a blastocyst, which eventually implants into the uterine wall to begin the process of embryogenesis.
Implantation and Pregnancy
Implantation and the establishment of pregnancy are complex processes that follow fertilization. Implantation refers to the attachment of the blastocyst (the early stage of the embryo) to the uterine wall, while pregnancy involves the subsequent growth and development of the embryo and fetus within the uterus.
Transport of the Blastocyst
After fertilization, the zygote undergoes multiple mitotic divisions as it travels through the fallopian tube toward the uterus. By the time the zygote reaches the uterus (around days 5-7 post-fertilization), it has developed into a blastocyst, a hollow sphere of cells with an inner cell mass that will form the embryo.
Blastocyst Hatching
Before implantation, the blastocyst must "hatch" from the zona pellucida, a glycoprotein layer that surrounded the embryo during earlier stages. The blastocyst sheds this outer layer, allowing direct contact with the endometrial lining of the uterus, which is in the secretory phase of the endometrial cycle, prepared to support implantation.
Apposition and Adhesion
The process of implantation begins with apposition, where the blastocyst loosely attaches to the endometrial surface, typically in the upper posterior wall of the uterus. The blastocyst then undergoes adhesion, where specialized trophoblast cells from the outer layer of the blastocyst firmly attach to the endometrial epithelial cells. This firm attachment is essential for the blastocyst to establish a connection with the maternal blood supply.
Invasion of the Endometrium
The trophoblast cells differentiate into two layers:
Cytotrophoblast: The inner layer of cells that maintains the structural integrity of the blastocyst.
Syncytiotrophoblast: The outer layer, which invades the endometrial tissue, secreting enzymes that allow the blastocyst to embed into the uterine wall. These enzymes break down the extracellular matrix of the endometrium, enabling the blastocyst to burrow deeper into the tissue.
Once embedded, the blastocyst is surrounded by maternal tissue and begins to establish the early stages of the placenta. This invasion triggers changes in the endometrial lining, transforming it into the decidua, a thickened, nutrient-rich layer that supports embryonic growth.
Formation of the Placenta
The placenta is a specialized organ that forms after implantation, providing the interface between the mother and the developing embryo (and later, the fetus). The placenta facilitates the exchange of nutrients, gases, and waste products between the maternal and fetal blood supplies. It also produces key hormones, such as human chorionic gonadotropin (hCG), progesterone, and estrogen, which are critical for maintaining pregnancy.
hCG This is produced by the syncytiotrophoblast, hCG maintains the corpus luteum during early pregnancy, ensuring continued production of progesterone, which supports the endometrial lining.
Progesterone This is essential for maintaining the thickened endometrium and suppressing uterine contractions, preventing the early expulsion of the developing embryo.
Estrogen This plays a vital role in stimulating the growth of the uterus, increasing blood flow, and developing the mammary glands for lactation.
Embryonic Development
Following implantation, the inner cell mass of the blastocyst differentiates into three germ layers-ectoderm, mesoderm, and endoderm-that will give rise to all tissues and organs in the body. This process is known as gastrulation. By the end of the second week post-fertilization, the blastocyst has developed into an embryo.
Embryogenesis Embryogenesis occurs over the first eight weeks of pregnancy. During this period, the embryo's major organs and structures begin to form. This period is crucial for the development of the brain, heart, limbs, and spinal cord.
Fetal Development
After eight weeks, the embryo is referred to as a fetus, and the remaining time of gestation is spent in further developing the organs and systems that formed during the embryonic period. The placenta continues to grow and facilitate the exchange of oxygen, nutrients, and waste between mother and fetus.
Maternal Adaptations to Pregnancy
Throughout pregnancy, the maternal body undergoes significant physiological changes to support fetal development. These include:
Cardiovascular changes Increased blood volume and cardiac output to supply the placenta.
Hormonal changes Elevated levels of progesterone, estrogen, and hCG maintain pregnancy and prepare the mother's body for childbirth and lactation.
Metabolic changes Increased metabolism to support the growing fetus, along with the storage of energy reserves in the form of fat.
Implantation
Implantation is the process where the fertilized egg, now a blastocyst, attaches itself to the endometrial lining of the uterus. It typically occurs about 6 to 10 days after fertilization. Implantation is a critical stage of pregnancy, and failures in this process are a leading cause of early pregnancy loss. Several factors can contribute to failed implantation or early miscarriage, including
Chromosomal abnormalities in the embryo.
Endometrial receptivity issues, where the uterine lining is not properly prepared to support implantation.
Immune response problems, where the maternal immune system may attack the developing embryo.
Hormonal imbalances, particularly in progesterone or estrogen levels, can disrupt the normal processes of implantation.
In cases where implantation occurs outside the uterus (such as in an ectopic pregnancy), the pregnancy cannot proceed normally, and medical intervention is required to prevent complications.
Reproductive System Disorders
Reproductive system disorders in females can affect various components of the reproductive organs, impacting fertility, hormonal balance, menstruation, and overall reproductive health. These disorders may arise due to genetic factors, infections, hormonal imbalances, or anatomical abnormalities.
Polycystic Ovary Syndrome (PCOS) A common endocrine disorder characterized by hormonal imbalances, irregular menstrual cycles, and elevated androgen levels. Symptoms include hirsutism, acne, and infertility due to lack of ovulation. Treatment options include lifestyle modifications, hormonal contraceptives to regulate periods, and medications like clomiphene to induce ovulation.
Endometriosis A chronic condition where endometrial-like tissue grows outside the uterus, often on the ovaries and fallopian tubes. It causes pelvic pain, heavy menstrual bleeding, and infertility. Treatments include pain management, hormonal therapy (e.g., birth control), and surgical removal of endometrial tissue in severe cases.
Uterine Fibroids Non-cancerous growths in the uterus that can cause heavy periods, pelvic pain, and fertility issues. Treatment options include medication to shrink fibroids, minimally invasive procedures like uterine artery embolization, or surgery (myomectomy or hysterectomy) in severe cases.
Ovarian Cysts Fluid-filled sacs that form on or inside the ovaries. Most are benign and resolve naturally, but larger cysts can cause abdominal pain, bloating, or affect fertility. Treatment may involve monitoring, hormonal birth control, or surgery if the cyst is persistent or symptomatic.
Pelvic Inflammatory Disease (PID) An infection of the female reproductive organs, often resulting from sexually transmitted infections (STIs) like chlamydia or gonorrhea. Symptoms include pelvic pain, fever, and abnormal discharge. If untreated, PID can lead to infertility. Antibiotics are the primary treatment, and early detection is crucial to prevent complications.
Premature Ovarian Insufficiency (POI) The loss of normal ovarian function before age 40, leading to decreased estrogen levels, irregular periods, and early menopause-like symptoms. It often results in infertility. Treatment typically involves hormone replacement therapy (HRT) to manage symptoms, and fertility treatments may be required for those wishing to conceive.
Reproductive Health in Women
Reproductive health in women refers to the well-being of the reproductive system, encompassing physical, mental, and social aspects of female reproductive functioning. It involves the proper functioning of the female reproductive system structures and ensuring the ability to conceive, carry a pregnancy to term, and maintain hormonal balance. Key aspects include
Menstrual Health A regular menstrual cycle is an indicator of reproductive health. Irregularities, such as amenorrhea or heavy bleeding, may signal underlying issues like hormonal imbalances or reproductive disorders.
Sexual Health Safe and consensual sexual practices, as well as protection from sexually transmitted infections (STIs), are crucial components of reproductive health.
Pregnancy and Childbirth Good reproductive health ensures a woman's ability to carry a pregnancy safely. Proper prenatal care, nutrition, and medical support are essential for a healthy pregnancy and childbirth.
Preventive Care Regular check-ups, including pelvic exams, Pap smears, and mammograms, are vital for early detection of reproductive health issues, such as cervical or breast cancer.
Hormonal Health Balanced hormone levels, including estrogen and progesterone, are crucial for regulating the menstrual cycle, pregnancy, and menopause. Hormonal imbalances can lead to conditions such as infertility, mood disorders, or menopause-related issues.
In this lesson, we learned about the detailed female reproductive system anatomy and its various components, gaining an understanding of how the female reproductive system parts work together. We understood the female reproductive system structures and learned about their essential roles in key female reproductive system functions such as menstruation, ovulation, and pregnancy.
Academically, this knowledge is fundamental for fields such as biology, medicine, and health sciences, providing a solid foundation for further studies on human reproduction and reproductive