COP 2015 Pharmaceutics Lecture 08/17/2011

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Questions: 15 | Attempts: 61 | Updated: Jun 19, 2024

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Questions and Answers

1.

The cation K⁺, when added to a solution, increases the pH of that solution.
- A.
  
  True
- B.
  
  False
Correct Answer
B. False

Explanation
The cation K+ does not have any direct effect on the pH of a solution. The pH of a solution is determined by the concentration of hydrogen ions (H+) present in the solution. K+ does not contribute or affect the concentration of H+ ions, so it does not have any impact on the pH. Therefore, the statement is false.

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2.

Strong bases, such as NaOH, produce strong conjugate acids.
- A.
  
  True
- B.
  
  False
Correct Answer
B. False

Explanation
Strong bases, such as NaOH, produce weak conjugate acids. This is because strong bases completely dissociate in water, yielding hydroxide ions (OH-) which are strong bases themselves. When a strong base reacts with water, it forms a weak conjugate acid and hydroxide ions. Therefore, the statement that strong bases produce strong conjugate acids is false.

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3.

Which of the following would decrease the pH of a solution?
- A.
  
  Li+
- B.
  
  Cl-
- C.
  
  Fe3+
- D.
  
  NO3-
Correct Answer
C. Fe3+

Explanation
Fe3+ would decrease the pH of a solution because it is a strong Lewis acid that can accept a pair of electrons from a water molecule, forming a hydronium ion (H3O+). The presence of more hydronium ions in a solution increases its acidity, resulting in a decrease in pH.

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4.

Which of the following is the correct K_b expression for the above reaction?
- A.
  
  A
- B.
  
  B
- C.
  
  C
- D.
  
  D
Correct Answer
C. C
5.

When water is part of an acid/base reaction, H₂O is always included in the K_a and K_bexpressions as either a reactant or a product.
- A.
  
  True
- B.
  
  False
Correct Answer
B. False

Explanation
In an acid/base reaction, water is not always included in the Ka and Kb expressions as either a reactant or a product. This is because water is considered to be a solvent in these reactions and does not participate as a reactant or a product. The Ka and Kb expressions only include the concentration of the acid or base species involved in the reaction, not water.

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6.

All transition metals, when added to solution, will cause the solution to:
- A.
  
  Become more basic
- B.
  
  Increase in pH
- C.
  
  Both become more basic and decrease the pH
- D.
  
  Become more acidic
Correct Answer
D. Become more acidic

Explanation
When transition metals are added to a solution, they tend to act as Lewis acids by accepting electron pairs from water molecules. This results in the formation of hydronium ions (H3O+), leading to an increase in the concentration of H+ ions in the solution. Therefore, the pH of the solution decreases, indicating that it becomes more acidic.

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7.

Fentanyl is used to induce anesthesia during hyperthermic treatment. During this treatment patients take longer to wake up because the Fentanyl is more active. Why is Fentanyl more active at higher temperatures? At 37C the pK_a of Fentanyl is 8.22 At 42C the pK_a of Fentanyl is 8.05
- A.
  
  At the higher temperature, there is more charged Fentanyl. This allows it to be more reactive.
- B.
  
  The higher temperature causes there to be more uncharged Fentanyl and therefore the Fentanyl is more hydrophillic
- C.
  
  At the higher temperature, Fentanyl will be more uncharged than at lower temperatures, causing it to be absorbed easier and therfore more active
Correct Answer
C. At the higher temperature, Fentanyl will be more uncharged than at lower temperatures, causing it to be absorbed easier and therfore more active

Explanation
At higher temperatures, the pKa of Fentanyl decreases from 8.22 to 8.05. This means that at the higher temperature, Fentanyl will be more uncharged compared to lower temperatures. Since uncharged molecules are more lipophilic, they can easily cross cell membranes and be absorbed more easily. This increased absorption leads to Fentanyl being more active at higher temperatures during hyperthermic treatment.

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8.

Fentanyl is used to induce anesthesia during hyperthermic treatment. During this treatment patients take longer to wake up because the Fentanyl is more active. During this treatment, Fentanyl will exist mostly in: At 37C the pK_a of Fentanyl is 8.22 At 42C the pK_a of Fentanyl is 8.05
- A.
  
  An acid state
- B.
  
  An ionized state
- C.
  
  An uncharged state
Correct Answer
C. An uncharged state

Explanation
Fentanyl exists mostly in an uncharged state during hyperthermic treatment. The pKa value of Fentanyl at both 37°C and 42°C is above the physiological pH of the body, which means that the majority of the Fentanyl molecules will remain uncharged. In an uncharged state, Fentanyl can easily cross cell membranes and reach its target sites, allowing it to be more active and induce anesthesia effectively.

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9.

Aspirin is an acidic drug that follows this basic equation: The pH of the ileum (the last portion of the small intestine) ranges from 7.0 - 8.0. Aspirin will be readily absorbed in the ileum.
- A.
  
  True
- B.
  
  False
Correct Answer
B. False

Explanation
Aspirin is a weak acid that ionizes in water to form its conjugate base. The pH of the ileum is alkaline, ranging from 7.0 - 8.0. In an alkaline environment, weak acids tend to remain in their non-ionized form, which is less soluble and less readily absorbed. Therefore, aspirin is less likely to be readily absorbed in the ileum.

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10.

For most drugs, the majority of absorption occurs in the duodenum.
- A.
  
  True
- B.
  
  False
Correct Answer
A. True

Explanation
The duodenum is the first part of the small intestine where the majority of digestion and absorption of nutrients takes place. It has a large surface area and is lined with villi, which are finger-like projections that increase the absorption capacity. Therefore, it is logical to assume that most drugs would be absorbed in the duodenum due to its favorable conditions for absorption.

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11.

Aniline is shown in this figure. The pK_a of Aniline is 4.6. Calculate the pH of a 0.03M Aniline solution.
- A.
  
  8.54
- B.
  
  9.2
- C.
  
  7.0
- D.
  
  3.5
Correct Answer
A. 8.54

Explanation
Aniline is a weak base, and its pKa value indicates the pH at which it is half dissociated. In this case, since the pKa is 4.6, the pH of the solution can be calculated using the Henderson-Hasselbalch equation: pH = pKa + log ([A-]/[HA]). In this equation, [A-] represents the concentration of the conjugate base (Aniline-) and [HA] represents the concentration of the weak base (Aniline). Since the concentration of Aniline is given as 0.03M, and the concentration of Aniline- can be assumed to be negligible, the equation simplifies to pH = pKa + log (0.03/0.03). By substituting the values, the pH is calculated to be 8.54.

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12.

Morphine is a basic drug. Morphine would exist mostly charged in the acidic stomach.
- A.
  
  True
- B.
  
  False
Correct Answer
A. True

Explanation
Morphine is a basic drug, meaning it has a tendency to accept protons and become positively charged in an acidic environment. Since the stomach is an acidic environment, it is likely that morphine would exist mostly charged in the stomach. Therefore, the statement "Morphine would exist mostly charged in the acidic stomach" is true.

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13.

The cation NH₄⁺, when added to a solution, increases the pH of that solution.
- A.
  
  True
- B.
  
  False
Correct Answer
B. False

Explanation
The cation NH4+ is the ammonium ion, which is a weak acid. When added to a solution, it can act as an acid and donate a proton, thereby decreasing the pH of the solution. Therefore, the statement that the cation NH4+ increases the pH of a solution is false.

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14.

The anion Cl^-is the conjugate base of a strong acid, when added to a solution, it does not change the pH of that solution.
- A.
  
  True
- B.
  
  False
Correct Answer
A. True

Explanation
When an anion, such as Cl-, is the conjugate base of a strong acid, it means that it is formed when the strong acid donates a proton. Since strong acids completely dissociate in water, the resulting anion does not have any tendency to react with water and does not affect the concentration of H+ ions in the solution. Therefore, adding the anion to a solution will not change the pH of that solution, making the statement true.

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15.

If the pK_a is less than the pK_b, the solution will be acidic.
- A.
  
  True
- B.
  
  False
Correct Answer
A. True

Explanation
If the pKa is less than the pKb, it means that the acid dissociation constant is smaller than the base dissociation constant. This indicates that the acid is stronger than the base in the solution. In an acidic solution, the concentration of hydrogen ions (H+) is higher than the concentration of hydroxide ions (OH-). Therefore, the given statement is true.

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Current Version
Jun 19, 2024

Quiz Edited by
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Aug 17, 2011

Quiz Created by
Nscottatu

Cop 2015 Pharmaceutics Lecture 08/17/2011

The cation K+, when added to a solution, increases the pH of that solution.

Strong bases, such as NaOH, produce strong conjugate acids.

Which of the following would decrease the pH of a solution?

Which of the following is the correct Kb expression for the above reaction?

When water is part of an acid/base reaction, H2O is always included in the Ka and Kb expressions as either a reactant or a product.

All transition metals, when added to solution, will cause the solution to:

Fentanyl is used to induce anesthesia during hyperthermic treatment. During this treatment patients take longer to wake up because the Fentanyl is more active. Why is Fentanyl more active at higher temperatures? At 37C the pKa of Fentanyl is 8.22 At 42C the pKa of Fentanyl is 8.05

Fentanyl is used to induce anesthesia during hyperthermic treatment. During this treatment patients take longer to wake up because the Fentanyl is more active. During this treatment, Fentanyl will exist mostly in: At 37C the pKa of Fentanyl is 8.22 At 42C the pKa of Fentanyl is 8.05

Aspirin is an acidic drug that follows this basic equation: The pH of the ileum (the last portion of the small intestine) ranges from 7.0 - 8.0. Aspirin will be readily absorbed in the ileum.

For most drugs, the majority of absorption occurs in the duodenum.

Aniline is shown in this figure. The pKa of Aniline is 4.6. Calculate the pH of a 0.03M Aniline solution.

Morphine is a basic drug. Morphine would exist mostly charged in the acidic stomach.

The cation NH4+, when added to a solution, increases the pH of that solution.

The anion Cl- is the conjugate base of a strong acid, when added to a solution, it does not change the pH of that solution.

If the pKa is less than the pKb, the solution will be acidic.

The cation K⁺, when added to a solution, increases the pH of that solution.

Which of the following is the correct K_b expression for the above reaction?

When water is part of an acid/base reaction, H₂O is always included in the K_a and K_bexpressions as either a reactant or a product.

Fentanyl is used to induce anesthesia during hyperthermic treatment. During this treatment patients take longer to wake up because the Fentanyl is more active. Why is Fentanyl more active at higher temperatures? At 37C the pK_a of Fentanyl is 8.22 At 42C the pK_a of Fentanyl is 8.05

Fentanyl is used to induce anesthesia during hyperthermic treatment. During this treatment patients take longer to wake up because the Fentanyl is more active. During this treatment, Fentanyl will exist mostly in: At 37C the pK_a of Fentanyl is 8.22 At 42C the pK_a of Fentanyl is 8.05

Aniline is shown in this figure. The pK_a of Aniline is 4.6. Calculate the pH of a 0.03M Aniline solution.

The cation NH₄⁺, when added to a solution, increases the pH of that solution.

The anion Cl^-is the conjugate base of a strong acid, when added to a solution, it does not change the pH of that solution.

If the pK_a is less than the pK_b, the solution will be acidic.