Gene Therapy MCQ Exam! Quiz

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Gene therapy refers to a technique in which a person's DNA is treated and examined to prevent genetic disease. The DNA is suitably chosen to correct the effects of a disease-causing mutation. This technique was developed in 1972. Take this quiz to test your knowledge and learn about the process and impact of gene therapy.

Questions and Answers

1.

What Is Gene Therapy?
- A.
  
  Animals and Their Exact Clones in the world
- B.
  
  Treatments of Disorders and Diseases caused by inheritance
- C.
  
  Genetic Engineering
- D.
  
  Breeding of animals for an offspring
Correct Answer
B. Treatments of Disorders and Diseases caused by inheritance

Explanation
Gene therapy is a medical treatment that aims to treat disorders and diseases that are caused by inheritance. It involves introducing genetic material into a person's cells to correct or replace a faulty gene. This can help to prevent or alleviate the symptoms of genetic disorders and diseases. By targeting the root cause of these conditions, gene therapy offers the potential for long-term and potentially permanent treatments.

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2.

Who Invented Gene Therapy?
- A.
  
  William French Anderson
- B.
  
  Charles Darwin
- C.
  
  Gregor Mendel
- D.
  
  Michael Blaese
Correct Answer
A. William French Anderson

Explanation
William French Anderson is credited with inventing gene therapy. He is known as the "father of gene therapy" for his pioneering work in the field. In 1990, Anderson and his team successfully treated a patient with a genetic disorder using gene therapy, marking a significant milestone in medical history. His groundbreaking research and contributions have paved the way for the development and advancement of gene therapy as a potential treatment for various genetic diseases.

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3.

Is Gene Therapy an example of asexual or sexual reproduction and why?
- A.
  
  Sexual ; it needs a partner to happen
- B.
  
  Asexual ; it needs no partner to happen
- C.
  
  None of the above ; it has nothing to do with it
Correct Answer
C. None of the above ; it has nothing to do with it

Explanation
Gene therapy is not an example of either asexual or sexual reproduction because it does not involve the creation of new organisms or the transfer of genetic material between individuals. Instead, gene therapy involves the introduction or modification of genes within an individual's cells to treat or prevent disease. It is a medical technique rather than a reproductive process.

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4.

What is Gene Therapy said to have cured?
- A.
  
  Broken Limbs
- B.
  
  Aging in Humans & Animals
- C.
  
  Deadly Diseases
- D.
  
  None of the Above
Correct Answer
C. Deadly Diseases

Explanation
Gene therapy is a medical technique that involves altering or replacing faulty genes in order to treat or prevent diseases. It has shown promising results in curing deadly diseases such as cancer, cystic fibrosis, and certain genetic disorders. By correcting the underlying genetic defect, gene therapy aims to eliminate or reduce the symptoms of these life-threatening conditions. Therefore, the answer "Deadly Diseases" is the correct one as gene therapy is primarily used for the treatment of such illnesses.

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5.

Which gene is often inserted in an adenoviral vector to treat cancer by suicide gene therapy?
- A.
  
  HSV-TK
- B.
  
  IL-2
- C.
  
  GM-CSF
- D.
  
  VSV-G
Correct Answer
A. HSV-TK

Explanation
The thymidine kinase (TK) gene from the herpes simplex virus (HSV) has an enzymatic property that converts the drug ganciclovir into a toxic substance that can kill human dividing cells.

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6.

Which deficiency was attempted to be treated in the first patient who died during a gene therapy experiment in 1999?
- A.
  
  Chronic Granulomatus Disorder
- B.
  
  Ornithine transcarbamylase
- C.
  
  Duchenne muscular dystrophy
- D.
  
  Adenosine deaminase deficiency
Correct Answer
B. Ornithine transcarbamylase

Explanation
The first patient who died during a gene therapy experiment in 1999 was attempting to treat Ornithine transcarbamylase deficiency.

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7.

How are viruses referred to in which their envelope proteins have been replaced by other proteins, like VSV-G, to increase the tropism?
- A.
  
  Crippled viruses
- B.
  
  Replication deficient viruses
- C.
  
  Pseudotyped viruses
- D.
  
  Infectious viruses
Correct Answer
C. Pseudotyped viruses

Explanation
Pseudotyped viruses are referred to as viruses in which their envelope proteins have been replaced by other proteins, like VSV-G, to increase the tropism. This means that the original envelope proteins of the virus have been substituted with different proteins, allowing the virus to target and infect specific cell types that it normally couldn't. These pseudotyped viruses maintain their ability to infect cells, but with enhanced specificity due to the new envelope proteins.

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8.

A three-year-old boy was being treated for SCID using a modified retrovirus, but the boy developed a leukemia-like condition. What appeared to have caused this?
- A.
  
  The disorder is know to cause leukemia in most patients
- B.
  
  The retrovirus inserted near a proto-oncogene promoter
- C.
  
  The viral batch was contaminated with RCRs
- D.
  
  The retrovirus triggered the Human T-cell leukemia virus
Correct Answer
B. The retrovirus inserted near a proto-oncogene promoter

Explanation
The correct answer is that the retrovirus inserted near a proto-oncogene promoter. This means that the retrovirus inserted itself into the DNA near a region that controls the expression of an oncogene, which can lead to the development of cancer. This insertion likely caused the boy to develop a leukemia-like condition.

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9.

What is in general, not a risk factor in gene therapy using adenoviruses?
- A.
  
  Insertional mutagenesis
- B.
  
  Overexpression leading to an immune reaction
- C.
  
  Generation of replication competent adenoviruses
- D.
  
  Toxicity due to the administered viral dose
Correct Answer
A. Insertional mutagenesis

Explanation
Insertional mutagenesis is not a risk factor in gene therapy using adenoviruses. Insertional mutagenesis refers to the insertion of the therapeutic gene into the host genome, which can potentially disrupt normal gene function and lead to the development of cancer or other genetic abnormalities. However, adenoviruses are non-integrating vectors, meaning they do not integrate their DNA into the host genome. Therefore, the risk of insertional mutagenesis is low in adenovirus-based gene therapy.

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10.

What is not a product name for a replication-deficient adenoviral vector containing the p53 gene?
- A.
  
  Gendicine
- B.
  
  Advexin
- C.
  
  SCH58500
- D.
  
  Oncorine
Correct Answer
D. Oncorine

Explanation
Oncorine is not a product name for a replication-deficient adenoviral vector containing the p53 gene. Gendicine, Advexin, and SCH58500 are all examples of product names for such vectors, but Oncorine is not.

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Current Version
Aug 16, 2023

Quiz Edited by
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May 28, 2008

Quiz Created by
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Gene Therapy MCQ Exam! Quiz

What Is Gene Therapy?

Who Invented Gene Therapy?

Is Gene Therapy an example of asexual or sexual reproduction and why?

What is Gene Therapy said to have cured?

Which gene is often inserted in an adenoviral vector to treat cancer by suicide gene therapy?

Which deficiency was attempted to be treated in the first patient who died during a gene therapy experiment in 1999?

How are viruses referred to in which their envelope proteins have been replaced by other proteins, like VSV-G, to increase the tropism?

A three-year-old boy was being treated for SCID using a modified retrovirus, but the boy developed a leukemia-like condition. What appeared to have caused this?

What is in general, not a risk factor in gene therapy using adenoviruses?

What is not a product name for a replication-deficient adenoviral vector containing the p53 gene?