Immunology #8 - T Cell And Cellular Response

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| By Kmccor2008
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  • 1/7 Questions

    What cells suppress autoreactive T cells?

    • T regulatory cells
    • Dendritic cells
    • B cells
    • Cortical epithelial cells
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About This Quiz

This quiz titled 'Immunology #8 - T Cell and Cellular Response' assesses knowledge on T cell development and function, including markers, selection processes, and regulatory mechanisms. It is essential for students and professionals in biology and medicine.

Immunology Quizzes & Trivia

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  • 2. 

    Which of these molecules directly drives proliferation of T cells?

    • MHC

    • IFN

    • IL-2

    • IL-4

    Correct Answer
    A. IL-2
    Explanation
    IL-2 directly drives proliferation of T cells. IL-2 is a cytokine that is produced by activated T cells and plays a crucial role in regulating immune responses. It acts as a growth factor for T cells, promoting their proliferation and survival. IL-2 binds to IL-2 receptors on the surface of T cells, triggering a signaling cascade that leads to cell division and expansion of the T cell population. This cytokine is essential for the immune system's ability to mount an effective immune response against pathogens and tumors.

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  • 3. 

    Where does positive selection of T cells take place

    • Bone marrow

    • Dendritic Cells

    • Thymus cortex

    • Secondary lymphoid tissue

    Correct Answer
    A. Thymus cortex
    Explanation
    Positive selection of T cells takes place in the thymus cortex. This is where immature T cells undergo a selection process to ensure that only T cells with functional T cell receptors (TCRs) are allowed to mature and leave the thymus. The thymus cortex provides an environment for T cells to interact with self-antigens presented by specialized cells called thymic epithelial cells. T cells that recognize self-antigens with moderate affinity undergo positive selection, which leads to their maturation and differentiation into functional T cells capable of recognizing foreign antigens.

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  • 4. 

    The "double negative" contains

    • CD4 co-receptor

    • CD8 co-receptor

    • Inhibitory receptors

    • No co-receptors

    Correct Answer
    A. No co-receptors
    Explanation
    The "double negative" refers to a stage in T cell development where the cells do not express either CD4 or CD8 co-receptors. During this stage, T cells undergo further maturation and selection processes before they differentiate into CD4 or CD8 single-positive cells. Therefore, the correct answer is "No co-receptors" because double negative T cells do not have either CD4 or CD8 co-receptors.

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  • 5. 

    On which cells is B7 expressed?

    • T cells

    • Dendritic cells

    • Cortical Epithelial cells

    • Thymocytes

    Correct Answer
    A. Dendritic cells
    Explanation
    Dendritic cells are the cells on which B7 is expressed. B7 is a co-stimulatory molecule that plays a crucial role in the activation of T cells. Dendritic cells are antigen-presenting cells that capture, process, and present antigens to T cells, thus initiating an immune response. By expressing B7, dendritic cells provide the necessary co-stimulation to T cells, leading to their activation and subsequent immune response. Therefore, dendritic cells are essential for the initiation and regulation of immune responses.

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  • 6. 

    What happens when the co-stimulatory response is activated (i.e. B7 + CD28) without the binding of the MHC:peptide complex?

    • Tolerance

    • Autoreactive immune response

    • T cell activation

    • No effect on T cell

    Correct Answer
    A. No effect on T cell
    Explanation
    When the co-stimulatory response is activated without the binding of the MHC:peptide complex, it means that the T cell receptor (CD28) is not being engaged by the antigen-presenting cell. In this case, there will be no effect on the T cell because the co-stimulatory signal alone is not sufficient to activate the T cell. The binding of the MHC:peptide complex is necessary for T cell activation, so without it, the T cell will not be activated.

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  • 7. 

    What is the cell-surface marker of the stem cell progenitor from which T cells of both lineages originate?

    • CD2

    • CD34

    • CD28

    • CD5

    Correct Answer
    A. CD34
    Explanation
    CD34 is the correct answer because it is a cell-surface marker that is expressed on the stem cell progenitors from which T cells of both lineages originate. CD34 is commonly used as a marker to identify and isolate hematopoietic stem cells, including those that give rise to T cells. It is not expressed on mature T cells, but its expression is critical during early T cell development. CD2, CD28, and CD5 are also cell-surface markers associated with T cells, but they are not specifically expressed on the stem cell progenitors from which T cells originate.

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  • Mar 19, 2023
    Quiz Edited by
    ProProfs Editorial Team
  • Sep 30, 2012
    Quiz Created by
    Kmccor2008
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