1.
Which of the following domain is not found in the structure of nuclear receptors?
Correct Answer
D. F-domain
Explanation
The F-domain is not found in the structure of nuclear receptors. Nuclear receptors are transcription factors that regulate gene expression. They typically consist of several domains, including the DNA binding domain, hinge domain, and C-terminal domain. However, the F-domain is not a recognized domain in nuclear receptors.
2.
What are the three stages of cell signalling?
Correct Answer(s)
A. Reception
B. Transduction
D. Response
Explanation
Cell signaling is a complex process that involves communication between cells. The three stages of cell signaling are reception, transduction, and response. Reception occurs when a signaling molecule binds to a receptor protein on the cell surface, triggering a response. Transduction is the process by which the signal is converted into a cellular response through a series of molecular events. Finally, the response is the specific action or change that occurs in the cell as a result of the signaling pathway.
3.
Which of the following is an example of a second messenger?
Correct Answer
A. CAMP
Explanation
cAMP (cyclic adenosine monophosphate) is an example of a second messenger. Second messengers are molecules that transmit signals from the cell surface to the interior of the cell, amplifying the signal and initiating a cellular response. cAMP is commonly used in signal transduction pathways, where it is produced in response to extracellular signals and regulates various cellular processes such as metabolism, gene expression, and cell growth. It acts as a secondary messenger by activating protein kinase A (PKA) and other downstream effectors, ultimately leading to the desired cellular response.
4.
What are receptors?
Correct Answer
D. Proteins
Explanation
Receptors are proteins that are located on the surface of cells or inside cells. They play a crucial role in cell signaling by binding to specific molecules, such as hormones or neurotransmitters, and initiating a cellular response. Receptors are responsible for transmitting signals from the outside environment to the inside of the cell, allowing cells to respond and adapt to their surroundings.
5.
Which signaling molecules do simple nerve reflexes use?
Correct Answer
C. Neurotransmitters
Explanation
Simple nerve reflexes use neurotransmitters as signaling molecules. Neurotransmitters are chemicals that are released by neurons and are responsible for transmitting signals between nerve cells. They play a crucial role in the communication and coordination of the nervous system. When a nerve impulse reaches the end of a neuron, neurotransmitters are released into the synapse, or the small gap between neurons, where they bind to receptors on the next neuron, transmitting the signal and allowing for the relay of information. G proteins and nitric oxides are not typically involved in simple nerve reflexes.
6.
Which one is not a type of signaling molecule?
Correct Answer
D.
Adenylate cyclase
Explanation
Adenylate cyclase is not a type of signaling molecule. It is an enzyme that catalyzes the conversion of ATP to cyclic AMP (cAMP), which is a second messenger involved in intracellular signaling pathways. Thyroxin, testosterone, and insulin are all examples of signaling molecules that play important roles in various physiological processes.
7.
Which is not the extracellular signalling molcule?
Correct Answer
D. Serine kinases
Explanation
Serine kinases are not considered extracellular signaling molecules because they are intracellular enzymes that phosphorylate serine residues on target proteins. In contrast, hormones, neurotransmitters, and cytokines are all examples of extracellular signaling molecules that transmit signals between cells or tissues.
8.
Which is the highly conserved domain in the structure of nuclear receptors?
Correct Answer
A. DNA binding domain
Explanation
The highly conserved domain in the structure of nuclear receptors is the DNA binding domain. This domain is responsible for binding to specific DNA sequences known as hormone response elements (HREs) in the promoter regions of target genes. It allows the nuclear receptor to directly interact with DNA and regulate gene expression. The DNA binding domain is essential for the receptor's function as a transcription factor and is found in all nuclear receptors, making it highly conserved across different receptor subfamilies.
9.
Which is not the function of the G-protein coupled receptor?
Correct Answer
D. Doesn’t inhibit segregation of blood platelets
Explanation
The G-protein coupled receptor is involved in various cellular functions, including regulating muscle contraction, inhibiting the aggregation of blood platelets, and glycogen synthesis and breakdown. However, it does not have a function in inhibiting the segregation of blood platelets.
10.
Which is not the receptor of tyrosine kinase?
Correct Answer
B. Prolactin
Explanation
Prolactin is not a receptor of tyrosine kinase. Tyrosine kinase receptors are a type of cell surface receptor that have an enzyme activity called tyrosine kinase, which adds a phosphate group to tyrosine residues in proteins. PDGF, EGF-1, and FGF are all known to be receptors of tyrosine kinase. However, prolactin does not possess tyrosine kinase activity and therefore cannot function as a receptor for this signaling pathway.