Histones - High Yield Topic Series

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| By Kar

Kar, Assistant Professor (Biochemistry)

Karthikeyan Pethusamy is an assistant professor in the Department of Biochemistry at the All India Institute of Medical Sciences in New Delhi

Quizzes Created: 33 | Total Attempts: 47,616

Questions: 5 | Attempts: 109 | Updated: Oct 25, 2023

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Histones - High Yield Topic Series - Quiz

Study the High-Yield topics carefully.

Questions and Answers

1.

Anti histone antibodies are seen in
- A.
  
  Drug induced lupus
- B.
  
  SLE
- C.
  
  Primary biliary Cirrhosis
- D.
  
  Dermatomyositis
Correct Answer
A. Drug induced lupus

Explanation
Anti-histone antibodies are antibodies that target histones, which are proteins involved in packaging DNA in the nucleus of cells. These antibodies are commonly seen in drug-induced lupus, a condition where certain medications can cause lupus-like symptoms in individuals who are susceptible. Drug-induced lupus is different from systemic lupus erythematosus (SLE), which is an autoimmune disease where the body's immune system mistakenly attacks healthy tissues and organs. While anti-histone antibodies can also be found in SLE, their presence is more strongly associated with drug-induced lupus. Therefore, the correct answer is drug-induced lupus.

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2.

Histone acetylation leads to
- A.
  
  Euchromatin
- B.
  
  Heterochromatin
- C.
  
  Both of the above
- D.
  
  None of the above
Correct Answer
A. Euchromatin

Explanation
Histone acetylation refers to the process of adding acetyl groups to histone proteins, which are involved in DNA packaging. This modification loosens the structure of chromatin, allowing for easier access to DNA and promoting gene expression. Euchromatin is a less condensed form of chromatin that is actively transcribed, while heterochromatin is a highly condensed form that is transcriptionally inactive. Therefore, histone acetylation leads to euchromatin formation, making the correct answer "Euchromatin".

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3.

Poly A tail is usually present in 3' end of all pre-mRNA. But it is not present in the pre-mRNA of histone.
- A.
  
  True
- B.
  
  False
Correct Answer
A. True

Explanation
The poly A tail is a sequence of adenine nucleotides that is usually added to the 3' end of pre-mRNA molecules during RNA processing. However, in the case of histone pre-mRNA, this poly A tail is not present. This is because histone genes have a different mechanism of mRNA processing that involves cleavage and polyadenylation at a specific site within the coding region, rather than at the 3' end. Therefore, the statement that the poly A tail is not present in the pre-mRNA of histone is true.

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4.

Instead of poly A tail, which structure is present in the 3' end of the pre-mRNA of histone ?
- A.
  
  Stem loop
- B.
  
  Zinc finger
- C.
  
  Leucine zipper
- D.
  
  None of the above
Correct Answer
A. Stem loop

Explanation
In the 3' end of the pre-mRNA of histone, a structure called a stem loop is present instead of a poly A tail. A stem loop is a secondary structure formed when a sequence of nucleotides in the mRNA folds back on itself, creating a stem and a loop. This structure is important for the stability and regulation of the mRNA molecule.

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5.

Select the wrong statement ?
- A.
  
  Histone methylation is in general associated with transcriptional repression
- B.
  
  Histone acetylation tends to destabilize chromatin structure
- C.
  
  Histone is rich in basic amino acids.
- D.
  
  H1 is a component of Histone octamer.
Correct Answer
D. H1 is a component of Histone octamer.

Explanation
H1 histone is a linker.

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Current Version
Oct 25, 2023

Quiz Edited by
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May 07, 2012

Quiz Created by
Kar

Histones - High Yield Topic Series

Anti histone antibodies are seen in

Histone acetylation leads to

Poly A tail is usually present in 3' end of all pre-mRNA. But it is not present in the pre-mRNA of histone.

Instead of poly A tail, which structure is present in the 3' end of the pre-mRNA of histone ?

Select the wrong statement ?