1.
A pharmaceutical company has developed a new compound that is well tolerated by the body and inhibits the sterol ergo sterol synthesis. Screening of anti-infectious agent activity should be directed toward
Correct Answer
C. Fungi
Explanation
Fungi have ergo sterol as their dominant membrane sterol. Mycoplasmas are the only prokaryotes with sterols in their cytoplasmic membrane, but they do not synthesize their own sterols.
2.
50S ribosomal subunits are found in
Correct Answer
A. Bacteria
Explanation
Bacteria have70S ribosomes composed of 30S and 50S subunits. Fungi and protozoa have 80S ribosomes, and prions and viruses do not have ribosomes.
3.
The normal flora of the large intestine consists mainly of
Correct Answer
A. Bacteria
Explanation
Bacteria form the majority of the normal flora of the large intestine. Other types of human infectious agents are not usually present except in time of disease.
4.
The minimal concentration of alcohol necessary to kill bacteria and enveloped viruses is
Correct Answer
E. 70%
Explanation
An alcohol concentration of 70% to 95% is necessary to kill bacteria
5.
Human obligate intracellular pathogens that depend on the host cell for ATP production are
Correct Answer
D. Rickettsia species
Explanation
Chlamydia and rickettsia are obligate intracellular pathogens because they depend on the host cell
to provide them with ATP.
6.
Dimorphism is a characteristic of
Correct Answer
B. Fungi
Explanation
Certain species of pathogenic fungi are dimorphic (i.e., existing as yeast or mold forms depending
on their environment).
7.
A new infectious agent has been isolated from deer ticks. It lacks a cell wall but has 70S ribosomes.
This agent is most likely a
Correct Answer
C. Mycoplasma species
Explanation
The correct answer is Mycoplasma species. Mycoplasma species are unique bacteria that lack a cell wall, making them resistant to antibiotics that target cell wall synthesis. They also have 70S ribosomes, which are characteristic of bacteria. Chlamydia species and Rickettsia species are also bacteria, but they have cell walls. Viruses are not considered bacteria and do not possess ribosomes.
8.
Chapter 2 BACTERIA
A bacterial toxin with super antigen activity is produced by
Correct Answer
D. StapHylococcus aureus
Explanation
Staphylococcus aureus produces an enterotoxin and TSST-1 toxins with super-antigen activity.
Streptococcus pyogenes also produces toxins with this activity.
9.
Sugar transport into bacteria is frequently facilitated by
Correct Answer
E. pHospHo transferases
Explanation
The transport of sugar into a bacterium frequently involves the transfer of a phosphate group to the s
ugar molecule.
10.
Thayer-Martin and Martin-Lewis media are used to isolate and identify
E. coli
Correct Answer
C. Neisseria
Explanation
These media are variants of chocolate agar and contain antibiotics that inhibit many normal respiratory
and genital bacteria but allow the growth of Neisseria species.
11.
B-lactamases confer antibiotic resistance by
Correct Answer
E. Modifying antibiotic structure
Explanation
B-lactamases cleave the b-lactam ring structure that is important for the antibacterial activity of penicillins,
cephalosporins, monobactams, and carbapenems.
12.
Polymers of N-acetyl glucosamine and N-acetyl muramic acid are found in which of the following
structures?
Correct Answer
B. Cell wall
Explanation
N-acetyl glucosamine and N-acetyl muramic acid are polymerized to form the peptidoglycan backbone of the cell wall.
13.
A phage that is not inactivated by proteases is called a
Correct Answer
A. PropHage
Explanation
A prophage is the intracellular DNA of a phage and is therefore resistant to protease degradation.
14.
Bacteria that synthesize organic compounds from inorganic compounds are
Correct Answer
E. AutotropHs
Explanation
Autotrophic bacteria do not require organic compounds for growth because they synthesize them
from inorganic precursors.
15.
A bacterial structure involved in adherence is
Correct Answer
C. Ordinary pili
Explanation
Ordinary pili, adhesins, and the glycocalyx are three bacterial structures that are involved in adherence.
16.
Aminoglycoside antibiotics are
Correct Answer
E. Require bacterial growth for the effect
Explanation
Bacteria must be actively replicating and synthesizing protein for these compounds, which bind
to the 30S ribosomal subunit to have their bactericidal effect.
17.
A-B subunit structure as it relates to bacterial pathogenesis refers to the structure of
Correct Answer
A. Bacterial exotoxins
Explanation
Many bacterial exotoxins have an A-B subunit structure in which the B subunit is involved in binding
and the A subunit possesses biological activity inside the affected cell.
18.
Which of the following displays the Pasteur effect?
Correct Answer
D. Facultative anaerobes
Explanation
Facultative anaerobes shift from a fermentative to a respiratory metabolism in the presence of
air because the energy needs of the cell are met by consuming less glucose (Pasteur Effect) under respiratory metabolism.
19.
Which of the following toxins acts on synaptosomes?
Correct Answer
B. Clostridium tetani exotoxin
Explanation
Clostridium tetani Exotoxin acts on synaptosomes, thereby causing hyper-reflexia of skeletal muscles.
20.
Superoxide dismutase-containing bacteria
Correct Answer
D. Produce hydrogen peroxide from hydrogen ion and the superoxide free radical (O2-)
Explanation
Superoxide dismutase is found in aerobic and facultative anaerobic bacteria. It protects them from
the toxic free radical (O2-) by combining it with a hydrogen ion to form hydrogen peroxide, which is
subsequently degraded by peroxidase.
21.
Lysogenic phage conversion involves
Correct Answer
B. A change in bacterial pHenotype due to the presence of a propHage
Explanation
Lysogenic phage conversion refers to the process in which a bacterial phenotype changes as a result of the presence of a prophage. A prophage is a viral genome that has integrated into the bacterial chromosome and remains dormant until it is activated. When the prophage is activated, it can cause changes in the bacterial phenotype, such as the production of toxins or other virulence factors. This change in phenotype is the result of the expression of genes carried by the prophage, which can alter the behavior or characteristics of the bacterial host.
22.
Bacteria capable of growth in a high salt concentration are best isolated in which of the following media?
Correct Answer
D. Selective growth media
Explanation
A selective growth medium that contains a high salt concentration would permit bacterial growth.
23.
Bacteria lacking superoxide dismutase are
Correct Answer
B. Obligate anaerobes
Explanation
Superoxide dismutase, which is present in aerobes and facultative anaerobe organisms, protects them
from the toxic O2- radical. This enzyme is not present in obligate anaerobes.
24.
The regulation of enzyme activity in bacterial cells can
Correct Answer
A. Be coupled to the binding of effector molecules
Explanation
The biochemical activity of an enzyme may be regulated by binding of effect or molecules or by
biosynthetic pathway end-product feedback inhibition. Enzyme synthesis may be controlled by inducers,
attenuation sequences, or catabolite activator protein.
25.
The plasma membrane
Correct Answer
D. Contains the enzymes involved in bacterial oxidative pHospHorylation
Explanation
The plasma membrane contains the enzymes involved in oxidative phosphorylation
26.
Bacterial antibiotic resistance is frequently conveyed by
Correct Answer
B. An R-factor plasmid
Explanation
R-factor (resistance) plasmids contain genes for proteins that degrade antibiotics or alter antibiotic
transport, thus conferring antibiotic resistance. They also carry transfer genes, which facilitate their
intercellular transfer to other genomes.
27.
The expression of the lac operon
Correct Answer
A. Must be initiated by the binding of an inducer protein
Explanation
The transcription of the lac operon is under negative control. Initiation depends on the binding of
allolactose to a repressor protein. This reaction prevents the repressor from binding to the operator
region, thus allowing RNA polymerase to bind and transcription to proceed.
28.
Bacteriophage containing host-cell DNA is involved in which of the following processes?
Correct Answer
C. Transduction
Explanation
Bacteriophages containing portions of host-cell DNA can introduce this genetic material into new host cells via the process of transduction.
29.
The exchange of allelic forms of genes is involved in which of the following processes?
Correct Answer
E. Recombination
Explanation
DNA or genetic recombination is the general term used to describe the exchange of allelic forms
of genes in bacteria or eukaryotic cells.
30.
Which of the following processes creates high-frequency recombination donors?
Correct Answer
E. Recombination
Explanation
High-frequency recombination donors, which result from the integration of a fertility (F) factor in to
chromosomal DNA, are created by recombination.