Pg Blazer - Online Test Series 10 - Pathology
MCQ's in pathology. For more practice tests, go to PG Blazer Online Test Series
- 1.
Non specific esterase is positive in all the categories of AML except
- A.
M3
- B.
M4
- C.
M5
- D.
M6
Correct Answer
D. M6Explanation
Non specific esterase is characteristically seen in M4 and M5. It is also seen in some cases of M3 and M7.Rate this question:
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- 2.
A diabetic patient is undergoing dialysis. Aspiration done around the knee joint would show,
- A.
Aβ2 microglobulin
- B.
AA
- C.
AL
- D.
Lactoferrin
Correct Answer
A. Aβ2 microglobulinExplanation
Patients undergoing long term dialysis is prone to development of amyloidosis. The type of amyloid protein that gets deposited in this condition is Aβ2 microglobulin.Rate this question:
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- 3.
What is the best method for confirming amyloidosis :
- A.
Colonoscopy
- B.
Sigmoidoscopy
- C.
Rectal biopsy
- D.
Tongue biopsy
Correct Answer
C. Rectal biopsyExplanation
Sensitivity for diagnosis of amyloidosis in various biopsy sites:
Rectal / gingival - 80%
Abdominal fat aspirate - 70-80%
Bone marrow - 50%Rate this question:
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- 4.
Michaelis Gutmann bodies are seen in
- A.
Xanthogranulomatous pyelonephritis
- B.
Malakoplakia
- C.
Nail patella syndrome
Correct Answer
B. MalakoplakiaExplanation
Michaelis-Gutmann bodies are concentrically layered basophilic inclusions found in the urinary tract. The size ranges from 2 to 10 μm in diameter. They are believed to be remnants of phagosomes mineralized by iron and calcium deposits. Histologic identification of M-G bodies are pathognomonic of malakoplakia.Rate this question:
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- 5.
True about Apoptosis are all except :
- A.
Inflammation is present
- B.
Chromosomal breakage
- C.
Clumping of chromatin
- D.
Cell shrinkage
Correct Answer
A. Inflammation is presentExplanation
Inflammation is absent in apoptosis. It is seen only in necrosis.Rate this question:
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- 6.
Finding on histopathological examination in liver in case of malaria is :
- A.
Microabscess formation
- B.
Kupffer‘s cell hyperplasia with macrophage infiltration around periportal area laden with pigments.
- C.
Non caseating granuloma
- D.
Non specific finding of neutrophilic infiltration
Correct Answer
B. Kupffer‘s cell hyperplasia with macropHage infiltration around periportal area laden with pigments.Explanation
The correct answer is "Kupffer's cell hyperplasia with macrophage infiltration around periportal area laden with pigments." In cases of malaria, the liver can show an increase in Kupffer cells, which are specialized macrophages responsible for clearing foreign substances from the blood. These Kupffer cells can become hyperplastic and infiltrate the periportal area, which is the area around the portal vein. Additionally, these cells can be laden with pigments, which may be a result of the breakdown of red blood cells during the infection. This finding is specific to malaria and helps in the diagnosis of the disease.Rate this question:
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- 7.
Least affected in Graft – Versus host reaction:
- A.
Skin
- B.
G.I.T
- C.
Liver
- D.
Lung
Correct Answer
D. LungExplanation
Any organ can be affected in GVH reaction. The most important is the involvement of immune system, skin, liver and intestines.Rate this question:
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- 8.
Brain natriuretic peptide is degraded by
- A.
Neutral endopeptidase
- B.
Elastase
- C.
Collagenase
- D.
Omapatrilat
Correct Answer
A. Neutral endopeptidaseExplanation
BNP is degraded by neutral endopeptidase. Omapatrilat inhibits neutral endopeptidase. Hence it is useful in treatment of heart failure.Rate this question:
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- 9.
All are B cell marker except :
- A.
CD-19
- B.
CD-21
- C.
CD-15
- D.
CD-22
Correct Answer
C. CD-15Explanation
CD-15 is seen in neutrophils, eosinophils and monocytes.
B cell markers are : CD 19, CD 20, CD 21, CD 22Rate this question:
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- 10.
Most common gene defect in Idiopathic Steroid Resistant Nephrotic Syndrome
- A.
ACE
- B.
NPHS 2
- C.
HOX ll
- D.
PAX
Correct Answer
B. NpHS 2Explanation
NPHS 2 gene coding for the protein podocin (located in the slit diaphragm) is mutated in steroid resistant nephrotic syndrome.Rate this question:
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Current Version
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Mar 19, 2023Quiz Edited by
ProProfs Editorial Team -
Jun 14, 2011Quiz Created by
Pgblazer
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